RTCR_ECOLI
ID RTCR_ECOLI Reviewed; 532 AA.
AC P38035; Q2M786;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Transcriptional regulatory protein RtcR;
GN Name=rtcR; Synonyms=yhgB; OrderedLocusNames=b3422, JW3385;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 343-532.
RC STRAIN=K12;
RX PubMed=3045764; DOI=10.1093/nar/16.15.7732;
RA Choi Y.-L., Kawase S., Nishida T., Sakai H., Komano T., Kawamukai M.,
RA Utsumi R., Kohara Y., Akiyama K.;
RT "Nucleotide sequence of the glpR gene encoding the repressor for the
RT glycerol-3-phosphate regulon of Escherichia coli K12.";
RL Nucleic Acids Res. 16:7732-7732(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 346-532.
RC STRAIN=K12;
RA Ye S., Larson T.J.;
RL Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION.
RX PubMed=7984428; DOI=10.1093/nar/22.22.4756;
RA Borodovsky M., Rudd K.E., Koonin E.V.;
RT "Intrinsic and extrinsic approaches for detecting genes in a bacterial
RT genome.";
RL Nucleic Acids Res. 22:4756-4767(1994).
RN [6]
RP IDENTIFICATION.
RX PubMed=7920643; DOI=10.1038/ng0694-205;
RA Robison K., Gilbert W., Church G.M.;
RT "Large scale bacterial gene discovery by similarity search.";
RL Nat. Genet. 7:205-214(1994).
RN [7]
RP FUNCTION.
RX PubMed=9738023; DOI=10.1074/jbc.273.39.25516;
RA Genschik P., Drabikowski K., Filipowicz W.;
RT "Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase
RT and its sigma54-regulated operon.";
RL J. Biol. Chem. 273:25516-25526(1998).
CC -!- FUNCTION: Transcriptional repressor of the rtcAB genes. Interacts with
CC sigma-54. {ECO:0000269|PubMed:9738023}.
CC -!- SEQUENCE CAUTION:
CC Sequence=X07520; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=X07520; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U18997; AAA58220.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76447.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77870.1; -; Genomic_DNA.
DR EMBL; X07520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; M96795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; A65138; A65138.
DR RefSeq; NP_417880.1; NC_000913.3.
DR RefSeq; WP_001232948.1; NZ_LN832404.1.
DR AlphaFoldDB; P38035; -.
DR SMR; P38035; -.
DR BioGRID; 4261191; 13.
DR DIP; DIP-10812N; -.
DR IntAct; P38035; 5.
DR STRING; 511145.b3422; -.
DR PaxDb; P38035; -.
DR PRIDE; P38035; -.
DR EnsemblBacteria; AAC76447; AAC76447; b3422.
DR EnsemblBacteria; BAE77870; BAE77870; BAE77870.
DR GeneID; 947928; -.
DR KEGG; ecj:JW3385; -.
DR KEGG; eco:b3422; -.
DR PATRIC; fig|1411691.4.peg.3307; -.
DR EchoBASE; EB2259; -.
DR eggNOG; COG4650; Bacteria.
DR HOGENOM; CLU_039506_0_0_6; -.
DR InParanoid; P38035; -.
DR OMA; CWFLLTE; -.
DR PhylomeDB; P38035; -.
DR BioCyc; EcoCyc:EG12356-MON; -.
DR PRO; PR:P38035; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009715; RtcR.
DR InterPro; IPR017183; Sigma54_dep_tscrpt_act_RtcR.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR PANTHER; PTHR32071:SF14; PTHR32071:SF14; 1.
DR Pfam; PF06956; RtcR; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR PIRSF; PIRSF037354; Txn_actvtr_RtcR; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 4: Predicted;
KW ATP-binding; DNA-binding; Nucleotide-binding; Reference proteome;
KW Repressor; Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1..532
FT /note="Transcriptional regulatory protein RtcR"
FT /id="PRO_0000081335"
FT DOMAIN 186..424
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT DNA_BIND 485..504
FT /note="H-T-H motif"
FT /evidence="ECO:0000255"
FT BINDING 215..222
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT BINDING 281..290
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
SQ SEQUENCE 532 AA; 60299 MW; 86351442491E04DD CRC64;
MRKTVAFGFV GTVLDYAGRG SQRWSKWRPT LCLCQQESLV IDRLELLHDA RSRSLFETLK
RDIASVSPET EVVSVEIELH NPWDFEEVYA CLHDFARGYE FQPEKEDYLI HITTGTHVAQ
ICWFLLAEAR YLPARLIQSS PPRKKEQPRG PGEVTIIDLD LSRYNAIASR FAEERQQTLD
FLKSGIATRN PHFNRMIEQI EKVAIKSRAP ILLNGPTGAG KSFLARRILE LKQARHQFSG
AFVEVNCATL RGDTAMSTLF GHVKGAFTGA RESREGLLRS ANGGMLFLDE IGELGADEQA
MLLKAIEEKT FYPFGSDRQV SSDFQLIAGT VRDLRQLVAE GKFREDLYAR INLWTFTLPG
LRQRQEDIEP NLDYEVERHA SLTGDSVRFN TEARRAWLAF ATSPQATWRG NFRELSASVT
RMATFATSGR ITLDVVEDEI NRLRYNWQES RPSALTALLG AEAENIDLFD RMQLEHVIAI
CRQAKSLSAA GRQLFDVSRQ GKASVNDADR LRKYLARFGL TWEAVQDQHS SS
