RTE1_ARATH
ID RTE1_ARATH Reviewed; 250 AA.
AC F4ITL6; O80989; Q8GZ39;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Protein REVERSION-TO-ETHYLENE SENSITIVITY1;
GN Name=RTE1; OrderedLocusNames=At2g26070; ORFNames=T19L18.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF CYS-161, AND INDUCTION BY
RP ETHYLENE.
RX PubMed=16682642; DOI=10.1073/pnas.0602239103;
RA Resnick J.S., Wen C.K., Shockey J.A., Chang C.;
RT "REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates
RT ethylene receptor function in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7917-7922(2006).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=17644624; DOI=10.1104/pp.107.104299;
RA Zhou X., Liu Q., Xie F., Wen C.K.;
RT "RTE1 is a Golgi-associated and ETR1-dependent negative regulator of
RT ethylene responses.";
RL Plant Physiol. 145:75-86(2007).
RN [7]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION BY ETHYLENE.
RX PubMed=17999643; DOI=10.1111/j.1365-313x.2007.03339.x;
RA Dong C.H., Rivarola M., Resnick J.S., Maggin B.D., Chang C.;
RT "Subcellular co-localization of Arabidopsis RTE1 and ETR1 supports a
RT regulatory role for RTE1 in ETR1 ethylene signaling.";
RL Plant J. 53:275-286(2008).
RN [8]
RP FUNCTION.
RX PubMed=18643990; DOI=10.1111/j.1365-313x.2008.03615.x;
RA Resnick J.S., Rivarola M., Chang C.;
RT "Involvement of RTE1 in conformational changes promoting ETR1 ethylene
RT receptor signaling in Arabidopsis.";
RL Plant J. 56:423-431(2008).
RN [9]
RP FUNCTION.
RX PubMed=19369589; DOI=10.1104/pp.109.138461;
RA Rivarola M., McClellan C.A., Resnick J.S., Chang C.;
RT "ETR1-specific mutations distinguish ETR1 from other Arabidopsis ethylene
RT receptors as revealed by genetic interaction with RTE1.";
RL Plant Physiol. 150:547-551(2009).
RN [10]
RP INTERACTION WITH ETR1, AND MUTAGENESIS OF CYS-161.
RX PubMed=20952388; DOI=10.1074/jbc.m110.146605;
RA Dong C.H., Jang M., Scharein B., Malach A., Rivarola M., Liesch J.,
RA Groth G., Hwang I., Chang C.;
RT "Molecular association of the Arabidopsis ETR1 ethylene receptor and a
RT regulator of ethylene signaling, RTE1.";
RL J. Biol. Chem. 285:40706-40713(2010).
CC -!- FUNCTION: Acts at an early step in the ethylene signaling pathway.
CC Positively regulates ETR1, leading to the negative regulation of
CC ethylene responses. {ECO:0000269|PubMed:16682642,
CC ECO:0000269|PubMed:18643990, ECO:0000269|PubMed:19369589}.
CC -!- SUBUNIT: Interacts with ETR1 through a region corresponding to its
CC ethylene-binding domain. {ECO:0000269|PubMed:20952388}.
CC -!- INTERACTION:
CC F4ITL6; P49333: ETR1; NbExp=5; IntAct=EBI-2437263, EBI-1606682;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:17644624, ECO:0000269|PubMed:17999643}; Multi-pass
CC membrane protein {ECO:0000255}. Golgi apparatus membrane
CC {ECO:0000269|PubMed:17644624, ECO:0000269|PubMed:17999643}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in 1-4-day-old seedlings in the
CC apical hook, cotyledons, root vascular tissue, root tip and root hairs,
CC with little or no expression in the hypocotyl. In light-grown
CC seedlings, expression could also be seen in the apex and young leaves,
CC and disappeared from the cotyledons by 10 days. In mature plants,
CC expressed in floral buds, the style of mature flowers, stems and the
CC rachis. {ECO:0000269|PubMed:17999643}.
CC -!- INDUCTION: By ethylene. {ECO:0000269|PubMed:16682642,
CC ECO:0000269|PubMed:17999643}.
CC -!- DISRUPTION PHENOTYPE: Enhanced ethylene sensitivity.
CC {ECO:0000269|PubMed:16682642}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC31229.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAO39957.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC Sequence=BAC41901.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC004747; AAC31229.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07792.1; -; Genomic_DNA.
DR EMBL; AK117225; BAC41901.1; ALT_SEQ; mRNA.
DR EMBL; BT003729; AAO39957.1; ALT_SEQ; mRNA.
DR PIR; T02616; T02616.
DR RefSeq; NP_180177.2; NM_128166.4.
DR AlphaFoldDB; F4ITL6; -.
DR BioGRID; 2500; 6.
DR IntAct; F4ITL6; 2.
DR STRING; 3702.AT2G26070.1; -.
DR PaxDb; F4ITL6; -.
DR PRIDE; F4ITL6; -.
DR ProteomicsDB; 226634; -.
DR EnsemblPlants; AT2G26070.1; AT2G26070.1; AT2G26070.
DR GeneID; 817148; -.
DR Gramene; AT2G26070.1; AT2G26070.1; AT2G26070.
DR KEGG; ath:AT2G26070; -.
DR Araport; AT2G26070; -.
DR TAIR; locus:2057366; AT2G26070.
DR eggNOG; KOG3150; Eukaryota.
DR HOGENOM; CLU_075672_0_0_1; -.
DR InParanoid; F4ITL6; -.
DR PRO; PR:F4ITL6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4ITL6; baseline and differential.
DR Genevisible; F4ITL6; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0010105; P:negative regulation of ethylene-activated signaling pathway; IMP:TAIR.
DR GO; GO:0010104; P:regulation of ethylene-activated signaling pathway; IBA:GO_Central.
DR GO; GO:0009723; P:response to ethylene; IEP:TAIR.
DR InterPro; IPR008496; TMEM222/RTE1.
DR PANTHER; PTHR20921; PTHR20921; 1.
DR Pfam; PF05608; DUF778; 2.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..250
FT /note="Protein REVERSION-TO-ETHYLENE SENSITIVITY1"
FT /id="PRO_0000414064"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MUTAGEN 161
FT /note="C->Y: Enhances ethylene sensitivity. Reduces ETR1
FT binding efficiency."
FT /evidence="ECO:0000269|PubMed:16682642,
FT ECO:0000269|PubMed:20952388"
SQ SEQUENCE 250 AA; 27932 MW; 33A5E8AE4AF0EF93 CRC64;
MSRGRGVPMM DLKRSYDVED RVVSVSIPSI IEADEADLWP LPEIDTKKSK FPCCIVWTPL
PVVSWLAPFI GHIGLCREDG VILDFAGSNF INVDDFAFGP PARYLQLDRT KCCLPPNMGG
HTCKYGFKHT DFGTARTWDN ALSSSTRSFE HKTYNIFTCN CHSFVANCLN RLCYGGSMEW
NMVNVAILLM IKGKWINGSS VVRSFLPCAV VTSLGVVLVG WPFLIGLSSF SLLLFAWFII
ATYCFKNIIT
