ID   RTEL1_AEDAE             Reviewed;        1010 AA.
AC   Q16X92;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Regulator of telomere elongation helicase 1 homolog {ECO:0000255|HAMAP-Rule:MF_03065};
DE            EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_03065};
GN   ORFNames=AAEL008960;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: ATP-dependent DNA helicase implicated in DNA repair and the
CC       maintenance of genomic stability. Acts as an anti-recombinase to
CC       counteract toxic recombination and limit crossover during meiosis.
CC       Regulates meiotic recombination and crossover homeostasis by physically
CC       dissociating strand invasion events and thereby promotes noncrossover
CC       repair by meiotic synthesis dependent strand annealing (SDSA) as well
CC       as disassembly of D loop recombination intermediates.
CC       {ECO:0000255|HAMAP-Rule:MF_03065}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_03065};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065}.
CC   -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03065}.
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DR   EMBL; CH477545; EAT39227.1; -; Genomic_DNA.
DR   RefSeq; XP_001653621.1; XM_001653571.1.
DR   AlphaFoldDB; Q16X92; -.
DR   SMR; Q16X92; -.
DR   STRING; 7159.AAEL008960-PA; -.
DR   PRIDE; Q16X92; -.
DR   GeneID; 5571306; -.
DR   KEGG; aag:5571306; -.
DR   VEuPathDB; VectorBase:AAEL008960; -.
DR   eggNOG; KOG1132; Eukaryota.
DR   HOGENOM; CLU_006515_4_0_1; -.
DR   InParanoid; Q16X92; -.
DR   OMA; GNCATIV; -.
DR   OrthoDB; 186062at2759; -.
DR   PhylomeDB; Q16X92; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_03065; RTEL1; 1.
DR   InterPro; IPR006555; ATP-dep_Helicase_C.
DR   InterPro; IPR010614; DEAD_2.
DR   InterPro; IPR045028; DinG/Rad3-like.
DR   InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR   InterPro; IPR006554; Helicase-like_DEXD_c2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013020; Rad3/Chl1-like.
DR   InterPro; IPR030845; RTEL1.
DR   PANTHER; PTHR11472; PTHR11472; 1.
DR   Pfam; PF06733; DEAD_2; 1.
DR   Pfam; PF13307; Helicase_C_2; 1.
DR   SMART; SM00488; DEXDc2; 1.
DR   SMART; SM00491; HELICc2; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00604; rad3; 1.
DR   PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase;
KW   Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..1010
FT                   /note="Regulator of telomere elongation helicase 1 homolog"
FT                   /id="PRO_0000370617"
FT   DOMAIN          7..333
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT   REGION          912..931
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           263..266
FT                   /note="DEAH box"
FT   COMPBIAS        916..931
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         42..49
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT   BINDING         157
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT   BINDING         175
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT   BINDING         184
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT   BINDING         220
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
SQ   SEQUENCE   1010 AA;  113780 MW;  83277CCB759F0CA1 CRC64;
     MPEYQINGIT VNFPFEPYQV QRDYMSRVIE CLQNSTNGVL ESPTGTGKTL SLLCSSLAWV
     LHKKAQVQAN MRTNITDLKE FEMVQRKKLG GDGGSGMEEL LDKLHDGCGP EGAKWGVPKI
     VYASRTHSQL TQVMQEMKNT SYSFMKGVIL GSRDQLCIHP EVSKEEGNST KTNLCKAKVQ
     SRTCSFYSRV ESCKERPEVV SNVIMDIEDL VKVGTKVRAC PFFLSKELIE SADILFMPYN
     YLLDPKARKA NNLEISNTII ILDEAHNVEK MCEESASMQI RSTDIALCID DVTSIMKVMD
     HSVAIPEDDE TKKDFTIDDL ALLKEMLLQL EKTVDSIPVM FSQGGNTFPG TYIFEIFEKA
     NIKEGNYHII AQLLENIIQY IATITEKNNF VRRGGGLQIL AEALSIIFAG SGPEYRASID
     KCYKVHIEIE EQKKTRGNVK QADGWTATKQ LVPSVKANAK VVSFWCFNPG FGMRQLLGRN
     ARSIILTSGT LAPLKPLISE LDIPIAVRLE NPHIIDGSQV CVKIVGQGPD KESLNSSYGN
     RDNPKYISSL GRTILSFCPI IPGGLLVFFP SYPLLNKCQE AWQETGIWAQ ISRTKPIFVE
     PRGKDQFLNT MSEYYQKIND PDGKGAVFMA VCRGKVSEGL DFADMNGRAV IITGLPFPPL
     KDARVILKKK YLQEVRTREN EIISGDEWYS LEAARAVNQA IGRVIRHKND YGAILLCDNR
     FHNHRQKSQL SSWIQKHLNT NQHQNFGPII GELSRFFRNA EKILPQSKLS RNIVTLVQEP
     TPLIECNIPG ALIVNRDTKR KLDDIRNNFV QIENSNQVTS TFRISDYEQA PSQSASNEPK
     NFLSRLNTQV HSIDFNDMTT YSMPSSSQGA LVGIHKRERS TGSDNSIFSQ TQTATQKKRK
     VVLIPQQVIN LTSDDEDPGR TGDDPTRQAP EDRVELIKVI KTSIPLAKYQ AFLSTLTNYN
     KDRNFDRLME GLLVAFDRPE LYYLLRAMRR FVKGDHEARF DAKIKEVCGR