RTEL1_DROAN
ID RTEL1_DROAN Reviewed; 994 AA.
AC B3MSG8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Regulator of telomere elongation helicase 1 homolog {ECO:0000255|HAMAP-Rule:MF_03065};
DE EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_03065};
GN ORFNames=GF20802;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: ATP-dependent DNA helicase implicated in DNA repair and the
CC maintenance of genomic stability. Acts as an anti-recombinase to
CC counteract toxic recombination and limit crossover during meiosis.
CC Regulates meiotic recombination and crossover homeostasis by physically
CC dissociating strand invasion events and thereby promotes noncrossover
CC repair by meiotic synthesis dependent strand annealing (SDSA) as well
CC as disassembly of D loop recombination intermediates.
CC {ECO:0000255|HAMAP-Rule:MF_03065}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_03065};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03065}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH902622; EDV34723.1; -; Genomic_DNA.
DR RefSeq; XP_001964274.1; XM_001964238.2.
DR AlphaFoldDB; B3MSG8; -.
DR SMR; B3MSG8; -.
DR STRING; 7217.FBpp0123994; -.
DR EnsemblMetazoa; FBtr0125502; FBpp0123994; FBgn0097808.
DR GeneID; 6503494; -.
DR KEGG; dan:6503494; -.
DR eggNOG; KOG1132; Eukaryota.
DR HOGENOM; CLU_006515_4_0_1; -.
DR InParanoid; B3MSG8; -.
DR OMA; GNCATIV; -.
DR OrthoDB; 186062at2759; -.
DR PhylomeDB; B3MSG8; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0036098; P:male germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:2001021; P:negative regulation of response to DNA damage stimulus; IEA:EnsemblMetazoa.
DR GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_03065; RTEL1; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR010614; DEAD_2.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR030845; RTEL1.
DR PANTHER; PTHR11472; PTHR11472; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00604; rad3; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase;
KW Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..994
FT /note="Regulator of telomere elongation helicase 1 homolog"
FT /id="PRO_0000370620"
FT DOMAIN 7..316
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT REGION 861..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 252..255
FT /note="DEAH box"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 146
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 164
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 173
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 209
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
SQ SEQUENCE 994 AA; 110230 MW; C3BA78967A959640 CRC64;
MPESLIAGIP VHFPFEPYPV QRAYMEKVIQ CLKDGTNGVL ESPTGTGKTL SLLCSSLAWI
RTRQSEHQQQ MIKLDKGADL LGGGAGGGPE LSDLAKTMGK ANNWGVPKVI YASRTHSQLT
QAMRELKRTA YSNMRSVVLG SRDQLCIHPE VSREVGNSNK VNMCKLRVHS KTCTFQLRVE
SKKDHPDFRG PSIMDIEDLI KVGQKLKMCP YYASKELVPQ ADITFMPYNY LLDPKARKAN
KIELGNTIVI LDEAHNIEKI CEESASVQIK SSDVAIAIED VTHIMKAFAS DSPQDMAGDE
PKDFTIDDLM LLKEMLLDLE KAIDAVAVDN PIDGATYPAS MIYELLGKAN FTYGNVATIV
ALLDKLVQYL MVASQQQMSL RKGGSFTLLS DLLTIVFANK ESVMGKVHAS FKVHVQVEES
KQPQGKQAPA KQAGGWLSKA SLTNGSTGKV AKIINFWCFN PGFGMEQLLN TQVRSVILTS
GTLAPLKPLI AELAIPVAQH LENPHIVDQS QVYVKIIGTG PDRQPLISNY TNRDNPKYIS
SLGQTILNVS RLVPDGLLVF FPSYPMLNKC VDAWQASGLW ADIASKKPIF LEPRGKDQFT
STMEEFYQAI RDSKGACFMA VCRGKVSEGL DFADRNGRAV IITGLPFPPL KDPKVILKRR
YLESNRTREN QLLSGNEWYN LEATRAVNQA IGRVIRHRND YGAILLCDSR FKDAAQVQQL
SKWIRGHLGD RPQCSPFGPI VRELRQFFKN AETTMKQPDE RESGAPLETV IKKEDEPLAP
ISQIKREPGS NATFKAANET AIKVEMANSI KSWSPDDYAC AAGRKLGGSS APNAMDFMSR
LDSNVSSIDF NCMDSRNGSN SSGLVKIHKR ERSSPPGSSQ SSSQTAKKRY KLVENISTIK
VEPPVEVKKE VPESRAAFLR EIRSLVGQDQ FRAFGQALLE YKDGSKDKFE ALMKVVFEVL
GGPRCRHLLV GMRKYIKADD KPEFDIRLAK LEKS
