RTEL1_DROPE
ID RTEL1_DROPE Reviewed; 1009 AA.
AC B4GU19;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Regulator of telomere elongation helicase 1 homolog {ECO:0000255|HAMAP-Rule:MF_03065};
DE EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_03065};
GN ORFNames=GL14463;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: ATP-dependent DNA helicase implicated in DNA repair and the
CC maintenance of genomic stability. Acts as an anti-recombinase to
CC counteract toxic recombination and limit crossover during meiosis.
CC Regulates meiotic recombination and crossover homeostasis by physically
CC dissociating strand invasion events and thereby promotes noncrossover
CC repair by meiotic synthesis dependent strand annealing (SDSA) as well
CC as disassembly of D loop recombination intermediates.
CC {ECO:0000255|HAMAP-Rule:MF_03065}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_03065};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03065}.
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DR EMBL; CH479190; EDW26039.1; -; Genomic_DNA.
DR RefSeq; XP_002022098.1; XM_002022062.1.
DR AlphaFoldDB; B4GU19; -.
DR SMR; B4GU19; -.
DR STRING; 7234.FBpp0178570; -.
DR EnsemblMetazoa; FBtr0180078; FBpp0178570; FBgn0152068.
DR GeneID; 6596883; -.
DR KEGG; dpe:6596883; -.
DR eggNOG; KOG1132; Eukaryota.
DR HOGENOM; CLU_006515_4_0_1; -.
DR OMA; GNCATIV; -.
DR PhylomeDB; B4GU19; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0036098; P:male germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:2001021; P:negative regulation of response to DNA damage stimulus; IEA:EnsemblMetazoa.
DR GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_03065; RTEL1; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR010614; DEAD_2.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR030845; RTEL1.
DR PANTHER; PTHR11472; PTHR11472; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00604; rad3; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase;
KW Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..1009
FT /note="Regulator of telomere elongation helicase 1 homolog"
FT /id="PRO_0000370625"
FT DOMAIN 7..322
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT MOTIF 252..255
FT /note="DEAH box"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 146
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 164
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 173
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 209
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
SQ SEQUENCE 1009 AA; 112191 MW; CED23BED34F270AD CRC64;
MPESVIAGIP VHFPFEPYNV QRDYMEKVII CLRDGTNGVL ESPTGTGKTL SLLCASLAWI
RTRQSEHQQQ MIKLKATSKE GGPGSGPGGD LSELAMTVGQ ANNWGVPKVI YASRTHSQLN
QAMRELKRTA YANMRSVVLG SRDQLCIHPE VMKEQGNSNK VNLCKLRVHS KTCTFQLRVE
SKKDHPDFRG PSIMDIEDLV RVGQKLKMCP YYASKELVAQ ADITFMPYNY LLDPKARKAN
KIELGNTIII LDEAHNIEKI CEESASVQIR SSDVAMAIED VTHIMKVFTS GESQEAGGDE
PKDFTLDDLT LLKEMLLELE KAIDAVVVDN PTDGTTYPAS LMYELLGKAN FTYGNCATIV
ALLDKLVQYL MVASQHMTIR KGGTFTMLSD LLTIVFANKE NIMSKVHLSF KVHVQVEESN
KQQGKSGAIQ GKQQGWLGKG NITTTGTSSK AAKIVNFWCF NPGFGMEQLL NTQVRSVILT
SGTLAPLKPL IAELAIPVAQ HLENPHIVDQ SQVYVKIIGT GPDRQQLISN FKNRDNPKYI
SSLGQTILNV ARIVPDGLLV FFPSYPMLNK CVDAWQASGL WADISCKKPI FVEPRGKDQF
TSTMEEFYQA IRDSKGAVFM AVCRGKVSEG LDFADRNGRA VIITGLPFPP LKDPKVILKR
RYLETNRTKE NQLLSGQEWY NLDATRAVNQ AIGRVIRHRN DYGAILLCDS RFQDASQVQQ
LSKWIRGHLG ARPQSSPFGP IVRELRQFFK HAEETMKQPD VREEEQPLMN VCKVEEVGTQ
PVIPTIKQEP GNNATFRKAN KSAIKVEMAN SINSWTPADY ASAAGRTLGK AAPNAMDFMS
RLDSNVSSID FNCSGSADSG SGGCGSSSLV TIHKRERSSP GVTDTVATQT TKKRYKLAEN
IKTEPKSNSS QQVKVAPESR ADFLRELRSL ISQDQFRDFG KVLIEYRSGT DENFESLMTV
LLDVLAAPKM RYLFIGMRRF LRNEHKAEFD VRLASLNLAQ ESSPNKRIP
