RTEL1_DROSE
ID RTEL1_DROSE Reviewed; 966 AA.
AC B4I0K4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Regulator of telomere elongation helicase 1 homolog {ECO:0000255|HAMAP-Rule:MF_03065};
DE EC=3.6.4.12 {ECO:0000255|HAMAP-Rule:MF_03065};
GN ORFNames=GM12432;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: ATP-dependent DNA helicase implicated in DNA repair and the
CC maintenance of genomic stability. Acts as an anti-recombinase to
CC counteract toxic recombination and limit crossover during meiosis.
CC Regulates meiotic recombination and crossover homeostasis by physically
CC dissociating strand invasion events and thereby promotes noncrossover
CC repair by meiotic synthesis dependent strand annealing (SDSA) as well
CC as disassembly of D loop recombination intermediates.
CC {ECO:0000255|HAMAP-Rule:MF_03065}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_03065};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03065}.
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DR EMBL; CH480819; EDW53035.1; -; Genomic_DNA.
DR RefSeq; XP_002036876.1; XM_002036840.1.
DR AlphaFoldDB; B4I0K4; -.
DR SMR; B4I0K4; -.
DR STRING; 7238.B4I0K4; -.
DR EnsemblMetazoa; FBtr0195417; FBpp0193909; FBgn0167369.
DR HOGENOM; CLU_006515_4_0_1; -.
DR OMA; GNCATIV; -.
DR PhylomeDB; B4I0K4; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0036098; P:male germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:2001021; P:negative regulation of response to DNA damage stimulus; IEA:EnsemblMetazoa.
DR GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_03065; RTEL1; 1.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR010614; DEAD_2.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR030845; RTEL1.
DR PANTHER; PTHR11472; PTHR11472; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00604; rad3; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase;
KW Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..966
FT /note="Regulator of telomere elongation helicase 1 homolog"
FT /id="PRO_0000370627"
FT DOMAIN 7..284
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT REGION 844..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 233..236
FT /note="DEAH box"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 146
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 164
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 173
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT BINDING 209
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03065"
FT MOD_RES 855
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 966 AA; 107500 MW; A36C0CB89EFA78D4 CRC64;
MPESLIAGIP VHFPFEPYPV QRAYMEKVIH CLRDGTNGVL ESPTGTGKTL SLLCSSLAWI
RTRQSEHQMQ MVKMEKADFS GIGGGAPGGD LSELAKTMGR ANNWGVPKVI YASRTHSQLT
QAMRELKRTA YANMRSVVLG SRDQLCIHPE VMRELGNSNK TNMCKLRVHS KTCSFQMRVE
SRKDHPDLRG PTIMDIEDLV KVGQRLKICP YFASRELARA NKIELGNTIV ILDEAHNIEK
ICEEYASVQI KSSDVAMTIE DITHIRQVFA SGESQDMAGD EPKDFTLDDL TLLKEMLLEL
EKAIDAVVVD NAVDGTTFPA SMMYELLGKA NFTYGNVASI ISLLDKLVQY LLVASQQMSI
RKGGTFTLLS DLLTIVFANK EDVMSKVYAS FKVHVLVEES KQGHGKQQGA KQQGGWLGKG
TIAAATGSSK VAKIINFWCF NPGFGMEQLL NTQVRSVILT SGTLAPLKPL IAELAIPVAQ
HLENPHIVDQ SQVYVKIIGT GPDRQQLISN YANRDNPKYV SSLGQTILNV ARIVPDGLLV
FFPSYPMLNK CVDAWQASGL WADISCKKPI FLEPRSKDQF TSTMEEFYQA IRDSKGAVFM
AVCRGKVSEG LDFADRNGRA VIITGLPFPP LKDPKVILKR RYLEANRTRE NQLLSGQEWY
NLDATRAVNQ AIGRVIRHRN DYGAILLCDS RFKDASQVQQ LSKWIRGHLG DRPQCSPFGP
IVRELRQFFK NAEANMKLPD ERETDSPLET VCKTEVEPLA AIPKVKREPG SNATFKSANE
SAIKVEMANS IKTWTPADYA SAAGRKLGGA APNAMDFMSR LDSNVSSIDF NCCTDSKSGS
SGLVKIHKRE RSSPTAPEST SQVSKKRYKL VENIKVEPSS SQAKVAPEDR AAFLRELRSL
VTQDQFRRFG KALLEYKNGT YESFQALMAI LLDVLSAPKV RYMLVGMRKY LKNEHKEEFD
RRVGNL
