RTEL1_ORYSJ
ID RTEL1_ORYSJ Reviewed; 1014 AA.
AC A0A0P0V4R0; B9EXU8; Q0JLK8; Q5ZD38;
DT 20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 1.
DT 03-AUG-2022, entry version 40.
DE RecName: Full=Regulator of telomere elongation helicase 1 homolog {ECO:0000305};
DE EC=3.6.4.12 {ECO:0000305};
GN Name=RTEL1 {ECO:0000305};
GN OrderedLocusNames=Os01g0592900 {ECO:0000312|EMBL:BAS72959.1},
GN LOC_Os01g40980 {ECO:0000305};
GN ORFNames=P0710A02.28-1 {ECO:0000312|EMBL:BAD52706.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP REVIEW, AND IDENTIFICATION.
RX PubMed=21081662; DOI=10.1093/jxb/erq357;
RA Knoll A., Puchta H.;
RT "The role of DNA helicases and their interaction partners in genome
RT stability and meiotic recombination in plants.";
RL J. Exp. Bot. 62:1565-1579(2011).
CC -!- FUNCTION: ATP-dependent DNA helicase implicated in DNA replication, DNA
CC repair and the maintenance of genomic stability. Acts as an anti-
CC recombinase to counteract toxic recombination and limit crossover
CC during meiosis. Regulates meiotic recombination and crossover
CC homeostasis by physically dissociating strand invasion events and
CC thereby promotes noncrossover repair by meiotic synthesis dependent
CC strand annealing (SDSA) as well as disassembly of D loop recombination
CC intermediates. {ECO:0000305}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000305};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK099544; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=AK099544; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAD52706.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF05370.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EEE54911.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP003048; BAD52706.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008207; BAF05370.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014957; BAS72959.1; -; Genomic_DNA.
DR EMBL; CM000138; EEE54911.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK099544; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015640952.1; XM_015785466.1.
DR AlphaFoldDB; A0A0P0V4R0; -.
DR SMR; A0A0P0V4R0; -.
DR STRING; 4530.OS01T0592900-02; -.
DR PaxDb; A0A0P0V4R0; -.
DR EnsemblPlants; Os01t0592900-02; Os01t0592900-02; Os01g0592900.
DR GeneID; 4326378; -.
DR Gramene; Os01t0592900-02; Os01t0592900-02; Os01g0592900.
DR KEGG; osa:4326378; -.
DR eggNOG; KOG1132; Eukaryota.
DR OMA; GNCATIV; -.
DR OrthoDB; 186062at2759; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000007752; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR ExpressionAtlas; A0A0P0V4R0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR GO; GO:0070182; F:DNA polymerase binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:EnsemblPlants.
DR GO; GO:0043007; P:maintenance of rDNA; IEA:EnsemblPlants.
DR GO; GO:0070716; P:mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication; IEA:EnsemblPlants.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR GO; GO:1904430; P:negative regulation of t-circle formation; IBA:GO_Central.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR GO; GO:0000725; P:recombinational repair; IEA:EnsemblPlants.
DR GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0048364; P:root development; IEA:EnsemblPlants.
DR GO; GO:0090657; P:telomeric loop disassembly; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR010614; DEAD_2.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR PANTHER; PTHR11472; PTHR11472; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00604; rad3; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 2: Evidence at transcript level;
KW 4Fe-4S; ATP-binding; DNA damage; DNA repair; DNA replication; DNA-binding;
KW Helicase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding;
KW Nucleus; Reference proteome.
FT CHAIN 1..1014
FT /note="Regulator of telomere elongation helicase 1 homolog"
FT /id="PRO_0000442766"
FT DOMAIN 7..308
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT REGION 70..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 255..258
FT /note="DEAH box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT COMPBIAS 86..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT BINDING 149
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000305"
FT BINDING 170
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000305"
FT BINDING 175
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000305"
FT BINDING 211
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT /evidence="ECO:0000305"
FT CONFLICT 728
FT /note="K -> E (in Ref. 5; AK099544)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1014 AA; 112464 MW; 165C3EA525C94492 CRC64;
MPVYRIRGVD VDFPYDAYDC QITYMDRVLE SLQQGKNALL ESPTGTGKTL CLLCSALAWR
RTFGEFLRGG GGGGGGGGGG GGGGSQQPPY GSQPSGSQHS GGSASQSSRY PVIIYASRTH
SQLRQVIKEL KATSYRPKMA VLGSREQMCI HEEVSKLRGR QQNNACHYLC KKRWCRHHNS
VAEFMRNNSE LGSEACDIED LVNIGRTKGP CPYYISRELS KSVDILFAPY NYLIDPGNRR
SLNGIPWDNA VLIFDEAHNL ESICADAASF DLLPNNLSSC IAEAQECIQL CSAKRTFENS
ADKQFDPENY AILKALLMAL EKKISEVVID SKELGHTKPG NYIYEFLSEL NITSETSKKL
IDTIDGASLL LEEGNSAETG PGMKAKATVC RLETIRDILD IIFRGGGQSH AKYYRFHVNE
CQQNSGDALK VLGKVSRTLS WWCFNPGLAM EEFLKLGVRS IILTSGTLSP LDSLALELNL
EFPVRLENPH VIASDQIWVG VVPVGPSGHP LNSSYRTRET LKYKQELGIT IVNFARIVPD
GLLVFFPSYS MMDKCINCWK DRNHENSSDE HTIWQRICKH KQPVIEPRQS SNFPNAIEDY
AAKLRDSSTT GAIFFAVCRG KVSEGLDFAD RAGRAVIVTG MPFATPTDPK VRLKRDYLDK
LGSASNKNSK ALTGEEWYVQ QAARAVNQAV GRVIRHRHDY GAIIYCDERF VWQNYQSQMS
YWLRPYIKCY KKYGEVVQGL TRFFRDKVSI DSSKPNETDF NDNIVLLADK HKPQETISAL
AVTTANENQR TALSVNPTTK RSNYIKFAQI TPANRSTLSM KHGCSSTSQL LYSGDKLSTD
AQVIDLAADV ATSHLAGYRF KSLGPKKAKV MVGSKDVCFD DGSPKLQHNV ESRALAGCLG
EQSTASSKKS NITHAPGNSG AIHEKSGGQE SNAGPAFLKL AREKLSTAEY RDFVEYMKAL
KLKTMHIKDS LDAIAKLFSS PERLPLLEGF RVFVPKNHLS LYEQLVQSYT VPNT
