RTF2_BOVIN
ID RTF2_BOVIN Reviewed; 299 AA.
AC Q0VCR1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Replication termination factor 2 {ECO:0000305};
DE Short=RTF2;
DE AltName: Full=Replication termination factor 2 domain-containing protein 1;
GN Name=RTF2; Synonyms=RTFDC1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal pons;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Replication termination factor which is a component of the
CC elongating replisome. Required for ATR pathway signaling upon DNA
CC damage and has a positive activity during DNA replication. Might
CC function to facilitate fork pausing at replication fork barriers like
CC the rDNA. May be globally required to stimulate ATR signaling after the
CC fork stalls or encounters a lesion. Interacts with nascent DNA.
CC {ECO:0000250|UniProtKB:Q9BY42}.
CC -!- SUBUNIT: Interacts with DDI2; probably also interacts with DDI1.
CC {ECO:0000250|UniProtKB:Q9BY42}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9BY42}.
CC Note=Localizes at the replication fork. {ECO:0000250|UniProtKB:Q9BY42}.
CC -!- PTM: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from
CC stalled replisomes and degradation are required for genome stability.
CC {ECO:0000250|UniProtKB:Q9BY42}.
CC -!- SIMILARITY: Belongs to the rtf2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC120045; AAI20046.1; -; mRNA.
DR RefSeq; NP_001069093.1; NM_001075625.2.
DR AlphaFoldDB; Q0VCR1; -.
DR STRING; 9913.ENSBTAP00000039110; -.
DR PaxDb; Q0VCR1; -.
DR GeneID; 513536; -.
DR KEGG; bta:513536; -.
DR CTD; 51507; -.
DR eggNOG; KOG3113; Eukaryota.
DR InParanoid; Q0VCR1; -.
DR OrthoDB; 1385322at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005657; C:replication fork; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0072711; P:cellular response to hydroxyurea; ISS:UniProtKB.
DR GO; GO:1902979; P:mitotic DNA replication termination; IEA:InterPro.
DR GO; GO:0097752; P:regulation of DNA stability; ISS:UniProtKB.
DR CDD; cd16653; RING-like_Rtf2; 1.
DR InterPro; IPR006735; Rtf2.
DR InterPro; IPR027799; Rtf2_RING-finger.
DR PANTHER; PTHR12775; PTHR12775; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Phosphoprotein; Reference proteome.
FT CHAIN 1..299
FT /note="Replication termination factor 2"
FT /id="PRO_0000327233"
FT REGION 195..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BY42"
SQ SEQUENCE 299 AA; 33149 MW; E3A8D33DEFF1A29C CRC64;
MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA CELGRLYNKD
AVIEFLLDKS SEKALGKAAS HIKSIKNVTE LRLSDNPAWE GDKGNTKGDK HDDLQRARFI
CPVVGLEMNG RHRFCFLRCC GCVFSERALK EIKAEVCHTC GAAFQEDDVI VLNGTKEDVE
VLKSRIEERR LRAKLGKKTK KPKVAESVSK SEVSEETPGP SKVKTGKPEE TSLDTREKKT
NSAPKSAAAH GITSGKAAKR SIADSEESEA YKSLFTTHSS AKRSKEESAH WVTHTSYCF
