ID   RTF2_DICDI              Reviewed;         273 AA.
AC   Q54IS6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Replication termination factor 2 {ECO:0000305};
DE            Short=RTF2;
DE   AltName: Full=Replication termination factor 2 domain-containing protein 1;
GN   Name=rtf2; Synonyms=rtfdc1; ORFNames=DDB_G0288549;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Replication termination factor which is a component of the
CC       elongating replisome. Interacts with nascent DNA.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9BY42}.
CC       Note=Localizes at the replication fork. {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SIMILARITY: Belongs to the rtf2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000116; EAL63167.1; -; Genomic_DNA.
DR   RefSeq; XP_636671.1; XM_631579.1.
DR   AlphaFoldDB; Q54IS6; -.
DR   STRING; 44689.DDB0267130; -.
DR   PaxDb; Q54IS6; -.
DR   EnsemblProtists; EAL63167; EAL63167; DDB_G0288549.
DR   GeneID; 8626684; -.
DR   KEGG; ddi:DDB_G0288549; -.
DR   dictyBase; DDB_G0288549; -.
DR   eggNOG; KOG3113; Eukaryota.
DR   HOGENOM; CLU_048955_2_0_1; -.
DR   InParanoid; Q54IS6; -.
DR   OMA; EVCHKCG; -.
DR   PhylomeDB; Q54IS6; -.
DR   PRO; PR:Q54IS6; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1902979; P:mitotic DNA replication termination; IEA:InterPro.
DR   CDD; cd16653; RING-like_Rtf2; 1.
DR   InterPro; IPR006735; Rtf2.
DR   InterPro; IPR027799; Rtf2_RING-finger.
DR   PANTHER; PTHR12775; PTHR12775; 1.
PE   3: Inferred from homology;
KW   Chromosome; Reference proteome.
FT   CHAIN           1..273
FT                   /note="Replication termination factor 2"
FT                   /id="PRO_0000327239"
FT   REGION          202..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   273 AA;  30710 MW;  B0BE0B66BA74AC8E CRC64;
     MGLDGGTIPT RCELVKTKKK EVKVFDKDQV DFGKWFLCAL AQDTLSEPIV LDDLGNLFNK
     DNIIEALLNG SLETSKNFSH IRSLRSIYTV NFSPNPAHEK DSTVSPWLCP ITKIEVGSSN
     YKFKFLKTCG HVFSEKAFKE LKNDDSNNNN NNNNNNKKEI DSSKDNLSCF LCSKEYITND
     LITINPSGEE FEQMKVTLQE KLANSKKKSS KKSDKKPDNK KRSLESNLAS ESSFTSNTLA
     QTNEEISKKM KSEAFSSIFK SNSNNDTTKT PNK