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RTF2_MACFA
ID   RTF2_MACFA              Reviewed;         306 AA.
AC   Q4R594;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Replication termination factor 2 {ECO:0000305};
DE            Short=RTF2;
DE   AltName: Full=Replication termination factor 2 domain-containing protein 1;
GN   Name=RTF2; Synonyms=RTFDC1; ORFNames=QccE-12445;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Replication termination factor which is a component of the
CC       elongating replisome. Required for ATR pathway signaling upon DNA
CC       damage and has a positive activity during DNA replication. Might
CC       function to facilitate fork pausing at replication fork barriers like
CC       the rDNA. May be globally required to stimulate ATR signaling after the
CC       fork stalls or encounters a lesion. Interacts with nascent DNA.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SUBUNIT: Interacts with DDI2; probably also interacts with DDI1.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9BY42}.
CC       Note=Localizes at the replication fork. {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- PTM: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from
CC       stalled replisomes and degradation are required for genome stability.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SIMILARITY: Belongs to the rtf2 family. {ECO:0000305}.
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DR   EMBL; AB169650; BAE01731.1; -; mRNA.
DR   AlphaFoldDB; Q4R594; -.
DR   STRING; 9541.XP_005569466.1; -.
DR   eggNOG; KOG3113; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:GOC.
DR   GO; GO:0005657; C:replication fork; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0072711; P:cellular response to hydroxyurea; ISS:UniProtKB.
DR   GO; GO:1902979; P:mitotic DNA replication termination; IEA:InterPro.
DR   GO; GO:0097752; P:regulation of DNA stability; ISS:UniProtKB.
DR   CDD; cd16653; RING-like_Rtf2; 1.
DR   InterPro; IPR006735; Rtf2.
DR   InterPro; IPR027799; Rtf2_RING-finger.
DR   PANTHER; PTHR12775; PTHR12775; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Phosphoprotein; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Replication termination factor 2"
FT                   /id="PRO_0000327234"
FT   REGION          193..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         287
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BY42"
SQ   SEQUENCE   306 AA;  33870 MW;  2E3B1A8818B5193F CRC64;
     MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA CELGRLYNKD
     AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE GDKGNTKGDK HDDLQRARFI
     CPVVGLEMNG RHRFCFLRCC GCVFSERALK EIKAEVCHTC GAAFQEDDVI VLNGTNEDVD
     VLKARMEERR LRAKLEKKTK KPKAAESVSK PDVSEEAPGP SKVKTGKPEE TSLDSREKKN
     NLAPKSAATN ESFSGKAGKP LCGATKRSIA DSEESEAYKS LFTTHSSAKR SKEESAHWVT
     HTSYCF
 
 
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