RTF2_PIG
ID RTF2_PIG Reviewed; 306 AA.
AC A5GFW7; A5GFW6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Replication termination factor 2 {ECO:0000305};
DE Short=RTF2;
DE AltName: Full=Replication termination factor 2 domain-containing protein 1;
GN Name=RTF2; Synonyms=RTFDC1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Porcine genome sequencing project;
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Replication termination factor which is a component of the
CC elongating replisome. Required for ATR pathway signaling upon DNA
CC damage and has a positive activity during DNA replication. Might
CC function to facilitate fork pausing at replication fork barriers like
CC the rDNA. May be globally required to stimulate ATR signaling after the
CC fork stalls or encounters a lesion. Interacts with nascent DNA.
CC {ECO:0000250|UniProtKB:Q9BY42}.
CC -!- SUBUNIT: Interacts with DDI2; probably also interacts with DDI1.
CC {ECO:0000250|UniProtKB:Q9BY42}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9BY42}.
CC Note=Localizes at the replication fork. {ECO:0000250|UniProtKB:Q9BY42}.
CC -!- PTM: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from
CC stalled replisomes and degradation are required for genome stability.
CC {ECO:0000250|UniProtKB:Q9BY42}.
CC -!- SIMILARITY: Belongs to the rtf2 family. {ECO:0000305}.
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DR EMBL; CR956640; CAN13140.1; -; Genomic_DNA.
DR EMBL; CR956640; CAN13141.1; -; Genomic_DNA.
DR RefSeq; NP_001103902.1; NM_001110432.1.
DR RefSeq; XP_005673089.1; XM_005673032.2.
DR AlphaFoldDB; A5GFW7; -.
DR STRING; 9823.ENSSSCP00000007988; -.
DR PaxDb; A5GFW7; -.
DR PeptideAtlas; A5GFW7; -.
DR PRIDE; A5GFW7; -.
DR GeneID; 100126294; -.
DR KEGG; ssc:100126294; -.
DR CTD; 51507; -.
DR eggNOG; KOG3113; Eukaryota.
DR HOGENOM; CLU_048955_1_0_1; -.
DR InParanoid; A5GFW7; -.
DR OMA; EVCHKCG; -.
DR OrthoDB; 1385322at2759; -.
DR TreeFam; TF314621; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; A5GFW7; SS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005657; C:replication fork; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0072711; P:cellular response to hydroxyurea; ISS:UniProtKB.
DR GO; GO:1902979; P:mitotic DNA replication termination; IEA:InterPro.
DR GO; GO:0097752; P:regulation of DNA stability; ISS:UniProtKB.
DR CDD; cd16653; RING-like_Rtf2; 1.
DR InterPro; IPR006735; Rtf2.
DR InterPro; IPR027799; Rtf2_RING-finger.
DR PANTHER; PTHR12775; PTHR12775; 1.
PE 3: Inferred from homology;
KW Chromosome; Phosphoprotein; Reference proteome.
FT CHAIN 1..306
FT /note="Replication termination factor 2"
FT /id="PRO_0000327237"
FT REGION 192..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BY42"
FT CONFLICT 247
FT /note="Missing (in Ref. 1; CAN13140)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 33601 MW; 4F3D6901733991C7 CRC64;
MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA CELGRLYNKD
AVIEFLLDKS SEKALGKAAS HIKSIKNVTE LRLSDNPAWE GDKGSTKGDK HDDLQRARFI
CPVVGLEMNG RHRFCYLRCC GCVFSERALK EIKAEVCHTC GAAFQEDDVI VLNGTKEDVA
MLQTRMEERR LRAKLGKKTK KPKAAESVSK SDISEEAPGP SKMKAGKPEE TSLDSREKKT
SSAPRSAAAH GSSSGKAGKP VCGAPKRSIA DSGESEAYKS LFTTHSSAKR SKEESAHWVT
HTSYCF
