ID   RTF2_PONAB              Reviewed;         306 AA.
AC   Q5R9P9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Replication termination factor 2 {ECO:0000305};
DE            Short=RTF2;
DE   AltName: Full=Replication termination factor 2 domain-containing protein 1;
GN   Name=RTF2; Synonyms=RTFDC1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Replication termination factor which is a component of the
CC       elongating replisome. Required for ATR pathway signaling upon DNA
CC       damage and has a positive activity during DNA replication. Might
CC       function to facilitate fork pausing at replication fork barriers like
CC       the rDNA. May be globally required to stimulate ATR signaling after the
CC       fork stalls or encounters a lesion. Interacts with nascent DNA.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SUBUNIT: Interacts with DDI2; probably also interacts with DDI1.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9BY42}.
CC       Note=Localizes at the replication fork. {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- PTM: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from
CC       stalled replisomes and degradation are required for genome stability.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SIMILARITY: Belongs to the rtf2 family. {ECO:0000305}.
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DR   EMBL; CR857368; CAH89663.1; -; mRNA.
DR   EMBL; CR859334; CAH91511.1; -; mRNA.
DR   RefSeq; NP_001125889.1; NM_001132417.2.
DR   AlphaFoldDB; Q5R9P9; -.
DR   STRING; 9601.ENSPPYP00000012459; -.
DR   GeneID; 100172821; -.
DR   KEGG; pon:100172821; -.
DR   CTD; 51507; -.
DR   eggNOG; KOG3113; Eukaryota.
DR   HOGENOM; CLU_048955_1_0_1; -.
DR   InParanoid; Q5R9P9; -.
DR   OMA; EVCHKCG; -.
DR   OrthoDB; 1385322at2759; -.
DR   TreeFam; TF314621; -.
DR   Proteomes; UP000001595; Chromosome 20.
DR   GO; GO:0005634; C:nucleus; IEA:GOC.
DR   GO; GO:0005657; C:replication fork; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0072711; P:cellular response to hydroxyurea; ISS:UniProtKB.
DR   GO; GO:1902979; P:mitotic DNA replication termination; IEA:InterPro.
DR   GO; GO:0097752; P:regulation of DNA stability; ISS:UniProtKB.
DR   CDD; cd16653; RING-like_Rtf2; 1.
DR   InterPro; IPR006735; Rtf2.
DR   InterPro; IPR027799; Rtf2_RING-finger.
DR   PANTHER; PTHR12775; PTHR12775; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Phosphoprotein; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Replication termination factor 2"
FT                   /id="PRO_0000327235"
FT   REGION          193..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..210
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..256
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         287
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BY42"
SQ   SEQUENCE   306 AA;  33825 MW;  C7FF0529EED182B6 CRC64;
     MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA CELGRLYNKD
     AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE GDKGNTKGDK HDDLQRARFI
     CPVVGLEMNG RHRFCFLRCC GCVFSERALK EIKAEVCHTC GAAFQEDDVI VLNGTKEDVD
     VLKTRMEERR LRAKLEKKTK KPKAAESVSK PDVSEEAPGP SKVKTGKPEE ASLDSREKKT
     NLAPKSTATN ESSSGKAGKP PCGATKRSIA DSEESEAYKS LFTTHSSAKR SKEESAHWVT
     HTSYCF