ID   RTF2_RAT                Reviewed;         306 AA.
AC   Q3T1J8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Replication termination factor 2 {ECO:0000305};
DE            Short=RTF2;
DE   AltName: Full=Replication termination factor 2 domain-containing protein 1;
GN   Name=Rtf2 {ECO:0000312|RGD:1311072}; Synonyms=Rtfdc1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Replication termination factor which is a component of the
CC       elongating replisome. Required for ATR pathway signaling upon DNA
CC       damage and has a positive activity during DNA replication. Might
CC       function to facilitate fork pausing at replication fork barriers like
CC       the rDNA. May be globally required to stimulate ATR signaling after the
CC       fork stalls or encounters a lesion. Interacts with nascent DNA.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SUBUNIT: Interacts with DDI2; probably also interacts with DDI1.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9BY42}.
CC       Note=Localizes at the replication fork. {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- PTM: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from
CC       stalled replisomes and degradation are required for genome stability.
CC       {ECO:0000250|UniProtKB:Q9BY42}.
CC   -!- SIMILARITY: Belongs to the rtf2 family. {ECO:0000305}.
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DR   EMBL; BC101880; AAI01881.1; -; mRNA.
DR   RefSeq; NP_001029062.1; NM_001033890.1.
DR   AlphaFoldDB; Q3T1J8; -.
DR   STRING; 10116.ENSRNOP00000006884; -.
DR   iPTMnet; Q3T1J8; -.
DR   PhosphoSitePlus; Q3T1J8; -.
DR   jPOST; Q3T1J8; -.
DR   PaxDb; Q3T1J8; -.
DR   Ensembl; ENSRNOT00000117578; ENSRNOP00000092936; ENSRNOG00000005083.
DR   GeneID; 296410; -.
DR   KEGG; rno:296410; -.
DR   CTD; 296410; -.
DR   RGD; 1311072; Rtf2.
DR   eggNOG; KOG3113; Eukaryota.
DR   GeneTree; ENSGT00390000010923; -.
DR   HOGENOM; CLU_048955_1_0_1; -.
DR   InParanoid; Q3T1J8; -.
DR   OMA; EVCHKCG; -.
DR   OrthoDB; 1385322at2759; -.
DR   PhylomeDB; Q3T1J8; -.
DR   TreeFam; TF314621; -.
DR   PRO; PR:Q3T1J8; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000005083; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q3T1J8; RN.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005657; C:replication fork; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0072711; P:cellular response to hydroxyurea; ISS:UniProtKB.
DR   GO; GO:1902979; P:mitotic DNA replication termination; IEA:InterPro.
DR   GO; GO:0097752; P:regulation of DNA stability; ISS:UniProtKB.
DR   CDD; cd16653; RING-like_Rtf2; 1.
DR   InterPro; IPR006735; Rtf2.
DR   InterPro; IPR027799; Rtf2_RING-finger.
DR   PANTHER; PTHR12775; PTHR12775; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Phosphoprotein; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Replication termination factor 2"
FT                   /id="PRO_0000327236"
FT   REGION          192..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         287
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BY42"
SQ   SEQUENCE   306 AA;  33812 MW;  235FB6AD2D287E30 CRC64;
     MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEVLRRPIVA CELGRLYNKD
     AVIEFLLDKS AEKALGKATS HIRSIKNVTE LKLSDNPAWE GDKGNTKGDK HDDLQRARFI
     CPVVGLEMNG RHRFCFLRCC GCVFSERALK EIKAEVCHTC GAAFQEEDII VLNGTKEDVE
     MLKRRMEERR LRAKLEKKTK KPKTAESASK LGISQDSAGP SKAKAGKSEE ADPDPREKKS
     SLAPRGTASN GSASGKVGKP PCGALKRSIA DSEESETYKS IFTSHSSAKR SKEESAHWVT
     HTSYCF