RTF2_SCHPO
ID RTF2_SCHPO Reviewed; 240 AA.
AC Q10154;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Replication termination factor 2;
GN Name=rtf2; ORFNames=SPAC1D4.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP SUBCELLULAR LOCATION, INTERACTION WITH PCN1, AND FUNCTION.
RX PubMed=19416828; DOI=10.1073/pnas.0812323106;
RA Inagawa T., Yamada-Inagawa T., Eydmann T., Mian I.S., Wang T.S.,
RA Dalgaard J.Z.;
RT "Schizosaccharomyces pombe Rtf2 mediates site-specific replication
RT termination by inhibiting replication restart.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:7927-7932(2009).
CC -!- FUNCTION: Replication termination factor which mediates replication
CC termination at the site-specific replication barrier RTS1. Stabilizes
CC the replication fork stalled at RTS1 until completion of DNA synthesis
CC by a converging replication fork initiated at a flanking origin.
CC {ECO:0000269|PubMed:19416828}.
CC -!- SUBUNIT: Interacts with pcn1. {ECO:0000269|PubMed:19416828}.
CC -!- INTERACTION:
CC Q10154; Q03392: pcn1; NbExp=3; IntAct=EBI-15777832, EBI-768724;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372,
CC ECO:0000269|PubMed:19416828}.
CC -!- SIMILARITY: Belongs to the rtf2 family. {ECO:0000305}.
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DR EMBL; CU329670; CAA93218.1; -; Genomic_DNA.
DR PIR; T38050; T38050.
DR RefSeq; NP_593022.1; NM_001018421.2.
DR AlphaFoldDB; Q10154; -.
DR SMR; Q10154; -.
DR BioGRID; 278929; 56.
DR DIP; DIP-48846N; -.
DR IntAct; Q10154; 1.
DR STRING; 4896.SPAC1D4.09c.1; -.
DR MaxQB; Q10154; -.
DR PaxDb; Q10154; -.
DR EnsemblFungi; SPAC1D4.09c.1; SPAC1D4.09c.1:pep; SPAC1D4.09c.
DR GeneID; 2542468; -.
DR KEGG; spo:SPAC1D4.09c; -.
DR PomBase; SPAC1D4.09c; rtf2.
DR VEuPathDB; FungiDB:SPAC1D4.09c; -.
DR eggNOG; KOG3113; Eukaryota.
DR HOGENOM; CLU_048955_3_0_1; -.
DR InParanoid; Q10154; -.
DR OMA; EVCHKCG; -.
DR PhylomeDB; Q10154; -.
DR PRO; PR:Q10154; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:1902979; P:mitotic DNA replication termination; IEA:InterPro.
DR GO; GO:0071171; P:site-specific DNA replication termination at RTS1 barrier; IMP:PomBase.
DR CDD; cd16653; RING-like_Rtf2; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR006735; Rtf2.
DR InterPro; IPR027799; Rtf2_RING-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12775; PTHR12775; 1.
PE 1: Evidence at protein level;
KW DNA replication; Nucleus; Reference proteome.
FT CHAIN 1..240
FT /note="Replication termination factor 2"
FT /id="PRO_0000116471"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..206
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 27057 MW; 6C05265CE64DD889 CRC64;
MGNDGGSLPT RNELVKEPGK VPPLDIDFKR SVKSSQFSQC AITDEPLYPP IVSCGLGKLY
NKASILQMLL DRSSVPKSPS HIKSLKDVVQ LQVELDDSGK VLWLCPITRH VMSDTYQFAY
IVPCGHVFEY SALKQFGEKM CFQCNQVYEE KDVIPINPNA EQLKTLSKRL LDLALSEKTH
SLNKASKKSN KNGDKKRKHV SKSNSKHAKH ELRTNRMLDG ENVKSETSVT DMERVKRVKI
