ID   RTFL1_ORYSJ             Reviewed;          94 AA.
AC   P0DO27; Q9FWE1;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   02-JUN-2021, sequence version 1.
DT   03-AUG-2022, entry version 5.
DE   RecName: Full=Small polypeptide ROTUNDIFOLIA LIKE 1 {ECO:0000303|PubMed:15125775};
DE            Short=OsRTFL1 {ECO:0000303|PubMed:15125775};
DE            Short=Small polypeptide ROT-FOUR-LIKE 1 {ECO:0000303|PubMed:15125775};
GN   Name=RTFL1 {ECO:0000303|PubMed:15125775};
GN   ORFNames=OSJNBb0015I11.21 {ECO:0000312|EMBL:AAG13585.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   DISRUPTION PHENOTYPE, AND GENE FAMILY.
RX   PubMed=15125775; DOI=10.1111/j.1365-313x.2004.02078.x;
RA   Narita N.N., Moore S., Horiguchi G., Kubo M., Demura T., Fukuda H.,
RA   Goodrich J., Tsukaya H.;
RT   "Overexpression of a novel small peptide ROTUNDIFOLIA4 decreases cell
RT   proliferation and alters leaf shape in Arabidopsis thaliana.";
RL   Plant J. 38:699-713(2004).
RN   [4]
RP   REVIEW, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Taichung 65;
RX   PubMed=25701405; DOI=10.1007/s10265-015-0703-1;
RA   Guo P., Yoshimura A., Ishikawa N., Yamaguchi T., Guo Y., Tsukaya H.;
RT   "Comparative analysis of the RTFL peptide family on the control of plant
RT   organogenesis.";
RL   J. Plant Res. 128:497-510(2015).
CC   -!- FUNCTION: Small polypeptide acting as a regulatory molecule which
CC       coordinates cellular responses required for differentiation, growth and
CC       development, probably by restricting polar cell proliferation in
CC       lateral organs. {ECO:0000250|UniProtKB:A0A5S6RB44}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7XXN8};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:15125775}.
CC   -!- SIMILARITY: Belongs to the DVL/RTFL small polypeptides family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG13585.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes.; Evidence={ECO:0000305};
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DR   EMBL; AC051633; AAG13585.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; P0DO27; -.
DR   Proteomes; UP000000763; Chromosome 10.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0048367; P:shoot system development; IEA:UniProt.
DR   InterPro; IPR012552; DVL.
DR   Pfam; PF08137; DVL; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Developmental protein; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..94
FT                   /note="Small polypeptide ROTUNDIFOLIA LIKE 1"
FT                   /id="PRO_0000452793"
FT   TRANSMEM        63..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          28..59
FT                   /note="Required for DVL/RTFL small polypeptide activity"
FT                   /evidence="ECO:0000250|UniProtKB:Q7XXN8"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   94 AA;  11144 MW;  604FB4AE14782478 CRC64;
     MRQCASASSS TSRPPEAAGE EGKRRRRRRG WLLQAAAREQ RSRFYIFRRC VAMLLCWYKY
     RNITPYNVVP LGIYGLVWFA TMPKYWQCQT IGKF