ID   RTFL2_ORYSJ             Reviewed;          87 AA.
AC   A0A0P0XL10;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   03-AUG-2022, entry version 19.
DE   RecName: Full=Small polypeptide ROTUNDIFOLIA LIKE 2 {ECO:0000303|PubMed:15125775};
DE            Short=OsRTFL2 {ECO:0000303|PubMed:15125775};
DE            Short=Small polypeptide ROT-FOUR-LIKE 2 {ECO:0000303|PubMed:15125775};
GN   Name=RTFL2 {ECO:0000303|PubMed:15125775};
GN   OrderedLocusNames=Os09g0306632 {ECO:0000312|EMBL:BAT07358.1};
GN   ORFNames=OSNPB_090306632 {ECO:0000312|EMBL:BAT07358.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   DISRUPTION PHENOTYPE, AND GENE FAMILY.
RX   PubMed=15125775; DOI=10.1111/j.1365-313x.2004.02078.x;
RA   Narita N.N., Moore S., Horiguchi G., Kubo M., Demura T., Fukuda H.,
RA   Goodrich J., Tsukaya H.;
RT   "Overexpression of a novel small peptide ROTUNDIFOLIA4 decreases cell
RT   proliferation and alters leaf shape in Arabidopsis thaliana.";
RL   Plant J. 38:699-713(2004).
RN   [4]
RP   REVIEW, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Taichung 65;
RX   PubMed=25701405; DOI=10.1007/s10265-015-0703-1;
RA   Guo P., Yoshimura A., Ishikawa N., Yamaguchi T., Guo Y., Tsukaya H.;
RT   "Comparative analysis of the RTFL peptide family on the control of plant
RT   organogenesis.";
RL   J. Plant Res. 128:497-510(2015).
CC   -!- FUNCTION: Small polypeptide acting as a regulatory molecule which
CC       coordinates cellular responses required for differentiation, growth and
CC       development, probably by restricting polar cell proliferation in
CC       lateral organs. {ECO:0000250|UniProtKB:A0A5S6RB44}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7XXN8};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:15125775}.
CC   -!- SIMILARITY: Belongs to the DVL/RTFL small polypeptides family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP014965; BAT07358.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0P0XL10; -.
DR   EnsemblPlants; Os09t0306632-00; Os09t0306632-00; Os09g0306632.
DR   Gramene; Os09t0306632-00; Os09t0306632-00; Os09g0306632.
DR   eggNOG; ENOG502R44C; Eukaryota.
DR   OMA; HTSHYIL; -.
DR   Proteomes; UP000059680; Chromosome 9.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0048367; P:shoot system development; IEA:UniProt.
DR   InterPro; IPR012552; DVL.
DR   Pfam; PF08137; DVL; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Developmental protein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..87
FT                   /note="Small polypeptide ROTUNDIFOLIA LIKE 2"
FT                   /id="PRO_0000452794"
FT   TRANSMEM        19..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          56..87
FT                   /note="Required for DVL/RTFL small polypeptide activity"
FT                   /evidence="ECO:0000250|UniProtKB:Q7XXN8"
SQ   SEQUENCE   87 AA;  10533 MW;  CE2F452CE8411413 CRC64;
     MAYPLLCHYI KAPHSSFPLI PHTSHYILQL VYLHLFHPLP CTQHSHQTMK IEGRRGQMGR
     LNRAFREKRA RFYIFRRCVI MLLRWSD