RTI1_SCHPO
ID RTI1_SCHPO Reviewed; 371 AA.
AC O42905;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=DNA repair and recombination protein rti1;
DE AltName: Full=Rad twenty-two isogene 1;
DE AltName: Full=Rad22 homolog;
GN Name=rti1; ORFNames=SPBC119.14;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=10512870; DOI=10.1091/mbc.10.10.3331;
RA Suto K., Nagata A., Murakami H., Okayama H.;
RT "A double-strand break repair component is essential for S phase completion
RT in fission yeast cell cycling.";
RL Mol. Biol. Cell 10:3331-3343(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP INTERACTION WITH RPH51 AND RPH54.
RX PubMed=14551247; DOI=10.1091/mbc.e03-05-0288;
RA Catlett M.G., Forsburg S.L.;
RT "Schizosaccharomyces pombe Rdh54 (TID1) acts with Rhp54 (RAD54) to repair
RT meiotic double-strand breaks.";
RL Mol. Biol. Cell 14:4707-4720(2003).
CC -!- FUNCTION: Active in the repair of DNA damage and in mating-type
CC switching. Probably involved in the repair of DNA double-strands
CC breaks. Has a role in promoting S phase completion.
CC {ECO:0000269|PubMed:10512870}.
CC -!- SUBUNIT: Interacts with rph51 and rph54. {ECO:0000269|PubMed:14551247}.
CC -!- INTERACTION:
CC O42905; P36601: rhp51; NbExp=3; IntAct=EBI-1167500, EBI-926960;
CC -!- SIMILARITY: Belongs to the RAD52 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA17929.1; -; Genomic_DNA.
DR PIR; T39312; T39312.
DR RefSeq; NP_595296.1; NM_001021203.2.
DR AlphaFoldDB; O42905; -.
DR SMR; O42905; -.
DR BioGRID; 276658; 14.
DR IntAct; O42905; 3.
DR STRING; 4896.SPBC119.14.1; -.
DR PaxDb; O42905; -.
DR EnsemblFungi; SPBC119.14.1; SPBC119.14.1:pep; SPBC119.14.
DR GeneID; 2540121; -.
DR KEGG; spo:SPBC119.14; -.
DR PomBase; SPBC119.14; rti1.
DR VEuPathDB; FungiDB:SPBC119.14; -.
DR eggNOG; KOG4141; Eukaryota.
DR HOGENOM; CLU_011431_3_0_1; -.
DR InParanoid; O42905; -.
DR OMA; LAFEKCK; -.
DR PhylomeDB; O42905; -.
DR PRO; PR:O42905; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000228; C:nuclear chromosome; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000150; F:DNA strand exchange activity; ISO:PomBase.
DR GO; GO:0003697; F:single-stranded DNA binding; IDA:PomBase.
DR GO; GO:0000730; P:DNA recombinase assembly; ISO:PomBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0045002; P:double-strand break repair via single-strand annealing; IBA:GO_Central.
DR GO; GO:0006312; P:mitotic recombination; IBA:GO_Central.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:PomBase.
DR Gene3D; 3.30.390.80; -; 1.
DR InterPro; IPR004585; DNA_recomb/repair_Rad52.
DR InterPro; IPR041247; Rad52_fam.
DR InterPro; IPR007232; Rad52_Rad59_Rad22.
DR InterPro; IPR042525; Rad52_Rad59_Rad22_sf.
DR PANTHER; PTHR12132; PTHR12132; 1.
DR Pfam; PF04098; Rad52_Rad22; 1.
DR TIGRFAMs; TIGR00607; rad52; 1.
PE 1: Evidence at protein level;
KW DNA damage; DNA recombination; DNA repair; Reference proteome.
FT CHAIN 1..371
FT /note="DNA repair and recombination protein rti1"
FT /id="PRO_0000173893"
FT REGION 346..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 41835 MW; 62280F122A2991B0 CRC64;
MGSLPDQSSC EEFTDSQQDK MTKLLAMQLG PEYISRRSGP GGGSVTYLEA WKAIELANEI
FGFNGWSSSI QDIHVDYVEE TKEKKFNVGI SVIVRVTLKD GSFHEDVGYG SIENCRVKAL
AYEKCKKEGT TDALKRALRN FGSSMGNCLY DKRYIQKILK MAPAQAEFNY DNLLRANKRP
YARFAQKVST PIESHANKSV KLEHKNSIEK KISNVDKPIS DLIENDIHES LPALQNPPIQ
SHSETDLYAD EELDSILMHH ERPPIPESPR VEEFEELLNQ FEGDEKVSVD KIDAHDKMTE
AQVVKIPPVQ FMNARVAAAE NPHIKHEGMA FQLHKKSNSI LKSSNIDHNR SMPIRRPSLT
SNNSANTFST K
