ID   RTKN2_DANRE             Reviewed;         642 AA.
AC   Q5XIZ9; Q568A2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Rhotekin-2;
DE   AltName: Full=Pleckstrin homology domain-containing family K member 1;
DE            Short=PH domain-containing family K member 1;
GN   Name=rtkn2; Synonyms=plekhk1; ORFNames=zgc:92568;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-28 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH92947.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; BC083519; AAH83519.1; -; mRNA.
DR   EMBL; BC092947; AAH92947.1; ALT_SEQ; mRNA.
DR   EMBL; BC098873; AAH98873.1; -; mRNA.
DR   AlphaFoldDB; Q5XIZ9; -.
DR   SMR; Q5XIZ9; -.
DR   STRING; 7955.ENSDARP00000112959; -.
DR   PaxDb; Q5XIZ9; -.
DR   PRIDE; Q5XIZ9; -.
DR   ZFIN; ZDB-GENE-041010-225; rtkn2.
DR   eggNOG; ENOG502QRWR; Eukaryota.
DR   InParanoid; Q5XIZ9; -.
DR   PhylomeDB; Q5XIZ9; -.
DR   PRO; PR:Q5XIZ9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0030097; P:hemopoiesis; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR012966; AHD.
DR   InterPro; IPR011072; HR1_rho-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR030469; RTKN2.
DR   PANTHER; PTHR21538:SF21; PTHR21538:SF21; 1.
DR   Pfam; PF08174; Anillin; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS51860; REM_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..642
FT                   /note="Rhotekin-2"
FT                   /id="PRO_0000309328"
FT   DOMAIN          30..105
FT                   /note="REM-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01207"
FT   DOMAIN          306..413
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          505..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          575..642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..612
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        43
FT                   /note="S -> N (in Ref. 1; AAH92947)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        96
FT                   /note="A -> V (in Ref. 1; AAH92947)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        102
FT                   /note="H -> Q (in Ref. 1; AAH92947)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        441
FT                   /note="T -> M (in Ref. 1; AAH92947)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        524
FT                   /note="S -> N (in Ref. 1; AAH92947)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   642 AA;  72413 MW;  6567C4B50437A4DD CRC64;
     MDPPRDIQHF KRNIASRSTV SSCSSLAMEI KRKKIRESMF FPSEDCDIKE KMEFEMRMRA
     GAYKLMVAST KKEQVLDASR SLLTCNARIK AYMSEAQKRT GHQDFRRPSD SQGQVPCKGK
     VAISGLRIPL FWKDSEHFNS KGNTQRVAVF CLMKIGSEIF DTEMVIADSS MTDICFEGVK
     IFSEVKPDFE LTFELYICGL DEEATFANTP KKLARKLRSS FGRSSGRKLC PLLDGGDPDT
     FLQSNPIPPG ARYSLLAYTT LGLEQAEGSF QSHSLIILQN VEASSWLPLY GNLCCQLVAQ
     PDCMTLDMMS GFLSQQQSIE GLQRRCRLYC VLKAGKISCY YSPEEIQAKV EPILIIPINK
     ETRIRVVEND HQRPGSRLNL INPGNGDSAS HVFIAESPDV LQEWLDSLWQ HIYDQSQWQH
     TCDKLMEIDV LSPRKPPLFL TKQADSVYND LSIGSPGKFE SLTDIIHNKI EETNGRFLIG
     QEEETEPPHW AALFEGSRPI VVQKTVLSPG KESNRSITSP DTGSKKKRRA PPPPPDKLPF
     TSVSTNQEKE NCKGPKPRAG RPSLDAKFSA IIQQLQKSHT STRKNAPLGQ IETGQQPEKR
     AEESDLPEYT KKEYIVDPQP PVPAPRNKLR MSFREKMNPK AW