ID   RTKN2_XENLA             Reviewed;         612 AA.
AC   Q5XGX5;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Rhotekin-2;
DE   AltName: Full=Pleckstrin homology domain-containing family K member 1;
DE            Short=PH domain-containing family K member 1;
GN   Name=rtkn2; Synonyms=plekhk1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC084302; AAH84302.1; -; mRNA.
DR   RefSeq; NP_001088285.1; NM_001094816.1.
DR   AlphaFoldDB; Q5XGX5; -.
DR   SMR; Q5XGX5; -.
DR   DNASU; 495119; -.
DR   GeneID; 495119; -.
DR   KEGG; xla:495119; -.
DR   CTD; 495119; -.
DR   Xenbase; XB-GENE-993322; rtkn2.L.
DR   OrthoDB; 497196at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 495119; Expressed in blastula and 13 other tissues.
DR   GO; GO:0030097; P:hemopoiesis; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR012966; AHD.
DR   InterPro; IPR011072; HR1_rho-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR030469; RTKN2.
DR   PANTHER; PTHR21538:SF21; PTHR21538:SF21; 1.
DR   Pfam; PF08174; Anillin; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00742; Hr1; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS51860; REM_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..612
FT                   /note="Rhotekin-2"
FT                   /id="PRO_0000309329"
FT   DOMAIN          3..79
FT                   /note="REM-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01207"
FT   DOMAIN          285..392
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          483..530
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          574..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   612 AA;  69107 MW;  91EFF002F134B1D0 CRC64;
     MEIKRKKIRE SALFPREDDC LIQEKLDFEI RMRDGICKLL SVSSQKEQLL NAVKNLMVCN
     ARIQNYTAQL RSQMGESNTG NTGRRSSDVG LNERQACPGK VAISGIRIPL MWKDSDHFSN
     KEKTQRHSVF CMLRLGPEIH DTDMVIVDKT MTDICFDNVT VFADARSDFQ LKLELYSCCM
     EDSSIANTPK KLARKLRNSI GKSAGKKFNS ELEATEPEAF LFSTPHMPGA RYSLLAQITF
     TLDSIEDNFR THSLTITGHE DSSFWLPLYG SMCCRLVAQP ACLTDEAMMG FLNQQEMVGG
     LRSYTKFYCV LKGGNLLCYY TPEEINAKVE PALTVPINKE TRIRAVGKDS KSRASSFSVI
     NVVSGEAVTK VFSADCKEEL QKWMEAFWQH FYDLSQWKHC SEKLMKINET SPQKPPLFLT
     REPASVYHDM SIGSPMKLES ITDIIHNKIE ETDGQFLIGP QEESAPAPWA ALFDGNHQLH
     VERNKPPLLS SDDPSTSSNV KAKKRRAPPP PPNKTPFSKL VEGNDPSDKE NIWSRASLVR
     KSFDTKLSAI MHQLQRPMVV PLTPAPPEKI EVTENKAELD TGTQEPIKPV PTPRQKSLRE
     KLDPRVWLQS QV