RTL1_BOVIN
ID RTL1_BOVIN Reviewed; 1331 AA.
AC Q52QI2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Retrotransposon-like protein 1;
DE AltName: Full=Paternally expressed gene 11 protein homolog;
DE AltName: Full=Retrotransposon-derived protein PEG11;
GN Name=RTL1; Synonyms=PEG11;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 511-1280.
RC TISSUE=Placenta;
RA Vuocolo T., Tellam R.L.;
RT "mRNA sequence of bovine PEG11 and PEG11AS.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an essential role in capillaries endothelial cells for
CC the maintenance of feto-maternal interface and for development of the
CC placenta. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AAFC03050876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY986480; AAX84834.1; -; mRNA.
DR RefSeq; NP_001181949.1; NM_001195020.1.
DR AlphaFoldDB; Q52QI2; -.
DR STRING; 9913.ENSBTAP00000055386; -.
DR PaxDb; Q52QI2; -.
DR PRIDE; Q52QI2; -.
DR Ensembl; ENSBTAT00000065107; ENSBTAP00000055386; ENSBTAG00000046585.
DR GeneID; 606737; -.
DR KEGG; bta:606737; -.
DR CTD; 388015; -.
DR VEuPathDB; HostDB:ENSBTAG00000046585; -.
DR VGNC; VGNC:34199; RTL1.
DR eggNOG; KOG0017; Eukaryota.
DR GeneTree; ENSGT00950000183173; -.
DR HOGENOM; CLU_002743_1_0_1; -.
DR InParanoid; Q52QI2; -.
DR OMA; QAHLCQG; -.
DR OrthoDB; 583605at2759; -.
DR TreeFam; TF342365; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000046585; Expressed in placenta and 24 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR032549; DUF4939.
DR InterPro; IPR032567; LDOC1-rel.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR15503; PTHR15503; 1.
DR Pfam; PF16297; DUF4939; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1331
FT /note="Retrotransposon-like protein 1"
FT /id="PRO_0000339232"
FT TRANSMEM 1070..1090
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1117..1137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1309..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..123
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..143
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..989
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 630
FT /note="H -> R (in Ref. 2; AAX84834)"
FT /evidence="ECO:0000305"
FT CONFLICT 797
FT /note="N -> S (in Ref. 2; AAX84834)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1331 AA; 151448 MW; 232D947EC2CD79D7 CRC64;
MMEPSEDSFE TMMERKNPSS KQMESSEGSS NTTVETPPGG RVEAAGLASG LAQEMGEQSI
DLRQDMEEPS SGPHREIKDP PNDLLQDLEE SCEGSHLEEG GPFGGAPGEM EEEEDNPWES
QEDQDYYTDL AESEEDESPE EPDSSTVEVM GMVRSIISLY FRMQDLREQQ RVAEEILMNA
INKGQLPNPK QFSGDRREYH EFIVLCQLIL QSYPRVFCND RLRVGYIISH LSGMAMEWAG
DLLERESSVI DDFPAFLEAM NDTFEYRQAL RVAEDAMFNL RQGDRAAIEY INEFQSLVPT
LGWPDEVLQA HLCQGLKEDI RQYLFRIPQP NSLENLITLV LQIEDKLAER RAILRLLPES
RPRHLTWLDS PVPERWTVST WLPNEFHPGI KRNHLFLLLL VRVNPYHSVA VQALVDSGAT
SNYMDEGFAQ EHYVELYQKP YAESVQTADG SLVGNEPVWL YTEPLVCLHQ NHQESLEFDI
VASSKFSVVL GIKWLQLHAP EIDWVKGRCT FHSPYCLKNC FRPPPPCIAL EHHAVSLLPG
LPHQYSDLAD VFNPKEADEE TSDQPSSDGS DDLSESEPSE LQQAGDSDQS EETFYDCAST
APWEPVGAGT QEKAKQEEFW DPKDMLTSRH DYVQMIPELF DQLHGATWFT KLELRGTIVE
ESMSIHQTED VWKVAFGLEL QDMASYQPFL ICADPIIPQG VIHFILKDMI GLFVVSYGQD
VLVYSMSQEE HYHHVRQVLV RFRYHYVYCS LQRSQFHRHT AEFLGFVVTP KGVKLNKSIV
STITGYPTPG SRKSLRNLME FAFPYRHFVE RFADITEPLV RQLQADLPFY WGDEEQEAFV
GLKRAFRKAP LLYHPKPQNQ FYLQTGVTKT SLHASLIQMD KRTGKKVCCA FYSRNISPME
VEASPAEMKI LPIRAAFMVW CRYLENTEEP IMILLNKEDL ASLNNDRLTV LLPGHWVFFF
THFNFDVMEM PSSEDDQPLP RRQRLGERAQ QRRVATTTRP TMLVTMPAPT GDQSPESEDE
EESEGALHPD EPNGQNLQQG YLALIPVDQI FNSFLAHFSM AQIRAVLLHF YRSLLFWKNL
LAMAALLVML RFRRRLALLP APAADPARPP QRRSLRLFLD ASLLTSSGIA TAVTQLFTQM
PPLVGTNALP AEELAELFLG PGPWQLNALR GLQMTPRFWQ MLCQFFGIRG RALEGTQTHP
SPHQSLAPHV EGDEYVVLRE ALQDDLQRFR QCGLHDGLQD TSQDAQDDVW ALRPRQHLPT
EAEVLARLTY IRSTQGGSVV IHRELTARDL IDFLASVYTQ ALPTLVEASP PREGATLEEL
PSDADEDAGL D
