RTL3_MOUSE
ID RTL3_MOUSE Reviewed; 553 AA.
AC Q6P1Y1;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Retrotransposon Gag-like protein 3 {ECO:0000250|UniProtKB:Q8N8U3};
DE AltName: Full=Zinc finger CCHC domain-containing protein 5 {ECO:0000312|MGI:MGI:2685221};
GN Name=Rtl3 {ECO:0000250|UniProtKB:Q8N8U3};
GN Synonyms=Mar3 {ECO:0000303|PubMed:16093683},
GN MArt3 {ECO:0000303|PubMed:16093683}, Zcchc5 {ECO:0000312|MGI:MGI:2685221};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57B16/J;
RX PubMed=16155747; DOI=10.1007/s00239-004-0332-0;
RA Youngson N.A., Kocialkowski S., Peel N., Ferguson-Smith A.C.;
RT "A small family of sushi-class retrotransposon-derived genes in mammals and
RT their relation to genomic imprinting.";
RL J. Mol. Evol. 61:481-490(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57B16/J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP GENE FAMILY.
RX PubMed=16093683; DOI=10.1159/000084963;
RA Brandt J., Veith A.-M., Volff J.-N.;
RT "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian
RT genomes.";
RL Cytogenet. Genome Res. 110:307-317(2005).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [7]
RP FUNCTION, DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=27446912; DOI=10.3389/fcell.2016.00058;
RA Alonso-Martin S., Rochat A., Mademtzoglou D., Morais J., de Reynies A.,
RA Aurade F., Chang T.H., Zammit P.S., Relaix F.;
RT "Gene expression profiling of muscle stem cells identifies novel regulators
RT of postnatal myogenesis.";
RL Front. Cell Dev. Biol. 4:58-58(2016).
CC -!- FUNCTION: May function as a transcriptional regulator (Probable). Plays
CC a role in postnatal myogenesis, may be involved in the regulation of
CC satellite cells self-renewal (PubMed:27446912).
CC {ECO:0000269|PubMed:27446912, ECO:0000305|PubMed:27446912}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:27446912}.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic myogenic progenitor cells,
CC not expressed in adult and aged satellite cells.
CC {ECO:0000269|PubMed:27446912}.
CC -!- DEVELOPMENTAL STAGE: In myogenic progenitor cells, not expressed during
CC early myogenic development, appears during early formation of the
CC satellite cell pool (from 12.5 dpc to 17.5 dpc), before being
CC completely down-regulated during adquisition of satellite cell
CC quiescence. {ECO:0000269|PubMed:27446912}.
CC -!- MISCELLANEOUS: RTL3 is one of at least 11 genes called Mar or Mart
CC related to long terminal repeat retrotransposons. They do not
CC correspond to functional retrotransposons, but rather to
CC neofunctionalized retrotransposons genes.
CC {ECO:0000269|PubMed:16093683}.
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DR EMBL; BN000781; CAI99161.1; -; Genomic_DNA.
DR EMBL; AL670943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466564; EDL14047.1; -; Genomic_DNA.
DR EMBL; BC064821; AAH64821.1; -; mRNA.
DR CCDS; CCDS30344.1; -.
DR RefSeq; NP_955762.1; NM_199468.1.
DR AlphaFoldDB; Q6P1Y1; -.
DR STRING; 10090.ENSMUSP00000060157; -.
DR iPTMnet; Q6P1Y1; -.
DR PhosphoSitePlus; Q6P1Y1; -.
DR PaxDb; Q6P1Y1; -.
DR PRIDE; Q6P1Y1; -.
DR Antibodypedia; 56109; 75 antibodies from 14 providers.
DR DNASU; 213436; -.
DR Ensembl; ENSMUST00000062010; ENSMUSP00000060157; ENSMUSG00000047686.
DR GeneID; 213436; -.
DR KEGG; mmu:213436; -.
DR UCSC; uc009ubw.1; mouse.
DR CTD; 203430; -.
DR MGI; MGI:2685221; Rtl3.
DR VEuPathDB; HostDB:ENSMUSG00000047686; -.
DR eggNOG; ENOG502S3G3; Eukaryota.
DR GeneTree; ENSGT00940000163808; -.
DR HOGENOM; CLU_045127_0_0_1; -.
DR InParanoid; Q6P1Y1; -.
DR OMA; RREGHLC; -.
DR OrthoDB; 583605at2759; -.
DR PhylomeDB; Q6P1Y1; -.
DR TreeFam; TF335133; -.
DR BioGRID-ORCS; 213436; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q6P1Y1; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q6P1Y1; protein.
DR Bgee; ENSMUSG00000047686; Expressed in efferent duct and 71 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR032567; LDOC1-rel.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR15503; PTHR15503; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..553
FT /note="Retrotransposon Gag-like protein 3"
FT /id="PRO_0000440243"
FT ZN_FING 523..537
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 38..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2..43
FT /evidence="ECO:0000255"
FT COMPBIAS 43..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 61382 MW; F964E1E76675852A CRC64;
MVEDLAASYV TLKLENEILQ AQVKRLMEEN AALQAQIPEL QKSGAVKEHE PLRKPSEAQE
PPESPEFPAA RESQNPWEPP ATTEPGEPTK IREPREPSAI SELREPPEIK EPQEPPETNE
SGESSAITEF RGSPEIKEPH LPPKSKEYWG PQELPMVKES WEPPEALDST AWKPPAVKES
QEIQKALESP ATQRPQASPR GYDLPAVCEA EPTDNQGTPA LKELQSPQLH NPTNDEESQT
VPEYQETSSQ LEPLEHPPPQ ETLEPRVPQE PLDPSDAEEF LELSVPEESL EGLIVARTGT
EQAQCELEAT TLPLEYPLAF SEDFQKLSEF LVQLTSYLRS RGYPTEAALV SFVGSFFSGE
AGRMFQPLLD SQPPLVEQFE RLLRALQDTF DNPESLEVAN QGLPQLRQGE GLAPRYSTRF
HLIAQELDLG ESTLCIQFQE ELASSIQNEL SCTSPATNLS DVIIECVTLE EKASGGVDSS
SSSSEEENGS EGPPTENQPV QATSNRPHLS EAERARRREG HLCLYCGHPG HFARDCPVKP
HRVQQAGNME ARR
