RTL4_HUMAN
ID RTL4_HUMAN Reviewed; 310 AA.
AC Q6ZR62; B2RPG1;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Retrotransposon Gag-like protein 4 {ECO:0000312|HGNC:HGNC:25214};
DE AltName: Full=Mammalian retrotransposon-derived protein 4 {ECO:0000250|UniProtKB:Q3URY0};
DE AltName: Full=Zinc finger CCHC domain-containing protein 16;
GN Name=RTL4 {ECO:0000312|HGNC:HGNC:25214};
GN Synonyms=MAR3, MART4 {ECO:0000250|UniProtKB:Q3URY0}, ZCCHC16 {ECO:0000305};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-27.
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-27.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=16093683; DOI=10.1159/000084963;
RA Brandt J., Veith A.-M., Volff J.-N.;
RT "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian
RT genomes.";
RL Cytogenet. Genome Res. 110:307-317(2005).
CC -!- FUNCTION: Involved in cognitive function in the brain, possibly via the
CC noradrenergic system. {ECO:0000250|UniProtKB:Q3URY0}.
CC -!- INTERACTION:
CC Q6ZR62; O95994: AGR2; NbExp=3; IntAct=EBI-18292412, EBI-712648;
CC -!- MISCELLANEOUS: RTL4 is one of at least 11 genes called Mar or Mart
CC related to long terminal repeat retrotransposons. They do not
CC correspond to functional retrotransposons, but rather to
CC neofunctionalized retrotransposons genes.
CC {ECO:0000269|PubMed:16093683}.
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DR EMBL; AK128465; BAC87453.1; -; mRNA.
DR EMBL; BX088563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137430; AAI37431.1; -; mRNA.
DR EMBL; BC137433; AAI37434.1; -; mRNA.
DR CCDS; CCDS35369.1; -.
DR RefSeq; NP_001004308.2; NM_001004308.2.
DR AlphaFoldDB; Q6ZR62; -.
DR BioGRID; 131082; 2.
DR IntAct; Q6ZR62; 1.
DR STRING; 9606.ENSP00000340590; -.
DR iPTMnet; Q6ZR62; -.
DR PhosphoSitePlus; Q6ZR62; -.
DR BioMuta; RTL4; -.
DR DMDM; 145559545; -.
DR PaxDb; Q6ZR62; -.
DR PRIDE; Q6ZR62; -.
DR Antibodypedia; 569; 13 antibodies from 8 providers.
DR DNASU; 340595; -.
DR Ensembl; ENST00000340433.3; ENSP00000340590.2; ENSG00000187823.3.
DR GeneID; 340595; -.
DR KEGG; hsa:340595; -.
DR UCSC; uc065atq.1; human.
DR CTD; 340595; -.
DR DisGeNET; 340595; -.
DR GeneCards; RTL4; -.
DR HGNC; HGNC:25214; RTL4.
DR HPA; ENSG00000187823; Tissue enhanced (liver).
DR neXtProt; NX_Q6ZR62; -.
DR OpenTargets; ENSG00000187823; -.
DR PharmGKB; PA142670538; -.
DR VEuPathDB; HostDB:ENSG00000187823; -.
DR eggNOG; ENOG502T727; Eukaryota.
DR GeneTree; ENSGT00940000163925; -.
DR HOGENOM; CLU_000384_20_1_1; -.
DR InParanoid; Q6ZR62; -.
DR OMA; ETQLCLY; -.
DR OrthoDB; 583605at2759; -.
DR PhylomeDB; Q6ZR62; -.
DR TreeFam; TF335133; -.
DR PathwayCommons; Q6ZR62; -.
DR SignaLink; Q6ZR62; -.
DR BioGRID-ORCS; 340595; 9 hits in 683 CRISPR screens.
DR ChiTaRS; RTL4; human.
DR GenomeRNAi; 340595; -.
DR Pharos; Q6ZR62; Tdark.
DR PRO; PR:Q6ZR62; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q6ZR62; protein.
DR Bgee; ENSG00000187823; Expressed in liver and 18 other tissues.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR032567; LDOC1-rel.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR15503; PTHR15503; 1.
DR SUPFAM; SSF57756; SSF57756; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..310
FT /note="Retrotransposon Gag-like protein 4"
FT /id="PRO_0000257494"
FT ZN_FING 278..295
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT VARIANT 27
FT /note="L -> P (in dbSNP:rs6568050)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_028917"
FT VARIANT 162
FT /note="D -> Y (in dbSNP:rs7474140)"
FT /id="VAR_053756"
SQ SEQUENCE 310 AA; 34685 MW; B2F4F4EDBD580EAC CRC64;
MEKCTKSSST MQVEPSFLQA ENLILRLQMQ HPTTENTAKR GQVMPALATT VMPVPYSLEH
LTQFHGDPAN CSEFLTQVTT YLTALQISNP ANDAQIKLFF DYLSQQLESC GIISGPDKST
LLKQYENLIL EFQQSFGKPT KQEINPLMNA KFDKGDNSSQ QDPATFHLLA QNLICNETNQ
SGQFEKALAD PNQDEESVTD MMDNLPDLIT QCIQLDKKHS DRPELLQSET QLPLLASLIQ
HQALFSPTDP PPKKGPIQLR EGQLPLTPAK RARQQETQLC LYCSQSGHFT RDCLAKRSRA
PATTNNTAHQ
