ID   RTL5_MOUSE              Reviewed;         599 AA.
AC   Q5DTT4;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Retrotransposon Gag-like protein 5;
DE   AltName: Full=Retrotransposon gag domain-containing protein 4;
GN   Name=Rtl5 {ECO:0000250|UniProtKB:Q5HYW3};
GN   Synonyms=Kiaa2001, Rgag4 {ECO:0000312|MGI:MGI:3045324};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fetal brain;
RA   Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA   Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT   complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT   screening of terminal sequences of cDNA clones randomly sampled from size-
RT   fractionated libraries.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENE FAMILY.
RX   PubMed=16093683; DOI=10.1159/000084963;
RA   Brandt J., Veith A.-M., Volff J.-N.;
RT   "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian
RT   genomes.";
RL   Cytogenet. Genome Res. 110:307-317(2005).
CC   -!- MISCELLANEOUS: RTL5 is one of at least 11 genes called Mar or Mart
CC       related to long terminal repeat retrotransposons. They do not
CC       correspond to functional retrotransposons, but rather to
CC       neofunctionalized retrotransposons genes.
CC       {ECO:0000269|PubMed:16093683}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD90267.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK220436; BAD90267.1; ALT_INIT; mRNA.
DR   CCDS; CCDS30320.1; -.
DR   RefSeq; NP_001265463.1; NM_001278534.1.
DR   RefSeq; XP_006528164.1; XM_006528101.2.
DR   AlphaFoldDB; Q5DTT4; -.
DR   SMR; Q5DTT4; -.
DR   STRING; 10090.ENSMUSP00000109261; -.
DR   iPTMnet; Q5DTT4; -.
DR   PhosphoSitePlus; Q5DTT4; -.
DR   PaxDb; Q5DTT4; -.
DR   PRIDE; Q5DTT4; -.
DR   ProteomicsDB; 256799; -.
DR   Antibodypedia; 51779; 40 antibodies from 8 providers.
DR   DNASU; 331474; -.
DR   Ensembl; ENSMUST00000113631; ENSMUSP00000109261; ENSMUSG00000049191.
DR   Ensembl; ENSMUST00000119076; ENSMUSP00000133001; ENSMUSG00000049191.
DR   Ensembl; ENSMUST00000188731; ENSMUSP00000139504; ENSMUSG00000049191.
DR   GeneID; 331474; -.
DR   KEGG; mmu:331474; -.
DR   UCSC; uc009tyi.3; mouse.
DR   CTD; 340526; -.
DR   MGI; MGI:3045324; Rtl5.
DR   VEuPathDB; HostDB:ENSMUSG00000049191; -.
DR   eggNOG; ENOG502QPW5; Eukaryota.
DR   GeneTree; ENSGT00940000163191; -.
DR   HOGENOM; CLU_039587_0_0_1; -.
DR   InParanoid; Q5DTT4; -.
DR   OMA; WPEIEPF; -.
DR   OrthoDB; 82879at2759; -.
DR   TreeFam; TF337113; -.
DR   BioGRID-ORCS; 331474; 5 hits in 72 CRISPR screens.
DR   ChiTaRS; Rtl5; mouse.
DR   PRO; PR:Q5DTT4; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q5DTT4; protein.
DR   Bgee; ENSMUSG00000049191; Expressed in ventricular zone and 132 other tissues.
DR   ExpressionAtlas; Q5DTT4; baseline and differential.
DR   Genevisible; Q5DTT4; MM.
DR   InterPro; IPR032549; DUF4939.
DR   InterPro; IPR032567; LDOC1-rel.
DR   PANTHER; PTHR15503; PTHR15503; 1.
DR   Pfam; PF16297; DUF4939; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..599
FT                   /note="Retrotransposon Gag-like protein 5"
FT                   /id="PRO_0000259630"
FT   REGION          77..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          377..450
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..91
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..446
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   599 AA;  68721 MW;  4AC0E9FE479B1177 CRC64;
     MSEAAGNLNS LRLANVALRE ELNALRGENV QLGLQLGRAL AEVNSLRGNV SSYIRWPMPI
     VPVLAEENFE FLLNETDPTP EEEEEEEEEV PFLCWPPPRT DPEYVSDDLL INVVQDYTNP
     DGSSDPPLSP SPSQPELHSP MLKEPTFEFL LPPLERPDIE PFSGDPVYLA EFLMQLETFI
     ADHEDHFPGG AERVAFLISF FTGEARDWAI SVTQEGSSLH ANFPRFLDEI RKEFCGPIPS
     RVAKKAIRKL KQGNCTLGSY ADAFQFLAQF LSWDDCRLQN QFLKGLSEIF RKELLWSTEV
     ADLDELILEC VKIERKVRVP KTASLTGVQN SCCPFALIPN EDENEGVEFY SENEGEGEEA
     GGYRLYLKDQ RQHMTAFPQE MREEEEEMRK EEDEMEDEED EDEDEDYEFE EEDEDDDDEE
     EEEEEEEEED KEEEMKNEDS DENKYEEEDE VIVRVLEPEQ EQEREEIEHE HVYVHEHIHA
     HVHTLAAHHH GLHGELMVMD EPVLVDTSTQ TISSAIGYHA ENYLGVSPSV MHSSRQRSQN
     RVPLLEGLPG TNSSFYSPPP LMRHAGRLGQ RQMRRCPSVL FCLTPRQGGH RATQGRIRV