RTL6_HUMAN
ID RTL6_HUMAN Reviewed; 239 AA.
AC Q6ICC9; Q6ZTR1;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Retrotransposon Gag-like protein 6 {ECO:0000312|HGNC:HGNC:13343};
DE AltName: Full=Leucine zipper protein down-regulated in cancer cells-like;
DE AltName: Full=Mammalian retrotransposon-derived protein 6 {ECO:0000250|UniProtKB:Q505G4};
DE AltName: Full=Protein LDOC1L {ECO:0000305};
GN Name=RTL6 {ECO:0000312|HGNC:HGNC:13343};
GN Synonyms=LDOC1L {ECO:0000305}, MAR6, MART6 {ECO:0000250|UniProtKB:Q505G4};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-239.
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP GENE FAMILY.
RX PubMed=16093683; DOI=10.1159/000084963;
RA Brandt J., Veith A.-M., Volff J.-N.;
RT "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian
RT genomes.";
RL Cytogenet. Genome Res. 110:307-317(2005).
CC -!- MISCELLANEOUS: RTL6 is one of at least 11 genes called Mar or Mart
CC related to long terminal repeat retrotransposons. They do not
CC correspond to functional retrotransposons, but rather to
CC neofunctionalized retrotransposons genes.
CC {ECO:0000269|PubMed:16093683}.
CC -!- SIMILARITY: Belongs to the LDOC1 family. {ECO:0000305}.
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DR EMBL; CR456439; CAG30325.1; -; mRNA.
DR EMBL; Z75407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030232; AAH30232.1; -; mRNA.
DR EMBL; AK126304; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS33662.1; -.
DR RefSeq; NP_115663.2; NM_032287.2.
DR AlphaFoldDB; Q6ICC9; -.
DR BioGRID; 123975; 11.
DR IntAct; Q6ICC9; 7.
DR STRING; 9606.ENSP00000340434; -.
DR GlyGen; Q6ICC9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6ICC9; -.
DR PhosphoSitePlus; Q6ICC9; -.
DR BioMuta; RTL6; -.
DR DMDM; 74762303; -.
DR MassIVE; Q6ICC9; -.
DR MaxQB; Q6ICC9; -.
DR PaxDb; Q6ICC9; -.
DR PeptideAtlas; Q6ICC9; -.
DR PRIDE; Q6ICC9; -.
DR ProteomicsDB; 66384; -.
DR Antibodypedia; 333; 116 antibodies from 24 providers.
DR DNASU; 84247; -.
DR Ensembl; ENST00000341255.4; ENSP00000340434.3; ENSG00000188636.4.
DR GeneID; 84247; -.
DR KEGG; hsa:84247; -.
DR MANE-Select; ENST00000341255.4; ENSP00000340434.3; NM_032287.3; NP_115663.2.
DR UCSC; uc003beu.2; human.
DR CTD; 84247; -.
DR DisGeNET; 84247; -.
DR GeneCards; RTL6; -.
DR HGNC; HGNC:13343; RTL6.
DR HPA; ENSG00000188636; Low tissue specificity.
DR neXtProt; NX_Q6ICC9; -.
DR OpenTargets; ENSG00000188636; -.
DR PharmGKB; PA134971270; -.
DR VEuPathDB; HostDB:ENSG00000188636; -.
DR eggNOG; ENOG502R33E; Eukaryota.
DR GeneTree; ENSGT00940000162853; -.
DR HOGENOM; CLU_101832_0_0_1; -.
DR InParanoid; Q6ICC9; -.
DR OMA; TCASNRA; -.
DR OrthoDB; 1526235at2759; -.
DR PhylomeDB; Q6ICC9; -.
DR TreeFam; TF337113; -.
DR PathwayCommons; Q6ICC9; -.
DR SignaLink; Q6ICC9; -.
DR BioGRID-ORCS; 84247; 15 hits in 1077 CRISPR screens.
DR ChiTaRS; LDOC1L; human.
DR GenomeRNAi; 84247; -.
DR Pharos; Q6ICC9; Tbio.
DR PRO; PR:Q6ICC9; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q6ICC9; protein.
DR Bgee; ENSG00000188636; Expressed in endothelial cell and 189 other tissues.
DR Genevisible; Q6ICC9; HS.
DR InterPro; IPR032549; DUF4939.
DR InterPro; IPR032567; LDOC1-rel.
DR PANTHER; PTHR15503; PTHR15503; 2.
DR Pfam; PF16297; DUF4939; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..239
FT /note="Retrotransposon Gag-like protein 6"
FT /id="PRO_0000289097"
FT REGION 82..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..69
FT /evidence="ECO:0000255"
FT COMPBIAS 82..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 26154 MW; DEF1661C6F51FBD8 CRC64;
MVQPQTSKAE SPALAASPNA QMDDVIDTLT SLRLTNSALR REASTLRAEK ANLTNMLESV
MAELTLLRTR ARIPGALQIT PPISSITSNG TRPMTTPPTS LPEPFSGDPG RLAGFLMQMD
RFMIFQASRF PGEAERVAFL VSRLTGEAEK WAIPHMQPDS PLRNNYQGFL AELRRTYKSP
LRHARRAQIR KTSASNRAVR ERQMLCRQLA SAGTGPCPVH PASNGTSPAP ALPARARNL
