RTL6_MOUSE
ID RTL6_MOUSE Reviewed; 243 AA.
AC Q505G4; Q8BNE4;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Retrotransposon Gag-like protein 6 {ECO:0000250|UniProtKB:Q6ICC9};
DE AltName: Full=Mammalian retrotransposon-derived protein 6 {ECO:0000303|PubMed:15716091};
DE AltName: Full=Protein LDOC1L {ECO:0000305};
DE AltName: Full=Protein Sushi-15E3;
GN Name=Rtl6 {ECO:0000250|UniProtKB:Q6ICC9};
GN Synonyms=Ldoc1l {ECO:0000305}, Mar6, Mart6 {ECO:0000303|PubMed:15716091},
GN Sushi-15E3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GENE FAMILY.
RX PubMed=16093683; DOI=10.1159/000084963;
RA Brandt J., Veith A.-M., Volff J.-N.;
RT "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian
RT genomes.";
RL Cytogenet. Genome Res. 110:307-317(2005).
RN [4]
RP IDENTIFICATION.
RX PubMed=16155747; DOI=10.1007/s00239-004-0332-0;
RA Youngson N.A., Kocialkowski S., Peel N., Ferguson-Smith A.C.;
RT "A small family of sushi-class retrotransposon-derived genes in mammals and
RT their relation to genomic imprinting.";
RL J. Mol. Evol. 61:481-490(2005).
RN [5]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=15716091; DOI=10.1016/j.gene.2004.11.022;
RA Brandt J., Schrauth S., Veith A.-M., Froschauer A., Haneke T.,
RA Schultheis C., Gessler M., Leimeister C., Volff J.-N.;
RT "Transposable elements as a source of genetic innovation: expression and
RT evolution of a family of retrotransposon-derived neogenes in mammals.";
RL Gene 345:101-111(2005).
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15716091}.
CC -!- DEVELOPMENTAL STAGE: Expressed at 14.5 dpc.
CC {ECO:0000269|PubMed:15716091}.
CC -!- MISCELLANEOUS: RTL6 is one of at least 11 genes called Mar or Mart
CC related to long terminal repeat retrotransposons. They do not
CC correspond to functional retrotransposons, but rather to
CC neofunctionalized retrotransposons genes. {ECO:0000269|PubMed:15716091,
CC ECO:0000269|PubMed:16093683}.
CC -!- SIMILARITY: Belongs to the LDOC1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC39047.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK083881; BAC39047.1; ALT_SEQ; mRNA.
DR EMBL; BC058638; AAH58638.2; -; mRNA.
DR EMBL; BC094559; AAH94559.1; -; mRNA.
DR EMBL; BN000778; CAI99158.1; ALT_SEQ; Genomic_DNA.
DR CCDS; CCDS37168.1; -.
DR RefSeq; NP_808298.2; NM_177630.3.
DR AlphaFoldDB; Q505G4; -.
DR STRING; 10090.ENSMUSP00000069947; -.
DR iPTMnet; Q505G4; -.
DR PhosphoSitePlus; Q505G4; -.
DR PaxDb; Q505G4; -.
DR PRIDE; Q505G4; -.
DR ProteomicsDB; 256800; -.
DR Antibodypedia; 333; 116 antibodies from 24 providers.
DR DNASU; 223732; -.
DR Ensembl; ENSMUST00000069476; ENSMUSP00000069947; ENSMUSG00000055745.
DR GeneID; 223732; -.
DR KEGG; mmu:223732; -.
DR UCSC; uc007xcc.1; mouse.
DR CTD; 84247; -.
DR MGI; MGI:2675858; Rtl6.
DR VEuPathDB; HostDB:ENSMUSG00000055745; -.
DR eggNOG; ENOG502R33E; Eukaryota.
DR GeneTree; ENSGT00940000162853; -.
DR HOGENOM; CLU_101832_0_0_1; -.
DR InParanoid; Q505G4; -.
DR OMA; TCASNRA; -.
DR OrthoDB; 1526235at2759; -.
DR PhylomeDB; Q505G4; -.
DR TreeFam; TF337113; -.
DR BioGRID-ORCS; 223732; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q505G4; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q505G4; protein.
DR Bgee; ENSMUSG00000055745; Expressed in saccule of membranous labyrinth and 246 other tissues.
DR Genevisible; Q505G4; MM.
DR InterPro; IPR032549; DUF4939.
DR InterPro; IPR032567; LDOC1-rel.
DR PANTHER; PTHR15503; PTHR15503; 2.
DR Pfam; PF16297; DUF4939; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..243
FT /note="Retrotransposon Gag-like protein 6"
FT /id="PRO_0000289098"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..69
FT /evidence="ECO:0000255"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 243 AA; 26660 MW; C4B0413B8CEFEC89 CRC64;
MVQPRTSKTE SPASAPGASA QMDDVVDTLT SLRLTNSALR REASTLRAEK ANLTNMLESV
MAELTLLRTR ARIPGALQIT PPISAITSNG TRPMTTPPTS LPEPFSGDPG QLAGFLMQMD
RFMIFQASRF PGEAERVAFL VSRLTGEAEK WAIPHMQPDS PLRNNYQGFL AELRRTYKSP
LRHSRRAQIR KTSASNRAVR ERERERQMLC RQLAAAGTGS CPVHPASNGT NPAPALPSRG
RNL
