RTL8B_HUMAN
ID RTL8B_HUMAN Reviewed; 113 AA.
AC Q17RB0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Retrotransposon Gag-like protein 8B {ECO:0000312|HGNC:HGNC:33156};
DE AltName: Full=Mammalian retrotransposon derived protein 8B;
GN Name=RTL8B; Synonyms=CXX1C, FAM127C, MAR8B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GENE FAMILY.
RX PubMed=16093683; DOI=10.1159/000084963;
RA Brandt J., Veith A.-M., Volff J.-N.;
RT "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian
RT genomes.";
RL Cytogenet. Genome Res. 110:307-317(2005).
CC -!- INTERACTION:
CC Q17RB0; P13196: ALAS1; NbExp=6; IntAct=EBI-10238588, EBI-3905054;
CC Q17RB0; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-10238588, EBI-10171570;
CC Q17RB0; A1A4E9: KRT13; NbExp=3; IntAct=EBI-10238588, EBI-10171552;
CC Q17RB0; Q86TG7: PEG10; NbExp=3; IntAct=EBI-10238588, EBI-2858265;
CC Q17RB0; Q86TG7-2: PEG10; NbExp=11; IntAct=EBI-10238588, EBI-6259410;
CC Q17RB0; O00560: SDCBP; NbExp=3; IntAct=EBI-10238588, EBI-727004;
CC Q17RB0; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-10238588, EBI-742688;
CC Q17RB0; O75478: TADA2A; NbExp=3; IntAct=EBI-10238588, EBI-742268;
CC Q17RB0; Q9UMX0: UBQLN1; NbExp=6; IntAct=EBI-10238588, EBI-741480;
CC Q17RB0; Q9UMX0-2: UBQLN1; NbExp=3; IntAct=EBI-10238588, EBI-10173939;
CC Q17RB0; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-10238588, EBI-947187;
CC -!- MISCELLANEOUS: RTL8B is one of at least 11 genes called Mar or Mart
CC related to long terminal repeat retrotransposons. They do not
CC correspond to functional retrotransposons, but rather to
CC neofunctionalized retrotransposons genes.
CC {ECO:0000269|PubMed:16093683}.
CC -!- SIMILARITY: Belongs to the FAM127 family. {ECO:0000305}.
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DR EMBL; AL136169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113720; AAI13721.1; -; mRNA.
DR EMBL; BC117393; AAI17394.1; -; mRNA.
DR CCDS; CCDS43996.1; -.
DR RefSeq; NP_001071641.1; NM_001078173.1.
DR AlphaFoldDB; Q17RB0; -.
DR SMR; Q17RB0; -.
DR BioGRID; 137545; 13.
DR IntAct; Q17RB0; 10.
DR STRING; 9606.ENSP00000375268; -.
DR iPTMnet; Q17RB0; -.
DR PhosphoSitePlus; Q17RB0; -.
DR BioMuta; RTL8B; -.
DR jPOST; Q17RB0; -.
DR MassIVE; Q17RB0; -.
DR MaxQB; Q17RB0; -.
DR PaxDb; Q17RB0; -.
DR PeptideAtlas; Q17RB0; -.
DR PRIDE; Q17RB0; -.
DR ProteomicsDB; 61142; -.
DR Antibodypedia; 56315; 87 antibodies from 11 providers.
DR DNASU; 441518; -.
DR Ensembl; ENST00000391440.3; ENSP00000375268.1; ENSG00000212747.5.
DR GeneID; 441518; -.
DR KEGG; hsa:441518; -.
DR MANE-Select; ENST00000391440.3; ENSP00000375268.1; NM_001078173.2; NP_001071641.1.
DR UCSC; uc004eyc.2; human.
DR CTD; 441518; -.
DR GeneCards; RTL8B; -.
DR HGNC; HGNC:33156; RTL8B.
DR HPA; ENSG00000212747; Low tissue specificity.
DR neXtProt; NX_Q17RB0; -.
DR OpenTargets; ENSG00000212747; -.
DR PharmGKB; PA162385922; -.
DR VEuPathDB; HostDB:ENSG00000212747; -.
DR eggNOG; ENOG502RU23; Eukaryota.
DR GeneTree; ENSGT00940000154665; -.
DR HOGENOM; CLU_154949_0_0_1; -.
DR InParanoid; Q17RB0; -.
DR OMA; VFGWVEE; -.
DR OrthoDB; 1526235at2759; -.
DR PhylomeDB; Q17RB0; -.
DR TreeFam; TF337843; -.
DR PathwayCommons; Q17RB0; -.
DR SignaLink; Q17RB0; -.
DR BioGRID-ORCS; 441518; 9 hits in 617 CRISPR screens.
DR ChiTaRS; FAM127C; human.
DR GenomeRNAi; 441518; -.
DR Pharos; Q17RB0; Tdark.
DR PRO; PR:Q17RB0; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q17RB0; protein.
DR Bgee; ENSG00000212747; Expressed in right coronary artery and 100 other tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR InterPro; IPR032549; DUF4939.
DR InterPro; IPR032567; LDOC1-rel.
DR PANTHER; PTHR15503; PTHR15503; 1.
DR Pfam; PF16297; DUF4939; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..113
FT /note="Retrotransposon Gag-like protein 8B"
FT /id="PRO_0000311694"
SQ SEQUENCE 113 AA; 13246 MW; 422EDCABF6CA9205 CRC64;
MEGRVQLMKA LLARPLRPAA RRWRNPIPFP ETFDGDTDRL PEFIVQTSSY MFVDENTFSN
DALKVTFLIT RLTGPALQWV IPYIKKESPL LSDYRGFLAE MKRVFGWEED EDF
