RTL9_HUMAN
ID RTL9_HUMAN Reviewed; 1388 AA.
AC Q8NET4; Q9P2M8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Retrotransposon Gag-like protein 9 {ECO:0000312|HGNC:HGNC:29245};
DE AltName: Full=Retrotransposon gag domain-containing protein 1;
DE AltName: Full=Tumor antigen BJ-HCC-23;
GN Name=RTL9 {ECO:0000312|HGNC:HGNC:29245}; Synonyms=KIAA1318, RGAG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Carcinoma;
RA Dong X.-Y., Chen W.-F.;
RT "Cloning and identification of genes which are differentially expressed in
RT carcinoma.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=16093683; DOI=10.1159/000084963;
RA Brandt J., Veith A.-M., Volff J.-N.;
RT "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian
RT genomes.";
RL Cytogenet. Genome Res. 110:307-317(2005).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC -!- MISCELLANEOUS: RTL9 is one of at least 11 genes called Mar or Mart
CC related to long terminal repeat retrotransposons. They do not
CC correspond to functional retrotransposons, but rather to
CC neofunctionalized retrotransposons genes.
CC {ECO:0000269|PubMed:16093683}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92556.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY121804; AAM82752.1; -; mRNA.
DR EMBL; AB037739; BAA92556.1; ALT_INIT; mRNA.
DR EMBL; BC113670; AAI13671.1; -; mRNA.
DR EMBL; BC117184; AAI17185.1; -; mRNA.
DR CCDS; CCDS14552.1; -.
DR RefSeq; NP_065820.1; NM_020769.2.
DR RefSeq; XP_011529300.1; XM_011530998.2.
DR RefSeq; XP_011529301.1; XM_011530999.2.
DR RefSeq; XP_016885183.1; XM_017029694.1.
DR RefSeq; XP_016885184.1; XM_017029695.1.
DR AlphaFoldDB; Q8NET4; -.
DR SMR; Q8NET4; -.
DR BioGRID; 121588; 11.
DR IntAct; Q8NET4; 8.
DR MINT; Q8NET4; -.
DR STRING; 9606.ENSP00000419786; -.
DR iPTMnet; Q8NET4; -.
DR PhosphoSitePlus; Q8NET4; -.
DR BioMuta; RTL9; -.
DR DMDM; 74715429; -.
DR jPOST; Q8NET4; -.
DR PaxDb; Q8NET4; -.
DR PeptideAtlas; Q8NET4; -.
DR PRIDE; Q8NET4; -.
DR ProteomicsDB; 73213; -.
DR Antibodypedia; 29499; 64 antibodies from 19 providers.
DR DNASU; 57529; -.
DR Ensembl; ENST00000465301.2; ENSP00000419786.2; ENSG00000243978.8.
DR Ensembl; ENST00000540313.1; ENSP00000441452.1; ENSG00000243978.8.
DR GeneID; 57529; -.
DR KEGG; hsa:57529; -.
DR UCSC; uc004eor.2; human.
DR CTD; 57529; -.
DR GeneCards; RTL9; -.
DR HGNC; HGNC:29245; RTL9.
DR HPA; ENSG00000243978; Tissue enhanced (brain, testis).
DR neXtProt; NX_Q8NET4; -.
DR OpenTargets; ENSG00000243978; -.
DR PharmGKB; PA134934891; -.
DR VEuPathDB; HostDB:ENSG00000243978; -.
DR eggNOG; ENOG502RXMW; Eukaryota.
DR GeneTree; ENSGT00730000110943; -.
DR HOGENOM; CLU_005669_0_0_1; -.
DR InParanoid; Q8NET4; -.
DR OMA; SGVMSPW; -.
DR OrthoDB; 158127at2759; -.
DR PhylomeDB; Q8NET4; -.
DR TreeFam; TF334822; -.
DR PathwayCommons; Q8NET4; -.
DR SignaLink; Q8NET4; -.
DR BioGRID-ORCS; 57529; 4 hits in 691 CRISPR screens.
DR GenomeRNAi; 57529; -.
DR Pharos; Q8NET4; Tbio.
DR PRO; PR:Q8NET4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8NET4; protein.
DR Bgee; ENSG00000243978; Expressed in right testis and 55 other tissues.
DR ExpressionAtlas; Q8NET4; baseline and differential.
DR Genevisible; Q8NET4; HS.
DR InterPro; IPR042919; RTL9.
DR PANTHER; PTHR47702; PTHR47702; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..1388
FT /note="Retrotransposon Gag-like protein 9"
FT /id="PRO_0000259627"
FT REGION 491..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1100..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1336..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1349..1379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 777
FT /note="P -> S (in dbSNP:rs35495390)"
FT /id="VAR_051318"
SQ SEQUENCE 1388 AA; 144280 MW; 19A18E68DC8C5A06 CRC64;
MSIPLHSLRF NNTMREENVE PQNKQMAFCR PMTETRADVQ ILHSHVQLPI VSTSASDPGG
TSTQLMTSPV FDTMSAPLMG VPNSGALSPP LMPASDSGAL SPLLMPASDS GALSPLLMPA
LDSGTLSPLL STSEYGVMSP GMMTIPDFGT MSATLMVAPD SAEISPLAMP APSSGVVCTP
IMSTSSSEAM STPLMLAPDS GELSPILMQD MNPGVMSTQP VPAPSSEAMS PLQITDEDTE
AMSKVLMTAL ASGEISSLLM SGTDSEAISS LIMSAVASGG TSPQPTSTQN SGGIPTPLMS
DLDSGIMSSL LMSSPGSEVM STPLLSVPDA GEMSTLPKPA PDAEAMSPAL MTALPSGVMP
TQTMPAPGSG AMSPWSTQNV DSEMMSNPPV RATASGVMSA PPVRALDSGA MSTPLMGAPA
SGNMSTLQKT VPASGAMTTS LMTVPSSGVM STEQMSATAS RVMSAQLTMA KTSGAMPTGS
MKAVAKQYKR ATASGKMSTP LRRAPTSGAM STQPVTATAS ETMSMPQLTV PASGSMSMLQ
MRAPVSEAMS MPQMRTMASG LTSAAQMKAM TSGAMSTPLM TAQTSGSTST LLMRDTASGV
MSCPQMRSLA SGALSKPLMT PKASGTMFTE KMTTTASEAM PTLLMRDTVS GALSMPQMTD
TASGGLSASL MRDTASGAMS TSQMTATVSG GMSMPLMRAQ DPGVMPASLM RAKVSGKMLS
QPMSTQDPGG MSMSPMKSMT AGGMQMNSPT SDVMSTPTVR AWTSETMSTP LMRTSDPGER
PSLLTRASSS GEMSLPLMRA PASGEIATPL RSPAYGAMSA PQMTATASGM MSSMPQVKAP
ISGAMSMPLT RSTASGGMSM PLMRAPDSRV TSTSQMMPTA SGDMCTLPVR APASGGVSSP
LVRAPASGTM STPLRRPSAC ETVSTELMRA SASGHMSTAQ TTAMVSGGMS KPLMRAPASG
TMPMPLMSAM ASGEMSMPLM ETMASGATST LQTSVANSRS MSLSQTTYTV SGRMATAPIR
ASASGARSTS FMRASVSGSM PMPLPRATAS GCGMGMSMPQ MTATDSRGMS TPLMRASGPG
TMSTPQTAFG VMSTPEIKAT DSGEASTSHI NITASGSKPT SHMTATTPET AKPPPKEVPS
FGMLTPALCY LLEEQEAARG SCSVEEEMEI DEEKQMKGFL DDSERMAFLV SLHLGAAERW
FILQMEVGEP LSHENKSFLR RSQGIYDSLS EIDILSAVLC HPKQGQKSVR QYATDFLLLA
RHLSWSDAIL RTRFLEGLSE AVTTKMGRIF LKVAGSLKEL IDRSLYTECQ LAEEKDSPGN
SSQVLPTACK RNNEEAMGNE LSSQQQTEEH QHVSKRCYYL KEHGDPQEGL HDHLGQSTGH
HQKAHTNK
