RTL9_MOUSE
ID RTL9_MOUSE Reviewed; 1339 AA.
AC Q32KG4; Q5DTY8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Retrotransposon Gag-like protein 9 {ECO:0000250|UniProtKB:Q8NET4};
DE AltName: Full=Retrotransposon gag domain-containing protein 1 {ECO:0000312|MGI:MGI:2685231};
DE AltName: Full=Sushi-XF2 {ECO:0000305};
GN Name=Rtl9 {ECO:0000250|UniProtKB:Q8NET4};
GN Synonyms=Gm385, Kiaa1318, Rgag1 {ECO:0000312|MGI:MGI:2685231};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 211-1339 (ISOFORM 2).
RC TISSUE=Brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GENE FAMILY.
RX PubMed=16093683; DOI=10.1159/000084963;
RA Brandt J., Veith A.-M., Volff J.-N.;
RT "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian
RT genomes.";
RL Cytogenet. Genome Res. 110:307-317(2005).
RN [4]
RP IDENTIFICATION OF ISOFORM 1.
RX PubMed=16155747; DOI=10.1007/s00239-004-0332-0;
RA Youngson N.A., Kocialkowski S., Peel N., Ferguson-Smith A.C.;
RT "A small family of sushi-class retrotransposon-derived genes in mammals and
RT their relation to genomic imprinting.";
RL J. Mol. Evol. 61:481-490(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q32KG4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q32KG4-2; Sequence=VSP_021488;
CC -!- MISCELLANEOUS: RTL8C is one of at least 11 genes called Mar or Mart
CC related to long terminal repeat retrotransposons. They do not
CC correspond to functional retrotransposons, but rather to
CC neofunctionalized retrotransposons genes.
CC {ECO:0000269|PubMed:16093683}.
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DR EMBL; AL731548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK220382; BAD90439.1; -; mRNA.
DR EMBL; BN000782; CAI99162.1; -; Genomic_DNA.
DR CCDS; CCDS72442.1; -. [Q32KG4-2]
DR RefSeq; NP_001035524.2; NM_001040434.2. [Q32KG4-2]
DR RefSeq; XP_011246109.1; XM_011247807.1. [Q32KG4-2]
DR RefSeq; XP_011246110.1; XM_011247808.1. [Q32KG4-2]
DR AlphaFoldDB; Q32KG4; -.
DR SMR; Q32KG4; -.
DR BioGRID; 229088; 9.
DR STRING; 10090.ENSMUSP00000128287; -.
DR iPTMnet; Q32KG4; -.
DR PhosphoSitePlus; Q32KG4; -.
DR PaxDb; Q32KG4; -.
DR PRIDE; Q32KG4; -.
DR ProteomicsDB; 256801; -. [Q32KG4-1]
DR ProteomicsDB; 256802; -. [Q32KG4-2]
DR Antibodypedia; 29499; 64 antibodies from 19 providers.
DR Ensembl; ENSMUST00000165829; ENSMUSP00000128287; ENSMUSG00000085584. [Q32KG4-2]
DR GeneID; 209540; -.
DR KEGG; mmu:209540; -.
DR UCSC; uc009umd.3; mouse. [Q32KG4-2]
DR CTD; 57529; -.
DR MGI; MGI:2685231; Rtl9.
DR VEuPathDB; HostDB:ENSMUSG00000085584; -.
DR eggNOG; ENOG502RXMW; Eukaryota.
DR GeneTree; ENSGT00730000110943; -.
DR HOGENOM; CLU_005669_0_0_1; -.
DR InParanoid; Q32KG4; -.
DR OMA; SGVMSPW; -.
DR OrthoDB; 158127at2759; -.
DR TreeFam; TF334822; -.
DR BioGRID-ORCS; 209540; 0 hits in 67 CRISPR screens.
DR PRO; PR:Q32KG4; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q32KG4; protein.
DR Bgee; ENSMUSG00000085584; Expressed in hypothalamus and 22 other tissues.
DR InterPro; IPR042919; RTL9.
DR PANTHER; PTHR47702; PTHR47702; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1339
FT /note="Retrotransposon Gag-like protein 9"
FT /id="PRO_0000259628"
FT REGION 533..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1330..1339
FT /note="VIKGTYAHGF -> HQHVPKRCYYLKEHGDPQESLHDHLRQSAGLPKAPTNK
FT (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_021488"
SQ SEQUENCE 1339 AA; 138467 MW; E221A8788CEAC9DF CRC64;
MADMSIPLHS LRFNNMMKEE NGDPQNRGAT FSRPMTETRA EVQILHSQLQ LPVVSTSASD
LEGTSTQLMT SPGFDSLSTP LMGAPHSGTL SPPLMSASDS GTLSPLLMPA SDSGTLSPLL
MPVSDSGTLS PLLMPASDSG TLSPLLSTSD YGLMSPGMMS IPDFGTMSSL MAAPDSAEIS
PLAMPIQSSG VISAPIMSTS SSEASLMLGS DPGEISPLLI PDMNPGVTST PPMTAPGSEA
MSPLQITDED TEAMSKVLMT ALASGEISSL LMSGTDSEAI SSLIMSALAS GETPAQPTNP
PESEGIPTVL MSGSDSAVMS SLPMPVSGSG AMPTPLLSIP DAGEIATLPK PVPDVEAMSP
LLMTALTSTV MPSQLISASS SGVMSPDTTQ NINSEVMSAP PIRVSSTGLM STLPVRASDT
AATPIQLMRV PASGNMSTSQ KTVPVSGSMS TPLMAVTSPG AIFTEQMPST ASGTMSTHLT
MPQTPGTMPI GFMKSTSNGA VSAQQIRCSV SGMMSTQPVI ATASEIMSVS QSTVPTSGSV
STQKTRAPVS GPMSTTQIRT TASALTSTPQ MRATASGTMS IPLMTAKTSG SASTLLMRDT
ASGVISVPQM RAPGSGTVSK PLMTSKASGM FMQQMTTAAF GATPTSLMRD TASGGLSMPQ
MTDPASGGMS TLLTRATASG TKSTSQMTAT TSGGIFMPQT RLSGPGATST PLMRATASEK
MPSQAMNIQD SGGVSTPLMR PVALGGVQMR SQGSGTMSTP LLRASDSSEM SMLLTKAPSS
GERPLLLVRP PASGEIAPHS RTPVYGTISA PHMTTTASGV MTMSPMKTSV PVSESATLLR
PTDSGVMSIP LTRTPASRAK SRPQMATACG DMCPLPVRAP ATAGISPSPV RSPASSTLST
LLRRPSDGAV TAELERVLGP AQFAAMTPGE MSKPLMRASA PGTTTMPLMS PMTSGEMSMP
LMKTTPSGTM STLQTKVMSS RATSLPQPRN AASGVIANPP QRAPASGAGS TPLMRVSGSG
MMSTPLLGAT ASGGMSMPQM APPTSGDMFS PLMRSPAPGI MSTPQTAFGM TPTLNVKATD
SGEASTSHTR FTAPGSKSTP HMTSTAPEMK TPPPKEVPSF GMLTPALCYL LEEQEAARGS
SSVEEDAEEI DEEKQMKGFL DDSEKMAFLV SLHLGAAERW SILQMEVGNP ISSDNKAFLR
RSQGLYDSLS EIDILSAVLC HPKQGKKSVR QYATDFLLLA RHLSWSDAIL RTRFLEGLSE
AVTTKMGRIF LKVAGSLKEL IDRSLYTECQ LAEEKDSSGN SNQVVPTSCK RNNEEAMENE
LGSQQQTEEV IKGTYAHGF
