ID   RTM2B_ARATH             Reviewed;         364 AA.
AC   D9UBX6;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Inactive protein RESTRICTED TEV MOVEMENT 2;
DE   AltName: Full=Inactive restricted tobacco etch virus movement protein 2;
GN   Name=RTM2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=cv. Bl-1, and cv. Sakata; TISSUE=Leaf;
RX   PubMed=22723957; DOI=10.1371/journal.pone.0039169;
RA   Cosson P., Schurdi-Levraud V., Le Q.H., Sicard O., Caballero M., Roux F.,
RA   Le Gall O., Candresse T., Revers F.;
RT   "The RTM resistance to potyviruses in Arabidopsis thaliana: natural
RT   variation of the RTM genes and evidence for the implication of additional
RT   genes.";
RL   PLoS ONE 7:E39169-E39169(2012).
CC   -!- FUNCTION: Seems to not be involved in heat resistance (By similarity).
CC       Unable to mediate restriction of long-distance movement of the
CC       pathogenic tobacco etch virus (TEV) without causing a hypersensitive
CC       response or inducing systemic acquired resistance. {ECO:0000250,
CC       ECO:0000269|PubMed:22723957}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}. Note=Present in sieve elements. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
CC   -!- CAUTION: Has been shown to be active in cv. Columbia (AC Q9M670) due to
CC       naturally occurring sequence variation in this strain. The sequence
CC       shown is from strains cv. Bl-1 and cv. Sakata. {ECO:0000305}.
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DR   EMBL; FR682047; CBW45858.1; -; Genomic_DNA.
DR   EMBL; FR682067; CBW45878.1; -; Genomic_DNA.
DR   AlphaFoldDB; D9UBX6; -.
DR   SMR; D9UBX6; -.
DR   ExpressionAtlas; D9UBX6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR045045; RTM2-like.
DR   PANTHER; PTHR43670; PTHR43670; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Plant defense; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..364
FT                   /note="Inactive protein RESTRICTED TEV MOVEMENT 2"
FT                   /id="PRO_0000429167"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          14..121
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   REPEAT          129..133
FT                   /note="A-1"
FT   REPEAT          135..139
FT                   /note="A-2"
FT   REPEAT          156..160
FT                   /note="A-3"
FT   REPEAT          163..176
FT                   /note="B-1"
FT   REPEAT          178..191
FT                   /note="B-2"
FT   REPEAT          193..205
FT                   /note="B-3"
FT   REPEAT          206..210
FT                   /note="A-4"
FT   REPEAT          211..215
FT                   /note="A-5"
FT   REPEAT          216..220
FT                   /note="A-6"
FT   REGION          129..220
FT                   /note="6 X 5 AA repeats A of L-E-E-[SKR]-[ERK]"
FT   REGION          163..206
FT                   /note="3 X 14 AA repeats B of [IMA]-[RK]-K-L-Q-E-E-A-K-A-K-
FT                   E-[EK]-[LA]"
FT   REGION          345..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  41152 MW;  770AEE87EF4B74F3 CRC64;
     MAARQQQKGT GFGVQYEDFV PKSEWKDQPE ATILNIDLTG FAKEQMKVTY VHSSKMIRVT
     GERPLANRKW SRFNEVFTVP QNCLVDKIHG SFKNNVLTIT MPKETITKVA YLPETSRTEA
     AALEKAAKLE EKRLLEESRR KEKEEEEAKQ MKKQLLEEKE ALIRKLQEEA KAKEEAEMRK
     LQEEAKAKEE AAAKKLQEEI EAKEKLEERK LEERRLEERK LEDMNLAEEA KLKKIQERKS
     VDESGEKEKI LKPEVVYTKS GHVATPKPES GSGLKSGFGG VGEVVKSAEE KLGNLVEKEK
     KMGKGIMEKI RRKEITSEEK KLMMNVGVAA LVIFALGAYV SYTFCSSSSS SSSPSSSSSS
     TKPE