ID   RTN1A_XENLA             Reviewed;         207 AA.
AC   Q6IFY7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Reticulon-1-A;
DE   AltName: Full=RTN1.1;
DE            Short=xRTN1;
DE   AltName: Full=XRTN1-C.1;
GN   Name=rtn1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAO60242.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Head {ECO:0000269|PubMed:17969151};
RX   PubMed=17969151; DOI=10.1002/dvdy.21362;
RA   Park E.C., Shim S., Han J.-K.;
RT   "Identification and expression of XRTN1-A and XRTN1-C in Xenopus laevis.";
RL   Dev. Dyn. 236:3545-3553(2007).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305, ECO:0000312|EMBL:DAA02070.1}
RP   IDENTIFICATION.
RX   PubMed=12832288; DOI=10.1096/fj.02-1166hyp;
RA   Oertle T., Klinger M., Stuermer C.A.O., Schwab M.E.;
RT   "A reticular rhapsody: phylogenic evolution and nomenclature of the
RT   RTN/Nogo gene family.";
RL   FASEB J. 17:1238-1247(2003).
CC   -!- FUNCTION: Inhibits amyloid precursor protein processing, probably by
CC       blocking BACE1 activity. {ECO:0000250|UniProtKB:Q16799}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:17969151}; Multi-pass membrane protein
CC       {ECO:0000255}. Nucleus {ECO:0000269|PubMed:17969151}. Note=Mainly
CC       localized to the endoplasmic reticulum with some expression in the
CC       nucleus and polysome fractions. {ECO:0000269|PubMed:17969151}.
CC   -!- TISSUE SPECIFICITY: Expressed in the animal hemisphere (presumptive
CC       neural ectoderm) of blastula and gastrula stage embryos, and along the
CC       anterior neural border, in the panplacodal primordium, and in the
CC       dorsolateral side of archenteron roof of late neurula embryos. At the
CC       tailbud stage, expression localizes to the central nervous system,
CC       including the spinal cord, prosencephalon, mesencephalon and
CC       rhombencephalon, as well as the lateral line placode, otic vesicle and
CC       pronephros. {ECO:0000269|PubMed:17969151}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       {ECO:0000269|PubMed:17969151}.
CC   -!- MISCELLANEOUS: This sequence corresponds to isoform C of rtn1-B.
CC       {ECO:0000269|PubMed:17969151}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY182251; AAO60242.1; -; mRNA.
DR   EMBL; CD360654; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK004007; DAA02070.1; -; mRNA.
DR   RefSeq; NP_001089006.1; NM_001095537.1.
DR   AlphaFoldDB; Q6IFY7; -.
DR   SMR; Q6IFY7; -.
DR   MaxQB; Q6IFY7; -.
DR   GeneID; 496390; -.
DR   KEGG; xla:496390; -.
DR   CTD; 496390; -.
DR   Xenbase; XB-GENE-6252069; rtn1.L.
DR   OrthoDB; 1106300at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 496390; Expressed in brain and 15 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   InterPro; IPR003388; Reticulon.
DR   Pfam; PF02453; Reticulon; 1.
DR   PROSITE; PS50845; RETICULON; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..207
FT                   /note="Reticulon-1-A"
FT                   /id="PRO_0000315932"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          21..207
FT                   /note="Reticulon"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
SQ   SEQUENCE   207 AA;  23629 MW;  418C768A17408DFC CRC64;
     MQASADSTRM ECLWSNWKCQ AIDLLYWRDI KQTGIVFGSV LLMLFSLIQF SVVSVMAYLA
     LAALSATISF RIYKSVLQAV QKTDEGHPFK SYLDMEISLS QEQIQKYTDC LQVYTNSIAK
     ELRRLFLVQD LVDSLKFAVL MWLLTYVGAL FNGLTLLIMA VVSMFSLPVV YDKYQAQIDQ
     YLGLVRTNMN TIMTKIQAKI PGTKQKE