RTN1B_XENLA
ID RTN1B_XENLA Reviewed; 752 AA.
AC Q5MY90; Q5QT55; Q5XHE9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=Reticulon-1-B;
DE AltName: Full=RTN1.2;
DE Short=xRTN1;
GN Name=rtn1-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAR33041.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND C), SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RC TISSUE=Head {ECO:0000269|PubMed:17969151};
RX PubMed=17969151; DOI=10.1002/dvdy.21362;
RA Park E.C., Shim S., Han J.-K.;
RT "Identification and expression of XRTN1-A and XRTN1-C in Xenopus laevis.";
RL Dev. Dyn. 236:3545-3553(2007).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAH84108.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
RC TISSUE=Brain {ECO:0000312|EMBL:AAH84108.1}, and Eye;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA05162.1}
RP IDENTIFICATION (ISOFORM C).
RX PubMed=15858203; DOI=10.1093/molbev/msi158;
RA Diekmann H., Klinger M., Oertle T., Heinz D., Pogoda H.-M., Schwab M.E.,
RA Stuermer C.A.O.;
RT "Analysis of the reticulon gene family demonstrates the absence of the
RT neurite growth inhibitor Nogo-A in fish.";
RL Mol. Biol. Evol. 22:1635-1648(2005).
CC -!- FUNCTION: Inhibits amyloid precursor protein processing, probably by
CC blocking BACE1 activity. {ECO:0000250|UniProtKB:Q16799}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:17969151}; Multi-pass membrane protein
CC {ECO:0000255}. Nucleus {ECO:0000269|PubMed:17969151}. Note=Mainly
CC localized to the endoplasmic reticulum with some expression in the
CC nucleus and polysome fractions. {ECO:0000269|PubMed:17969151}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A {ECO:0000269|PubMed:17969151};
CC IsoId=Q5MY90-1; Sequence=Displayed;
CC Name=C {ECO:0000269|PubMed:15858203, ECO:0000269|PubMed:17969151};
CC Synonyms=C.2 {ECO:0000269|PubMed:17969151};
CC IsoId=Q5MY90-2; Sequence=VSP_052646, VSP_052647;
CC -!- TISSUE SPECIFICITY: Isoform A and isoform C are both expressed in the
CC animal hemisphere (presumptive neural ectoderm) of blastula and
CC gastrula stage embryos, and along the anterior neural border, in the
CC panplacodal primordium, and in the dorsolateral side of archenteron
CC roof of late neurula embryos. At the tailbud stage, expression of the
CC isoforms begin to differ. Isoform A localizes to the cranial placodes
CC including the trigeminal placode, lateral line placode, olfactory
CC placode and otic vesicle. Isoform C localizes to the central nervous
CC system, including the spinal cord, prosencephalon, mesencephalon and
CC rhombencephalon, as well as the lateral line placode, otic vesicle and
CC pronephros. {ECO:0000269|PubMed:17969151}.
CC -!- DEVELOPMENTAL STAGE: Isoform A and isoform C are expressed both
CC maternally and zygotically. {ECO:0000269|PubMed:17969151}.
CC -!- INDUCTION: Isoform A is repressed by thyroid hormone.
CC {ECO:0000269|PubMed:17969151}.
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DR EMBL; AY484582; AAR33041.1; -; mRNA.
DR EMBL; AF498369; AAQ07265.1; -; mRNA.
DR EMBL; BC084108; AAH84108.1; -; mRNA.
DR EMBL; CD326067; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK004058; DAA05162.1; -; mRNA.
DR RefSeq; NP_001089011.1; NM_001095542.1. [Q5MY90-1]
DR RefSeq; XP_018087597.1; XM_018232108.1. [Q5MY90-2]
DR AlphaFoldDB; Q5MY90; -.
DR SMR; Q5MY90; -.
DR GeneID; 496397; -.
DR KEGG; xla:496397; -.
DR CTD; 496397; -.
DR Xenbase; XB-GENE-1011340; rtn1.S.
DR OrthoDB; 244299at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 496397; Expressed in brain and 17 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR InterPro; IPR003388; Reticulon.
DR Pfam; PF02453; Reticulon; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Nucleus;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..752
FT /note="Reticulon-1-B"
FT /id="PRO_0000315933"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 684..704
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 566..752
FT /note="Reticulon"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 264..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..545
FT /note="Missing (in isoform C)"
FT /evidence="ECO:0000303|PubMed:15858203,
FT ECO:0000303|PubMed:17969151, ECO:0000303|Ref.2"
FT /id="VSP_052646"
FT VAR_SEQ 546..565
FT /note="KVIGMTSILGPKPLTFFKKK -> MQASPDSARMECLWSNWKCQ (in
FT isoform C)"
FT /evidence="ECO:0000303|PubMed:15858203,
FT ECO:0000303|PubMed:17969151, ECO:0000303|Ref.2"
FT /id="VSP_052647"
FT CONFLICT 724
FT /note="D -> E (in Ref. 1; AAQ07265)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 752 AA; 83655 MW; E47ADBE983C460E9 CRC64;
MAANPEDFSG WLEGNVAAAR RHRGAEEEEG EAAEQGRTIK AQQAGHQPVA MEMTSTDSTN
IFHLHDRESK DHDDGLSYTY LSSDKHYISH PDSTYFTGIS KKETESLDKK EFSGAGPHSP
KEIPTFDSRG LFSSDSGIEM TPAEWSDVNR SLADPIEEEK LEACKYIDIR RSPDMKSQQV
VDAGFGANRS NTISQAAPTE QQTYDSVTMS WQKDHYNGNI SEYLPYMEEP REDFGLYHSP
TSKEPKSAPV TITFTGMETA LQTEYPGNQQ GKSNKGLRPS PDLVPTVTVS EPEEDSPESL
TPPSTDADGY AEPCGSEKQR EYGICEDELI SAIKAKEGTK RFSSETNDEK QSRSFHAEKQ
DFTVMSTEAT SASHYTKASS AESGDSEIEL VSEDQVGAEE AMQSAYMTFS HISGPPPSPA
SPSIQYSILR EEREAELDSE LIIESCDGSS ASEESPKRDP DSPMMKPMIM DIIEEENLSR
TESFEASDFE SCSLKEKKLN MENLAESASY LKGKFPAEIR ADMPSTKKEE FLPQKKSPEG
PAYQSKVIGM TSILGPKPLT FFKKKAIDLL YWRDVKQTGI VFGSILLMLF SLTLFSVVSV
IAYLALAALS ATISFRIYKS VLQAVQKTDE GHPFKSYLDI EISLSQEQIQ KYTGCFQLYT
NSIAKELRRL FLVQDLVDSL KFAVLMWLLT YVGALFNGLT LLIMAVVSMF SLPVVYDKYQ
AQIDQYLGLV RTNMNIIVTK IQAKIPGTKQ KE
