ID   RTN3A_XENLA             Reviewed;         214 AA.
AC   Q5J6M8; Q6IFY3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Reticulon-3-A;
DE   AltName: Full=RTN3.1;
GN   Name=rtn3-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=15765506; DOI=10.1002/dvdy.20327;
RA   Park E.C., Shim S., Han J.-K.;
RT   "Identification and expression of XRTN2 and XRTN3 during Xenopus
RT   development.";
RL   Dev. Dyn. 233:240-247(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=12832288; DOI=10.1096/fj.02-1166hyp;
RA   Oertle T., Klinger M., Stuermer C.A.O., Schwab M.E.;
RT   "A reticular rhapsody: phylogenic evolution and nomenclature of the
RT   RTN/Nogo gene family.";
RL   FASEB J. 17:1238-1247(2003).
CC   -!- FUNCTION: May be involved in membrane trafficking in the early
CC       secretory pathway. {ECO:0000250|UniProtKB:O95197}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:O95197}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:15765506}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O95197};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in the animal hemisphere at the four-cell
CC       stage. During gastrulation, expression becomes restricted to the
CC       prospective neuroectoderm. At the early tail bud stage, expressed in
CC       the head structure. At the tadpole stage, expressed in head and neural
CC       tissues including the otic vesicle and optic nerve.
CC       {ECO:0000269|PubMed:15765506}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC       {ECO:0000269|PubMed:15765506}.
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DR   EMBL; AY495964; AAS85780.1; -; mRNA.
DR   EMBL; BC073245; AAH73245.1; -; mRNA.
DR   EMBL; CD256485; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK004012; DAA02074.1; -; mRNA.
DR   RefSeq; NP_001085719.1; NM_001092250.1.
DR   AlphaFoldDB; Q5J6M8; -.
DR   SMR; Q5J6M8; -.
DR   MaxQB; Q5J6M8; -.
DR   DNASU; 444146; -.
DR   GeneID; 444146; -.
DR   KEGG; xla:444146; -.
DR   CTD; 444146; -.
DR   Xenbase; XB-GENE-975132; rtn3.L.
DR   OrthoDB; 1106300at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 444146; Expressed in brain and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:1902430; P:negative regulation of amyloid-beta formation; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003388; Reticulon.
DR   Pfam; PF02453; Reticulon; 1.
DR   PROSITE; PS50845; RETICULON; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..214
FT                   /note="Reticulon-3-A"
FT                   /id="PRO_0000280542"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          26..214
FT                   /note="Reticulon"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        152
FT                   /note="V -> I (in Ref. 1; AAS85780)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        169
FT                   /note="T -> A (in Ref. 1; AAS85780)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        172..174
FT                   /note="API -> TPL (in Ref. 1; AAS85780)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        178
FT                   /note="K -> R (in Ref. 1; AAS85780)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   214 AA;  23509 MW;  F86DFA5942357A42 CRC64;
     MAETSGPQSS HISSSSVGEK GSGCAVRDLL YWRDVKQSGM VFGGTMVLLL SLAAFSIISV
     ISYLVLSLLT VTISYRVYKS VLQAVQKTDE GHPFKPLLEK DITLSSDSFQ KALTASLAHV
     NHALKYIVRL FLVDDLVDSL KLALLMWLMT YVGAVFNGIT LLILGVLLTF TAPIVYEKYK
     VQIDHYVSLV HSQVKSITEK IQAKLPGALK KKSE