ID   RTN3B_XENLA             Reviewed;         214 AA.
AC   Q68EW1;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Reticulon-3-B;
DE   AltName: Full=RTN3.2;
GN   Name=rtn3-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15858203; DOI=10.1093/molbev/msi158;
RA   Diekmann H., Klinger M., Oertle T., Heinz D., Pogoda H.-M., Schwab M.E.,
RA   Stuermer C.A.O.;
RT   "Analysis of the reticulon gene family demonstrates the absence of the
RT   neurite growth inhibitor Nogo-A in fish.";
RL   Mol. Biol. Evol. 22:1635-1648(2005).
CC   -!- FUNCTION: May be involved in membrane trafficking in the early
CC       secretory pathway. {ECO:0000250|UniProtKB:O95197}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:O95197}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5J6M8}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O95197};
CC       Multi-pass membrane protein {ECO:0000255}.
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DR   EMBL; BC080089; AAH80089.1; -; mRNA.
DR   EMBL; CD303290; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK004057; DAA05161.1; -; mRNA.
DR   RefSeq; NP_001087545.1; NM_001094076.1.
DR   AlphaFoldDB; Q68EW1; -.
DR   SMR; Q68EW1; -.
DR   DNASU; 447369; -.
DR   GeneID; 447369; -.
DR   KEGG; xla:447369; -.
DR   CTD; 447369; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:1902430; P:negative regulation of amyloid-beta formation; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003388; Reticulon.
DR   Pfam; PF02453; Reticulon; 1.
DR   PROSITE; PS50845; RETICULON; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..214
FT                   /note="Reticulon-3-B"
FT                   /id="PRO_0000280543"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          26..214
FT                   /note="Reticulon"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..20
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  23360 MW;  068EFC13E1228595 CRC64;
     MAETSGPQSS HISSSSAGDK GSGCAVRDLL YWRDVKQSGM VFGGTMVLLL SLAAFSIISV
     ISYLVLSLLS VTISFRVYKS VLQAVQKTEE GHPFKPLLEK DIALSSDSFQ KGLSSSLAHV
     NHALKSIVRL FLVEDLVDSL KLALLMWLMT YIGAVFNGIT LLILGVLLAF TTPLVYEKYK
     VQIDHYVSLV HSQVKSITEK IQAKLPGALK KKSE