BCRA_BACLI
ID BCRA_BACLI Reviewed; 306 AA.
AC P42332;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Bacitracin transport ATP-binding protein BcrA;
GN Name=bcrA;
OS Bacillus licheniformis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=1402;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 9945A / NCIMB 11709;
RX PubMed=7476193; DOI=10.1111/j.1365-2958.1995.tb02322.x;
RA Podlesek Z., Comino A., Herzog-Velikonja B., Zgur-Bertok D., Komel R.,
RA Grabnar M.;
RT "Bacillus licheniformis bacitracin-resistance ABC transporter: relationship
RT to mammalian multidrug resistance.";
RL Mol. Microbiol. 16:969-976(1995).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC bacitracin that confer resistance to this antibiotic. Probably
CC responsible for energy coupling to the transport system (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; L20573; AAA99504.1; -; Unassigned_DNA.
DR PIR; S77627; S77627.
DR AlphaFoldDB; P42332; -.
DR SMR; P42332; -.
DR DrugBank; DB00626; Bacitracin.
DR TCDB; 3.A.1.131.1; the atp-binding cassette (abc) superfamily.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; ATP-binding; Nucleotide-binding; Transport.
FT CHAIN 1..306
FT /note="Bacitracin transport ATP-binding protein BcrA"
FT /id="PRO_0000091946"
FT DOMAIN 5..233
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 306 AA; 34641 MW; 6B33D1210B36A36A CRC64;
MSTIIKTTDL TKMYGSQKSV DHLNINVKQG DIYGFLGRNG AGKTTTIRML LGLIKPTSGQ
IEIFGENFFK NKKEILRRIG SIVEVPGFYA NLTARENLLI NAKIIGIHKK NAIDEVLEIV
GLQHETKKLV GKFSLGMKQR LGIARALLHY PELLILDEPT NGLDPIGIKE MRRLIHSLAK
ERNITIFISS HILSEIEQLV DHVGIIHEGK LLEEIPFDHL KKRNRKYLEF QLSDQNKAVV
LMEQHFDIHD YEVHQDGIIR VYSHLGQQGK LNKLFVENGI DVLKITMSED SLEDYFVKLI
GGGTIG