ID   RTN3_XENTR              Reviewed;         213 AA.
AC   Q28D16; Q6IFY2;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Reticulon-3;
GN   Name=rtn3; ORFNames=TGas074p07.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=12832288; DOI=10.1096/fj.02-1166hyp;
RA   Oertle T., Klinger M., Stuermer C.A.O., Schwab M.E.;
RT   "A reticular rhapsody: phylogenic evolution and nomenclature of the
RT   RTN/Nogo gene family.";
RL   FASEB J. 17:1238-1247(2003).
CC   -!- FUNCTION: May be involved in membrane trafficking in the early
CC       secretory pathway. {ECO:0000250|UniProtKB:O95197}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:O95197}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q5J6M8}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O95197};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA02075.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR855761; CAJ81633.1; -; mRNA.
DR   EMBL; CF242019; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK004013; DAA02075.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001016762.1; NM_001016762.2.
DR   AlphaFoldDB; Q28D16; -.
DR   SMR; Q28D16; -.
DR   STRING; 8364.ENSXETP00000005799; -.
DR   PaxDb; Q28D16; -.
DR   GeneID; 549516; -.
DR   KEGG; xtr:549516; -.
DR   CTD; 10313; -.
DR   Xenbase; XB-GENE-975126; rtn3.
DR   eggNOG; KOG1792; Eukaryota.
DR   InParanoid; Q28D16; -.
DR   OrthoDB; 423549at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:1902430; P:negative regulation of amyloid-beta formation; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003388; Reticulon.
DR   Pfam; PF02453; Reticulon; 1.
DR   PROSITE; PS50845; RETICULON; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..213
FT                   /note="Reticulon-3"
FT                   /id="PRO_0000280544"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          25..213
FT                   /note="Reticulon"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   213 AA;  23284 MW;  3F789DCCA4D737F0 CRC64;
     MADTSGPQSS HISSSAGEKG SGCAVQDLLY WRDVKQSGMV FGGTMVLLLS LAAFSIISVI
     SYLVLSLLAV TISYRVYKSV LQAVQKTDEG HPFKPLLEKD IALSSDAFQK ALSTSLAHVN
     HALKYIVRLF LVEDLVDSLK LALLMWLMTY VGAVFNGITL LILGVLLAFT APIVYEKYKV
     QIDHYVSLVH SHVKSITEKI QAKLPGALKK KSE