RTNLF_ARATH
ID RTNLF_ARATH Reviewed; 253 AA.
AC Q6DBN4; F4JFD4; Q9M312;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Reticulon-like protein B6;
DE Short=AtRTNLB6;
GN Name=RTNLB6; OrderedLocusNames=At3g61560; ORFNames=F2A19.160;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=15060130; DOI=10.1074/mcp.m400001-mcp200;
RA Marmagne A., Rouet M.-A., Ferro M., Rolland N., Alcon C., Joyard J.,
RA Garin J., Barbier-Brygoo H., Ephritikhine G.;
RT "Identification of new intrinsic proteins in Arabidopsis plasma membrane
RT proteome.";
RL Mol. Cell. Proteomics 3:675-691(2004).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17604024; DOI=10.1016/j.febslet.2007.06.032;
RA Nziengui H., Bouhidel K., Pillon D., Der C., Marty F., Schoefs B.;
RT "Reticulon-like proteins in Arabidopsis thaliana: structural organization
RT and ER localization.";
RL FEBS Lett. 581:3356-3362(2007).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9SH59}; Multi-pass membrane protein
CC {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:15060130}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q6DBN4-1; Sequence=Displayed;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB71086.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL132962; CAB71086.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE80222.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80223.2; -; Genomic_DNA.
DR EMBL; BT014988; AAT70439.1; -; mRNA.
DR EMBL; BT020345; AAV85700.1; -; mRNA.
DR PIR; T47948; T47948.
DR RefSeq; NP_001319815.1; NM_001340108.1. [Q6DBN4-1]
DR RefSeq; NP_191715.2; NM_116021.4. [Q6DBN4-1]
DR AlphaFoldDB; Q6DBN4; -.
DR SMR; Q6DBN4; -.
DR TCDB; 8.A.102.1.1; the reticulon (reticulon) family.
DR PRIDE; Q6DBN4; -.
DR ProteomicsDB; 226699; -. [Q6DBN4-1]
DR EnsemblPlants; AT3G61560.1; AT3G61560.1; AT3G61560. [Q6DBN4-1]
DR EnsemblPlants; AT3G61560.2; AT3G61560.2; AT3G61560. [Q6DBN4-1]
DR GeneID; 825329; -.
DR Gramene; AT3G61560.1; AT3G61560.1; AT3G61560. [Q6DBN4-1]
DR Gramene; AT3G61560.2; AT3G61560.2; AT3G61560. [Q6DBN4-1]
DR KEGG; ath:AT3G61560; -.
DR Araport; AT3G61560; -.
DR TAIR; locus:2082772; AT3G61560.
DR HOGENOM; CLU_066344_1_0_1; -.
DR InParanoid; Q6DBN4; -.
DR OMA; WKCQAME; -.
DR OrthoDB; 1106300at2759; -.
DR PhylomeDB; Q6DBN4; -.
DR PRO; PR:Q6DBN4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q6DBN4; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; IDA:TAIR.
DR GO; GO:0009617; P:response to bacterium; IEA:InterPro.
DR InterPro; IPR003388; Reticulon.
DR InterPro; IPR045064; Reticulon-like_plant.
DR PANTHER; PTHR10994; PTHR10994; 1.
DR Pfam; PF02453; Reticulon; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell membrane; Endoplasmic reticulum;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O82352"
FT CHAIN 2..253
FT /note="Reticulon-like protein B6"
FT /id="PRO_0000371287"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 68..253
FT /note="Reticulon"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT REGION 23..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O82352"
SQ SEQUENCE 253 AA; 28816 MW; 7ED2AEEA77D9EC1B CRC64;
MAEELEKSMH KEESLMEKIA DKIHDHDSSS SSDSEHEKPE SPSALKAKIY RLFGREKPVH
KVLGGGLPAD VFLWRDKKLS ASVLGVATAI WVLFELVEYH FLSLVCHILI FALAALFLLS
NAHAFMNKTP PKIPEIHIKE EHFLMIVSAL RNELNQAFVI LRSIALGRDL KKFLMVVFGL
WIISVVGNWF NFLTLVYICF VVLHTVPMLY EKHEDKVDPV AEKTLKELKK HYMVFDEKVL
SKLPVASLKA KLG
