RTNLH_ARATH
ID RTNLH_ARATH Reviewed; 247 AA.
AC Q9SS37; Q3EB99;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Reticulon-like protein B8;
DE Short=AtRTNLB8;
GN Name=RTNLB8; OrderedLocusNames=At3g10260; ORFNames=F14P13.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17604024; DOI=10.1016/j.febslet.2007.06.032;
RA Nziengui H., Bouhidel K., Pillon D., Der C., Marty F., Schoefs B.;
RT "Reticulon-like proteins in Arabidopsis thaliana: structural organization
RT and ER localization.";
RL FEBS Lett. 581:3356-3362(2007).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9SH59}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9SS37-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SS37-2; Sequence=VSP_037006;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
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DR EMBL; AC009400; AAF02816.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74879.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74880.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74881.1; -; Genomic_DNA.
DR EMBL; AY045830; AAK76504.1; -; mRNA.
DR EMBL; AY091368; AAM14307.1; -; mRNA.
DR EMBL; AY085435; AAM62662.1; -; mRNA.
DR RefSeq; NP_566371.1; NM_111861.3. [Q9SS37-1]
DR RefSeq; NP_850551.1; NM_180220.4. [Q9SS37-1]
DR RefSeq; NP_850552.1; NM_180221.3. [Q9SS37-2]
DR AlphaFoldDB; Q9SS37; -.
DR BioGRID; 5522; 27.
DR IntAct; Q9SS37; 26.
DR STRING; 3702.AT3G10260.3; -.
DR iPTMnet; Q9SS37; -.
DR PaxDb; Q9SS37; -.
DR PRIDE; Q9SS37; -.
DR ProteomicsDB; 226577; -. [Q9SS37-1]
DR EnsemblPlants; AT3G10260.1; AT3G10260.1; AT3G10260. [Q9SS37-1]
DR EnsemblPlants; AT3G10260.2; AT3G10260.2; AT3G10260. [Q9SS37-1]
DR EnsemblPlants; AT3G10260.3; AT3G10260.3; AT3G10260. [Q9SS37-2]
DR GeneID; 820188; -.
DR Gramene; AT3G10260.1; AT3G10260.1; AT3G10260. [Q9SS37-1]
DR Gramene; AT3G10260.2; AT3G10260.2; AT3G10260. [Q9SS37-1]
DR Gramene; AT3G10260.3; AT3G10260.3; AT3G10260. [Q9SS37-2]
DR KEGG; ath:AT3G10260; -.
DR Araport; AT3G10260; -.
DR TAIR; locus:2076284; AT3G10260.
DR eggNOG; KOG1792; Eukaryota.
DR HOGENOM; CLU_066344_1_2_1; -.
DR InParanoid; Q9SS37; -.
DR OMA; QFLWTNA; -.
DR OrthoDB; 1106300at2759; -.
DR PhylomeDB; Q9SS37; -.
DR PRO; PR:Q9SS37; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SS37; baseline and differential.
DR Genevisible; Q9SS37; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0009617; P:response to bacterium; IMP:TAIR.
DR InterPro; IPR003388; Reticulon.
DR InterPro; IPR045064; Reticulon-like_plant.
DR PANTHER; PTHR10994; PTHR10994; 1.
DR Pfam; PF02453; Reticulon; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..247
FT /note="Reticulon-like protein B8"
FT /id="PRO_0000371289"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 61..247
FT /note="Reticulon"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT VAR_SEQ 1
FT /note="M -> MKSTFICKLSNLRFRLCFRIM (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_037006"
SQ SEQUENCE 247 AA; 27913 MW; B49E9D6CCDE16376 CRC64;
MPDKNIVEDV IGDLVDNFTE TVQKNKHGSS FFEQEDSVSS RFNRLFDRQK PIHHVLGGGK
SADVLLWRNK KISASVLMGA TAIWVLFEWI NFHFLSLVCY ALLLGMIAQF VWSNASGFLN
RSQSRVPRLV LPKDFFAEVG VAVGKEVNRG LLFLQDLACK GNLKQFLMAV IGLWVAAMVG
SCCNFLTVLY IGFVGAHTMP VLYERYEDEV DGFMDSMIMK FHSHYKKLDT GFLSRIPSGK
FGLKKRE
