RTNLN_ARATH
ID RTNLN_ARATH Reviewed; 215 AA.
AC A2RVT6; F4HX72; Q9C9F8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Reticulon-like protein B14;
DE Short=AtRTNLB14;
GN Name=RTNLB14; OrderedLocusNames=At1g68230; ORFNames=T22E19.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Kim C.J., Bautista V.R., Chen H., De Los Reyes C., Wu S.Y., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17604024; DOI=10.1016/j.febslet.2007.06.032;
RA Nziengui H., Bouhidel K., Pillon D., Der C., Marty F., Schoefs B.;
RT "Reticulon-like proteins in Arabidopsis thaliana: structural organization
RT and ER localization.";
RL FEBS Lett. 581:3356-3362(2007).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q9SH59}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2RVT6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2RVT6-2; Sequence=VSP_037008, VSP_037009;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG52605.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC016447; AAG52605.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34767.2; -; Genomic_DNA.
DR EMBL; CP002684; AEE34768.2; -; Genomic_DNA.
DR EMBL; BT030077; ABN04815.1; -; mRNA.
DR PIR; G96705; G96705.
DR RefSeq; NP_001117568.1; NM_001124096.2. [A2RVT6-2]
DR RefSeq; NP_001319346.1; NM_001334358.1. [A2RVT6-1]
DR AlphaFoldDB; A2RVT6; -.
DR SMR; A2RVT6; -.
DR STRING; 3702.AT1G68230.2; -.
DR PaxDb; A2RVT6; -.
DR PRIDE; A2RVT6; -.
DR ProteomicsDB; 226615; -. [A2RVT6-1]
DR EnsemblPlants; AT1G68230.1; AT1G68230.1; AT1G68230. [A2RVT6-2]
DR EnsemblPlants; AT1G68230.2; AT1G68230.2; AT1G68230. [A2RVT6-1]
DR GeneID; 843152; -.
DR Gramene; AT1G68230.1; AT1G68230.1; AT1G68230. [A2RVT6-2]
DR Gramene; AT1G68230.2; AT1G68230.2; AT1G68230. [A2RVT6-1]
DR KEGG; ath:AT1G68230; -.
DR Araport; AT1G68230; -.
DR TAIR; locus:2199322; AT1G68230.
DR eggNOG; KOG1792; Eukaryota.
DR InParanoid; A2RVT6; -.
DR OMA; IMYERYE; -.
DR PhylomeDB; A2RVT6; -.
DR PRO; PR:A2RVT6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; A2RVT6; baseline and differential.
DR Genevisible; A2RVT6; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009617; P:response to bacterium; IEA:InterPro.
DR InterPro; IPR003388; Reticulon.
DR InterPro; IPR045064; Reticulon-like_plant.
DR PANTHER; PTHR10994; PTHR10994; 1.
DR Pfam; PF02453; Reticulon; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..215
FT /note="Reticulon-like protein B14"
FT /id="PRO_0000371295"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 31..211
FT /note="Reticulon"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT VAR_SEQ 160..162
FT /note="VFV -> GES (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_037008"
FT VAR_SEQ 163..215
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_037009"
SQ SEQUENCE 215 AA; 25259 MW; 5B69C7E74B1118AA CRC64;
MAVFGYEMDE HRASSSRRRR SLYHNLGGGR FADIMFWKNK KESGTILGVF TLIWFLFEVV
EYPFITFLCQ ILLLFIFIFL IWSYIGSSQL IQSKPPSIND LRISESNWRF LFNKINWFII
KLYDISSGKD FRLLFLAVVS LWILSVVGNY FSSLTLLYIV FVGLETIPML YEQYEEELTY
AASKSGRDMK KLLNKFNSKV INKIPKAQAK TRRTM
