RTNLQ_ARATH
ID RTNLQ_ARATH Reviewed; 431 AA.
AC Q6DR04; Q84X51; Q84X52; Q9SIV1;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Reticulon-like protein B17;
DE Short=AtRTNLB17;
GN Name=RTNLB17; OrderedLocusNames=At2g20590; ORFNames=F23N11.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Columbia;
RX PubMed=12481096; DOI=10.1104/pp.010207;
RA Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT of Arabidopsis.";
RL Plant Physiol. 130:2118-2128(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17604024; DOI=10.1016/j.febslet.2007.06.032;
RA Nziengui H., Bouhidel K., Pillon D., Der C., Marty F., Schoefs B.;
RT "Reticulon-like proteins in Arabidopsis thaliana: structural organization
RT and ER localization.";
RL FEBS Lett. 581:3356-3362(2007).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6DR04-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6DR04-2; Sequence=VSP_037012, VSP_037013;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD21707.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007048; AAD21707.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07036.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07037.1; -; Genomic_DNA.
DR EMBL; AY219045; AAO37135.1; -; mRNA.
DR EMBL; AY219046; AAO37136.1; -; mRNA.
DR EMBL; AY649311; AAT69228.1; -; mRNA.
DR PIR; B84591; B84591.
DR RefSeq; NP_179649.2; NM_127620.4. [Q6DR04-1]
DR RefSeq; NP_973488.1; NM_201759.3. [Q6DR04-2]
DR AlphaFoldDB; Q6DR04; -.
DR STRING; 3702.AT2G20590.1; -.
DR iPTMnet; Q6DR04; -.
DR PaxDb; Q6DR04; -.
DR PRIDE; Q6DR04; -.
DR EnsemblPlants; AT2G20590.1; AT2G20590.1; AT2G20590. [Q6DR04-1]
DR EnsemblPlants; AT2G20590.2; AT2G20590.2; AT2G20590. [Q6DR04-2]
DR GeneID; 816582; -.
DR Gramene; AT2G20590.1; AT2G20590.1; AT2G20590. [Q6DR04-1]
DR Gramene; AT2G20590.2; AT2G20590.2; AT2G20590. [Q6DR04-2]
DR KEGG; ath:AT2G20590; -.
DR Araport; AT2G20590; -.
DR TAIR; locus:2046021; AT2G20590.
DR eggNOG; ENOG502QU5C; Eukaryota.
DR InParanoid; Q6DR04; -.
DR OrthoDB; 1055759at2759; -.
DR PhylomeDB; Q6DR04; -.
DR PRO; PR:Q6DR04; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q6DR04; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR003388; Reticulon.
DR InterPro; IPR044647; RTNLB17/18/21.
DR PANTHER; PTHR46626; PTHR46626; 1.
DR Pfam; PF02453; Reticulon; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..431
FT /note="Reticulon-like protein B17"
FT /id="PRO_0000371298"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 168..355
FT /note="Reticulon"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 126..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..414
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 321..323
FT /note="VER -> GEE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12481096,
FT ECO:0000303|PubMed:16244158"
FT /id="VSP_037012"
FT VAR_SEQ 324..431
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12481096,
FT ECO:0000303|PubMed:16244158"
FT /id="VSP_037013"
FT CONFLICT 128
FT /note="R -> I (in Ref. 3; AAO37135/AAO37136)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 48397 MW; F681C3C4EB2C6D29 CRC64;
MESTPPYHRS NTKSASRLQD SSNPPNLSLD LVLSSPNTPN PSSPVPLRDI LLLPPSPLRK
SRTRLSDRLE MTSEDAMAVV RKRGKGKGGQ KSLLASPRNP RRSRRRSEAV EEKEANLVIE
EIVKLPPRKR KTNGRPKKDK QSSAPPLCSS SDLPNTCQSD LNLIGEIISD LVMWRDVAKS
TLWFGFGCLS FLSSCFAKGV NFSVFSAVSN LGLVLLCGSF LSNTLCQRKN EDTKRAFHVS
EDDVLRSARR VLPATNFFIS KTSELFSGEP SMTLKVTPFL LLGAEYGHLI TLWRLSAFGF
FLSFTIPKLY SCYTHQISQK VERVKTRIGE AWGVCSHKKI LAGSAVTAFW NLTSIRTRIF
AVFIILVIFR YRRQNLQLTP EEVEPVENEQ EEETLPQEEE TVPQEEETVP QEEEQTQPSE
ERALVVVVAE T
