ID   BCRB_BACLI              Reviewed;         208 AA.
AC   P42333;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Bacitracin transport permease protein BCRB;
GN   Name=bcrB;
OS   Bacillus licheniformis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1402;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 9945A / NCIMB 11709;
RX   PubMed=7476193; DOI=10.1111/j.1365-2958.1995.tb02322.x;
RA   Podlesek Z., Comino A., Herzog-Velikonja B., Zgur-Bertok D., Komel R.,
RA   Grabnar M.;
RT   "Bacillus licheniformis bacitracin-resistance ABC transporter: relationship
RT   to mammalian multidrug resistance.";
RL   Mol. Microbiol. 16:969-976(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 10716 / DSM 603 / NBRC 12199 / NCIMB 8874 / Tracy I;
RX   PubMed=9427658; DOI=10.1016/s1074-5521(97)90301-x;
RA   Konz D., Klens A., Schoergendorfer K., Marahiel M.A.;
RT   "The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716:
RT   molecular characterization of three multi-modular peptide synthetases.";
RL   Chem. Biol. 4:927-937(1997).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       bacitracin that confer resistance to this antibiotic; probably
CC       responsible for the translocation of the substrate across the membrane.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; L20573; AAA99505.1; -; Unassigned_DNA.
DR   EMBL; AF007865; AAD21214.1; -; Genomic_DNA.
DR   PIR; T31683; T31683.
DR   AlphaFoldDB; P42333; -.
DR   DrugBank; DB00626; Bacitracin.
DR   TCDB; 3.A.1.131.1; the atp-binding cassette (abc) superfamily.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..208
FT                   /note="Bacitracin transport permease protein BCRB"
FT                   /id="PRO_0000064894"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   208 AA;  23324 MW;  6E0EFDDF28AEDFD2 CRC64;
     MAKKAKYPDV PIRFSETFSD TNLYIVLLIG VPLYGVITSY LFNREYAEST LKNLLTIPVS
     RISLIVSKLV LLLIWIMMLT LIAWVLTLLF GLIGQFEGLS SAVLIEGFKQ FMIGGALLFF
     LVSPIIFVTL LFKNYVPTII FTIIISMVSI MVYGTEYSAL FPWSAVWVIA SGTFFPEYPP
     EYSFISVAAT TVLGLAATIV YFKKIDIH