RTNLR_ARATH
ID RTNLR_ARATH Reviewed; 457 AA.
AC Q8LDS3; O49452; Q0WU41;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Reticulon-like protein B18;
DE Short=AtRTNLB18;
GN Name=RTNLB18; OrderedLocusNames=At4g28430; ORFNames=F20O9.110;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17604024; DOI=10.1016/j.febslet.2007.06.032;
RA Nziengui H., Bouhidel K., Pillon D., Der C., Marty F., Schoefs B.;
RT "Reticulon-like proteins in Arabidopsis thaliana: structural organization
RT and ER localization.";
RL FEBS Lett. 581:3356-3362(2007).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA16882.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79645.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL021749; CAA16882.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161572; CAB79645.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85486.1; -; Genomic_DNA.
DR EMBL; AK227346; BAE99357.1; -; mRNA.
DR EMBL; AY085834; AAM63049.1; -; mRNA.
DR PIR; T04613; T04613.
DR RefSeq; NP_567809.1; NM_118985.3.
DR AlphaFoldDB; Q8LDS3; -.
DR SMR; Q8LDS3; -.
DR STRING; 3702.AT4G28430.1; -.
DR PaxDb; Q8LDS3; -.
DR PRIDE; Q8LDS3; -.
DR ProteomicsDB; 228071; -.
DR EnsemblPlants; AT4G28430.1; AT4G28430.1; AT4G28430.
DR GeneID; 828960; -.
DR Gramene; AT4G28430.1; AT4G28430.1; AT4G28430.
DR KEGG; ath:AT4G28430; -.
DR Araport; AT4G28430; -.
DR TAIR; locus:2121417; AT4G28430.
DR eggNOG; ENOG502QU5C; Eukaryota.
DR HOGENOM; CLU_036143_0_0_1; -.
DR InParanoid; Q8LDS3; -.
DR OMA; YSCYANQ; -.
DR OrthoDB; 1055759at2759; -.
DR PhylomeDB; Q8LDS3; -.
DR PRO; PR:Q8LDS3; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8LDS3; baseline and differential.
DR Genevisible; Q8LDS3; AT.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR003388; Reticulon.
DR InterPro; IPR044647; RTNLB17/18/21.
DR PANTHER; PTHR46626; PTHR46626; 1.
DR Pfam; PF02453; Reticulon; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..457
FT /note="Reticulon-like protein B18"
FT /id="PRO_0000371299"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 195..385
FT /note="Reticulon"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00170"
FT REGION 94..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 62
FT /note="P -> R (in Ref. 3; BAE99357)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="F -> L (in Ref. 4; AAM63049)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 457 AA; 51422 MW; 3B96A2BD7DB506E4 CRC64;
MDSTTTPPSL RSNTRSALRL ARNNKTLVKS HIPSLDLVLL SPKNNNGTPY PSPVSLSSPS
SPVTLREILL LSPSPLRKSR TRLSNRFDME AAEAAVTARR SKTKGGQNGL LASPSPRNFR
RSRLRSEAMV DTKENTEPIV VVTDEKKQNQ RKQKKLGRSK KEKHSSVPLL ASPSPSSDQP
QDVCQGDLER IRENISDLIM WRDVAKSTLW FGFGCICFLS TCFAAKGFNF SVFSAISYLG
LLFLGVSFLS NTLRQRVTEE ARRELKLSED DVLRIARRML PITNLAISKT SELFSGEPAM
TLKVAPFVLM GAEYGYLITL WRLCAFGFFL SFTIPKLYSC YASQLNQKVE CAQRRFVEAW
GVCTHKKFVA GSAVTAFWNL TSLKTRFIAV FIIVVVIRYR RQNLQLDSED EEEKKQQEKT
HPEQQKSPED KSTSPRSAEE EQALVLVAET KAPKKLY
