RTOR1_ARATH
ID RTOR1_ARATH Reviewed; 1344 AA.
AC Q93YQ1; Q9SR85;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 155.
DE RecName: Full=Regulatory-associated protein of TOR 1;
DE AltName: Full=Protein RAPTOR 1;
DE AltName: Full=Protein RAPTOR 1B;
DE Short=AtRaptor1b;
GN Name=RAPTOR1; Synonyms=RAPTOR1B; OrderedLocusNames=At3g08850;
GN ORFNames=T16O11.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=15607746; DOI=10.1016/j.bbrc.2004.11.117;
RA Deprost D., Truong H.N., Robaglia C., Meyer C.;
RT "An Arabidopsis homolog of RAPTOR/KOG1 is essential for early embryo
RT development.";
RL Biochem. Biophys. Res. Commun. 326:844-850(2005).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=15845148; DOI=10.1186/1741-7007-3-12;
RA Anderson G.H., Veit B., Hanson M.R.;
RT "The Arabidopsis AtRaptor genes are essential for post-embryonic plant
RT growth.";
RL BMC Biol. 3:12-12(2005).
RN [6]
RP INTERACTION WITH ML1.
RX PubMed=15720729; DOI=10.1186/1471-2229-5-2;
RA Anderson G.H., Hanson M.R.;
RT "The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue
RT of a major regulator of eukaryotic cell growth.";
RL BMC Plant Biol. 5:2-2(2005).
RN [7]
RP FUNCTION, AND INTERACTION WITH TOR AND ATPK1.
RX PubMed=16377759; DOI=10.1105/tpc.105.035931;
RA Mahfouz M.M., Kim S., Delauney A.J., Verma D.P.;
RT "Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the
RT activity of S6 kinase in response to osmotic stress signals.";
RL Plant Cell 18:477-490(2006).
RN [8]
RP INTERACTION WITH KIN10, PHOSPHORYLATION, SUBCELLULAR LOCATION, AND
RP DISRUPTION PHENOTYPE.
RX PubMed=27545962; DOI=10.1038/srep31697;
RA Nukarinen E., Naegele T., Pedrotti L., Wurzinger B., Mair A., Landgraf R.,
RA Boernke F., Hanson J., Teige M., Baena-Gonzalez E., Droege-Laser W.,
RA Weckwerth W.;
RT "Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog
RT SnRK1 as a metabolic master regulator under energy deprivation.";
RL Sci. Rep. 6:31697-31697(2016).
CC -!- FUNCTION: Probable component of the plant TOR kinase pathway that
CC recruits substrates for TOR. Modulates plant cell growth and regulates
CC the activity of ATPK1 kinase in response to osmotic stress.
CC {ECO:0000269|PubMed:16377759}.
CC -!- SUBUNIT: Interacts with TOR, ATPK1 and ML1. Interacts with KIN10
CC (PubMed:27545962). {ECO:0000269|PubMed:15720729,
CC ECO:0000269|PubMed:16377759, ECO:0000269|PubMed:27545962}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27545962}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, flowers and seeds.
CC {ECO:0000269|PubMed:15607746}.
CC -!- PTM: Phosphorylated by KIN10. {ECO:0000269|PubMed:27545962}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality when homozygous. Embryo
CC development arrested at very early stage (early pre-globular stage),
CC leading to aborted shrunken seeds. Constitutive autophagy
CC (PubMed:27545962). {ECO:0000269|PubMed:15607746,
CC ECO:0000269|PubMed:15845148, ECO:0000269|PubMed:27545962}.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF07837.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC010871; AAF07837.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74687.1; -; Genomic_DNA.
DR EMBL; AY059838; AAL24320.1; -; mRNA.
DR EMBL; BT008813; AAP68252.1; -; mRNA.
DR EMBL; AY769948; AAV84960.1; -; mRNA.
DR RefSeq; NP_566335.1; NM_111719.3.
DR PDB; 5WBI; X-ray; 3.00 A; A=1-1344.
DR PDB; 5WBJ; X-ray; 3.00 A; A=1-1344.
DR PDB; 5WBK; X-ray; 3.11 A; A=1-1344.
DR PDB; 5WBL; X-ray; 3.35 A; A=1-1344.
DR PDBsum; 5WBI; -.
DR PDBsum; 5WBJ; -.
DR PDBsum; 5WBK; -.
DR PDBsum; 5WBL; -.
DR AlphaFoldDB; Q93YQ1; -.
DR SMR; Q93YQ1; -.
DR BioGRID; 5366; 83.
DR IntAct; Q93YQ1; 82.
DR STRING; 3702.AT3G08850.1; -.
DR iPTMnet; Q93YQ1; -.
DR PaxDb; Q93YQ1; -.
DR PRIDE; Q93YQ1; -.
DR ProteomicsDB; 228031; -.
DR EnsemblPlants; AT3G08850.1; AT3G08850.1; AT3G08850.
DR GeneID; 820032; -.
DR Gramene; AT3G08850.1; AT3G08850.1; AT3G08850.
DR KEGG; ath:AT3G08850; -.
DR Araport; AT3G08850; -.
DR TAIR; locus:2097633; AT3G08850.
DR eggNOG; KOG1517; Eukaryota.
DR HOGENOM; CLU_001136_3_0_1; -.
DR InParanoid; Q93YQ1; -.
DR OMA; QWSCLCL; -.
DR OrthoDB; 97083at2759; -.
DR PhylomeDB; Q93YQ1; -.
DR PRO; PR:Q93YQ1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q93YQ1; baseline and differential.
DR Genevisible; Q93YQ1; AT.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0031931; C:TORC1 complex; IBA:GO_Central.
DR GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0010492; P:maintenance of shoot apical meristem identity; IMP:TAIR.
DR GO; GO:0010507; P:negative regulation of autophagy; IMP:UniProtKB.
DR GO; GO:0030307; P:positive regulation of cell growth; IBA:GO_Central.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12848; PTHR12848; 1.
DR Pfam; PF14538; Raptor_N; 1.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Developmental protein; Growth regulation;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1344
FT /note="Regulatory-associated protein of TOR 1"
FT /id="PRO_0000409332"
FT REPEAT 1025..1064
FT /note="WD 1"
FT REPEAT 1070..1111
FT /note="WD 2"
FT REPEAT 1125..1164
FT /note="WD 3"
FT REPEAT 1168..1208
FT /note="WD 4"
FT REPEAT 1214..1255
FT /note="WD 5"
FT REPEAT 1259..1298
FT /note="WD 6"
FT REPEAT 1307..1344
FT /note="WD 7"
FT REGION 28..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 62..66
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 76..78
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 85..88
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 106..115
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 122..124
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 139..142
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 143..160
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 163..173
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 176..189
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 191..204
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 212..216
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 218..220
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 222..227
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 228..234
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 237..247
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 249..256
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 263..268
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 271..279
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 295..301
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 303..313
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 314..316
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 318..321
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 323..328
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 339..358
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 361..369
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 372..389
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 390..392
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 396..399
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 410..429
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 440..453
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 457..460
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 465..471
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 475..477
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 478..490
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 493..502
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 505..510
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 511..513
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 517..519
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 520..531
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 537..543
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 544..546
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 547..555
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 561..575
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 579..587
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 590..597
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 610..624
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 628..636
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 639..643
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 644..647
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 648..650
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 652..664
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 686..700
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 706..722
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 724..734
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 832..844
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 849..861
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 959..961
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 966..970
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 971..973
FT /evidence="ECO:0007829|PDB:5WBI"
FT HELIX 986..1008
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1015..1017
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1030..1035
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1037..1046
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1050..1055
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 1056..1059
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1060..1067
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1075..1081
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1088..1093
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1096..1103
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1106..1108
FT /evidence="ECO:0007829|PDB:5WBJ"
FT STRAND 1111..1117
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1132..1136
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 1137..1140
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1141..1155
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 1156..1159
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1160..1166
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1169..1171
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1173..1178
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1180..1182
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1185..1190
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1195..1199
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1202..1204
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1206..1210
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1219..1221
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1226..1232
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1240..1246
FT /evidence="ECO:0007829|PDB:5WBI"
FT TURN 1247..1249
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1254..1258
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1264..1269
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1271..1289
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1294..1299
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1303..1305
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1314..1317
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1319..1327
FT /evidence="ECO:0007829|PDB:5WBI"
FT STRAND 1329..1337
FT /evidence="ECO:0007829|PDB:5WBI"
SQ SEQUENCE 1344 AA; 147963 MW; B09753A2629D80EB CRC64;
MALGDLMVSR FSQSSVSLVS NHRYDEDCVS SHDDGDSRRK DSEAKSSSSY GNGTTEGAAT
ATSMAYLPQT IVLCELRHDA SEASAPLGTS EIVLVPKWRL KERMKTGCVA LVLCLNITVD
PPDVIKISPC ARIEAWIDPF SMAPPKALET IGKNLSTQYE RWQPRARYKV QLDPTVDEVR
KLCLTCRKYA KTERVLFHYN GHGVPKPTAN GEIWVFNKSY TQYIPLPISE LDSWLKTPSI
YVFDCSAARM ILNAFAELHD WGSSGSSGSS RDCILLAACD VHETLPQSVE FPADVFTSCL
TTPIKMALKW FCRRSLLKEI IDESLIDRIP GRQNDRKTLL GELNWIFTAV TDTIAWNVLP
HELFQRLFRQ DLLVASLFRN FLLAERIMRS ANCNPISHPM LPPTHQHHMW DAWDMAAEIC
LSQLPQLVLD PSTEFQPSPF FTEQLTAFEV WLDHGSEHKK PPEQLPIVLQ VLLSQCHRFR
ALVLLGRFLD MGSWAVDLAL SVGIFPYVLK LLQTTTNELR QILVFIWTKI LALDKSCQID
LVKDGGHTYF IRFLDSSGAF PEQRAMAAFV LAVIVDGHRR GQEACLEANL IGVCLGHLEA
SRPSDPQPEP LFLQWLCLCL GKLWEDFMEA QIMGREANAF EKLAPLLSEP QPEVRAAAVF
ALGTLLDIGF DSNKSVVEDE FDDDEKIRAE DAIIKSLLDV VSDGSPLVRA EVAVALARFA
FGHKQHLKLA AASYWKPQSS SLLTSLPSIA KFHDPGSATI VSLHMSPLTR ASTDSQPVAR
ESRISSSPLG SSGLMQGSPL SDDSSLHSDS GMMHDSVSNG AVHQPRLLDN AVYSQCVRAM
FALAKDPSPR IASLGRRVLS IIGIEQVVAK PSKPTGRPGE AATTSHTPLA GLARSSSWFD
MHAGNLPLSF RTPPVSPPRT NYLSGLRRVC SLEFRPHLLG SPDSGLADPL LGASGSERSL
LPLSTIYGWS CGHFSKPLLG GADASQEIAA KREEKEKFAL EHIAKCQHSS ISKLNNNPIA
NWDTRFETGT KTALLHPFSP IVVAADENER IRVWNYEEAT LLNGFDNHDF PDKGISKLCL
INELDDSLLL VASCDGSVRI WKNYATKGKQ KLVTGFSSIQ GHKPGARDLN AVVDWQQQSG
YLYASGETST VTLWDLEKEQ LVRSVPSESE CGVTALSASQ VHGGQLAAGF ADGSLRLYDV
RSPEPLVCAT RPHQKVERVV GLSFQPGLDP AKVVSASQAG DIQFLDLRTT RDTYLTIDAH
RGSLTALAVH RHAPIIASGS AKQLIKVFSL QGEQLGIIRY YPSFMAQKIG SVSCLTFHPY
QVLLAAGAAD SFVSIYTHDN SQAR
