RTOR1_ORYSJ
ID RTOR1_ORYSJ Reviewed; 1218 AA.
AC C7J8E5; A0A0P0XYC8;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Regulatory-associated protein of TOR 1 {ECO:0000305};
DE AltName: Full=Protein RAPTOR 1 {ECO:0000303|PubMed:25956502};
DE Short=OsRAPTOR1 {ECO:0000303|PubMed:25956502};
GN Name=RAPTOR1;
GN OrderedLocusNames=Os11g0109933 {ECO:0000312|EMBL:BAT12359.1},
GN LOC_Os11g01872 {ECO:0000305};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25956502; DOI=10.1007/s00438-015-1056-0;
RA Maegawa K., Takii R., Ushimaru T., Kozaki A.;
RT "Evolutionary conservation of TORC1 components, TOR, Raptor, and LST8,
RT between rice and yeast.";
RL Mol. Genet. Genomics 290:2019-2030(2015).
CC -!- FUNCTION: Component of TORC1 complex, which is an essential cell growth
CC regulator that controls plant development. Acts by recruiting
CC substrates for TOR. Acts by activating transcription, protein synthesis
CC and ribosome biogenesis, and inhibiting mRNA degradation and autophagy.
CC {ECO:0000305|PubMed:25956502}.
CC -!- SUBUNIT: The target of rapamycin complex 1 (TORC1) is composed of at
CC least RAPTOR, LST8 and TOR. {ECO:0000305|PubMed:25956502}.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAH95036.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAT12359.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AP008217; BAH95036.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014967; BAT12359.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; C7J8E5; -.
DR SMR; C7J8E5; -.
DR STRING; 39947.C7J8E5; -.
DR PaxDb; C7J8E5; -.
DR PRIDE; C7J8E5; -.
DR EnsemblPlants; Os11t0109933-01; Os11t0109933-01; Os11g0109933.
DR Gramene; Os11t0109933-01; Os11t0109933-01; Os11g0109933.
DR eggNOG; KOG1517; Eukaryota.
DR HOGENOM; CLU_001136_3_0_1; -.
DR InParanoid; C7J8E5; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR Genevisible; C7J8E5; OS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031931; C:TORC1 complex; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0030307; P:positive regulation of cell growth; IBA:GO_Central.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12848; PTHR12848; 1.
DR Pfam; PF14538; Raptor_N; 1.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Growth regulation; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..1218
FT /note="Regulatory-associated protein of TOR 1"
FT /id="PRO_0000409335"
FT REPEAT 899..938
FT /note="WD 1"
FT REPEAT 945..985
FT /note="WD 2"
FT REPEAT 997..1036
FT /note="WD 3"
FT REPEAT 1040..1080
FT /note="WD 4"
FT REPEAT 1087..1128
FT /note="WD 5"
FT REPEAT 1132..1171
FT /note="WD 6"
FT REPEAT 1180..1218
FT /note="WD 7"
FT REGION 640..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1218 AA; 134815 MW; E8CA00872B149CC1 CRC64;
MAPPKALETI GKTLHSQYER WQPKARYKLQ LDPTLEEVKK LCNTCRKFAR TERVLFHYNG
HGVPKPTANG EIWVFNKSYT QYIPLPITDL DSWLKTPSIY VFDCSAAGMI VKAFLERLDW
SSSSSASSSK DCILLAACEA HQTLPQSAEF PADVFTACLT TPIKMALHWF CNRSLLRDSM
EHNLIDQIPG RQNDRKTLLG ELNWIFTAIT DTIAWNVLPH DLFQRLFRQD LLVASLFRNF
LLAERIMRSA NCSPISYPLL PPTHQHHMWD AWDMAAEICL SKLPQLIADP NAEFQPSPFF
TEQLTAFEVW LDHGSEDKKP PEQLPIVLQV LLSQSHRFRA LVLLGRFLDM GPWAVDLALS
VGIFPYVLKL LQTSAMELRQ ILVFIWTKIL SLDKSCQVDL VKDGGHAYFI RFLDSLDAYP
EQRAMAAFVL AVIVDGHRVG QEACANAGLI YVCLRHLQPE NPNDAQTEPL LLQWLCLCLG
KLWEDFPEAQ LLGLQSNAPE IVICLLSEPQ PEVRASAVFA LGNLVDIGSP SLNGADDDSD
DDEKVRAEIN VVRSLLQISS DGSPLVRSEV AVALTRFAMG HNKHIKSVAA EYWKPQTNSL
LKSLPSLANI NSSNVYSPSS LIQGSSGLAS HIGPVLRVGS DNSATARDGR ISTSSPIATN
SIMHGSPQSD DSSQHSDSGI LLRENASNGG LNYSRSRPID NGIYSQFIAT MCNVAKDPYP
RIASIGKRAL SLIGVEQVSM RNSRLSNGGA HPGETSVPPS SNFGMARSSS WFDMNSGNFS
MAFRTPPVSP PQHDYLTGLR RVCSMEFRPH VLNSPDGLAD PLLSSSAAPS NMGLDILPQS
LIYRWSCGHF SRPLLTGSDD NEEANARREE RERIAMDCIA KCQRSSCKMT SQIASWDTRF
ELGTKASLLL PFSPIVVAAD ENEQIRVWNY DDALPVNTFE NHKLSDRGLS KLLLINELDD
SLLLVGSSDG NVRIWRNYTQ KGGQKLVTAF SSVQGYRSAG RSIVFDWQQQ SGYLYASGDM
SSILVWDLDK EQLVNTIQST ADSGISALSA SQVRCGQFAA GFLDASVRIF DVRTPDRLVY
TARPHAPRSE KVVGIGFQPG FDPYKIVSAS QAGDIQFLDV RRASEPYLTI EAHRGSLMAL
AVHRHAPVIA SGSAKQMIKV FSLEGEQLTI IRYQPSFMGQ RIGSVNCLSF HRYKSLLAAG
AGDNALVSIY AEDNYQVQ
