RTOR2_ARATH
ID RTOR2_ARATH Reviewed; 1336 AA.
AC Q9LZW9;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 25-MAY-2022, entry version 154.
DE RecName: Full=Regulatory-associated protein of TOR 2;
DE AltName: Full=Protein RAPTOR 1A;
DE Short=AtRaptor1a;
DE AltName: Full=Protein RAPTOR 2;
GN Name=RAPTOR2; Synonyms=RAPTOR1A; OrderedLocusNames=At5g01770;
GN ORFNames=T20L15.40;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=15607746; DOI=10.1016/j.bbrc.2004.11.117;
RA Deprost D., Truong H.N., Robaglia C., Meyer C.;
RT "An Arabidopsis homolog of RAPTOR/KOG1 is essential for early embryo
RT development.";
RL Biochem. Biophys. Res. Commun. 326:844-850(2005).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=15845148; DOI=10.1186/1741-7007-3-12;
RA Anderson G.H., Veit B., Hanson M.R.;
RT "The Arabidopsis AtRaptor genes are essential for post-embryonic plant
RT growth.";
RL BMC Biol. 3:12-12(2005).
CC -!- FUNCTION: Probable component of the plant TOR kinase pathway.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in roots, leaves, flowers
CC and seeds. {ECO:0000269|PubMed:15607746}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC condition. {ECO:0000269|PubMed:15607746, ECO:0000269|PubMed:15845148}.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family. {ECO:0000305}.
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DR EMBL; AL162351; CAB82747.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90389.1; -; Genomic_DNA.
DR PIR; T48198; T48198.
DR RefSeq; NP_195797.3; NM_120255.3.
DR AlphaFoldDB; Q9LZW9; -.
DR SMR; Q9LZW9; -.
DR BioGRID; 16957; 2.
DR IntAct; Q9LZW9; 2.
DR STRING; 3702.AT5G01770.1; -.
DR iPTMnet; Q9LZW9; -.
DR PaxDb; Q9LZW9; -.
DR PRIDE; Q9LZW9; -.
DR ProteomicsDB; 226579; -.
DR EnsemblPlants; AT5G01770.1; AT5G01770.1; AT5G01770.
DR GeneID; 831681; -.
DR Gramene; AT5G01770.1; AT5G01770.1; AT5G01770.
DR KEGG; ath:AT5G01770; -.
DR Araport; AT5G01770; -.
DR TAIR; locus:2180997; AT5G01770.
DR eggNOG; KOG1517; Eukaryota.
DR HOGENOM; CLU_001136_3_0_1; -.
DR InParanoid; Q9LZW9; -.
DR OrthoDB; 97083at2759; -.
DR PRO; PR:Q9LZW9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LZW9; baseline and differential.
DR Genevisible; Q9LZW9; AT.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031931; C:TORC1 complex; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0010492; P:maintenance of shoot apical meristem identity; IGI:TAIR.
DR GO; GO:0030307; P:positive regulation of cell growth; IBA:GO_Central.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12848; PTHR12848; 1.
DR Pfam; PF14538; Raptor_N; 1.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1336
FT /note="Regulatory-associated protein of TOR 2"
FT /id="PRO_0000409333"
FT REPEAT 1008..1047
FT /note="WD 1"
FT REPEAT 1053..1102
FT /note="WD 2"
FT REPEAT 1116..1155
FT /note="WD 3"
FT REPEAT 1159..1199
FT /note="WD 4"
FT REPEAT 1205..1246
FT /note="WD 5"
FT REPEAT 1250..1289
FT /note="WD 6"
FT REPEAT 1298..1336
FT /note="WD 7"
FT REGION 746..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1336 AA; 147640 MW; 7E6A5C25A4476D17 CRC64;
MALGDLMVSR LSQSSVTVVT NHLYDDDDNC ASSAHDDSRV SIIASPRVAS SSYENLSAAT
SMAYLPQTLV LCDLRHDDAS DIVQPPRWRL KERMKTGCVA LVMCLHITVD PPDVIKISPC
ARLECWIDPF SMFPPRRALE AIGQNLSIQY ERWLARARYK VELDPTKDDV RKLCLSCRKY
AKTERVLFHY NGHGVPKPTP NGEIWVYNKN FTQYIPLPVS ELDSWLKTPT IYVFDCSAAR
VILNAFAEGE SSGPPKDCIL LAACDVHETL PQSVEFPADV FTSCLTTPIN IALKWFCRRS
LLKEFIDESL IDRIPGRQND RKTLLGELNW IFTAVTDTIA WNVLPRELFQ RLFRQDLLVA
SLFRNFLLAE RIMRSGNCTP ISHPMLPPTH QHHMWDAWDM AAEICLSQLP QFFLDPNTEF
QPSSFFTEQL TAFEVWLDHG SEHKKPPEQL PIVLQVLLSQ CHRYRALVLL GRFLDMGPWA
VDLALSVGIY PCVVKLLQTT TIELRQILVF IWTKILALDK SCQVDLVKDR GHIYFIRFLD
SSDAFPEQRA MAAFILAVIV DGYKRGQESC LEANLIAVCL GHLEATQLCD PPPEPLFLQW
LCLCLGKLWE DYLEAQIMGR EANASENLIA GHTNLLQVRA AAVFALGTLL DVGFDSGKGV
CDEEFDDDEN IVEDIIIKSL LDVVSDGSPL VRTEVAVALA RFAFGHKQHL KSVADSYWKP
QNSLRTSLPS MAKFHDSGTS IVASSDMGSL TRASPDSQPV AREGRISSSL QEPFSGLMQG
SPLADDSSLH SDVGIIHDGV SNGVVHQPRP LDNAIYSQSV LAMFTLAKDP SPRIASLGRR
VLSVIGIEQI VAKPSKSNGR PGEAASASHT PLAGLVRSSS WFDMHTGHLP LTFRTPPVSP
PQTSYLTGLR RVCSLELRPH LLGSPDSGLA DPILGVSGSE RSLLPQSTIY NWSCGHFSKP
LLGGADANEE IAAQREEKKK FSLEHIAKCQ HSSISGLSNI PIANWDTKFE TGTKTALLHP
FSPIVVAADE NERIRVWNYE EATLLNGFDN NDFPDKGISN LCLVNELDDS LLLVASCNVP
TLSRASFAIR IWKDYATKGR QKLVTGFSSI QGQKPGASGL NAVVDWQQQS GYLYVSGESL
SIMVWDLDKE QLVKSMPFES GCSVTALSAS QVHGSQLAAG FADGSVRLYD VRTPDFLVCA
TRPHQRVEKV VGLSFQPGLD PAKIVSASQA GDIQFLDLRR PKETYLTIDA HRGSLTALGV
HRHAPIIASG SAKQLIKVFS LKGEQLGIIK YHTSFMGQQI GPVSCLAFHP YQMLLAAGAA
GSFVSLYTHH NTQLPR
