RTOR2_ORYSJ
ID RTOR2_ORYSJ Reviewed; 1359 AA.
AC Q0IQN5; A0A0P0Y607; H2KWV1; Q6RUS5;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Regulatory-associated protein of TOR 2 {ECO:0000305};
DE AltName: Full=Protein RAPTOR 2 {ECO:0000303|PubMed:25956502};
DE Short=OsRAPTOR2 {ECO:0000303|PubMed:25956502};
GN Name=RAPTOR2;
GN OrderedLocusNames=Os12g0110000 {ECO:0000312|EMBL:BAT15547.1},
GN LOC_Os12g01922 {ECO:0000312|EMBL:ABG21850.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 118-1359.
RA Lu X., Gong H., Bai S.;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND SUBUNIT.
RX PubMed=25956502; DOI=10.1007/s00438-015-1056-0;
RA Maegawa K., Takii R., Ushimaru T., Kozaki A.;
RT "Evolutionary conservation of TORC1 components, TOR, Raptor, and LST8,
RT between rice and yeast.";
RL Mol. Genet. Genomics 290:2019-2030(2015).
CC -!- FUNCTION: Component of TORC1 complex, which is an essential cell growth
CC regulator that controls plant development. Acts by recruiting
CC substrates for TOR. Acts by activating transcription, protein synthesis
CC and ribosome biogenesis, and inhibiting mRNA degradation and autophagy.
CC {ECO:0000305|PubMed:25956502}.
CC -!- SUBUNIT: The target of rapamycin complex 1 (TORC1) is composed of at
CC least RAPTOR, LST8 and TOR. {ECO:0000305|PubMed:25956502}.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF28980.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAT15547.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DP000011; ABG21850.1; -; Genomic_DNA.
DR EMBL; AP008218; BAF28980.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014968; BAT15547.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY491431; AAR82959.1; -; mRNA.
DR RefSeq; XP_015620077.1; XM_015764591.1.
DR AlphaFoldDB; Q0IQN5; -.
DR SMR; Q0IQN5; -.
DR STRING; 4530.OS12T0110000-00; -.
DR iPTMnet; Q0IQN5; -.
DR PaxDb; Q0IQN5; -.
DR PRIDE; Q0IQN5; -.
DR EnsemblPlants; Os12t0110000-01; Os12t0110000-01; Os12g0110000.
DR GeneID; 4351289; -.
DR Gramene; Os12t0110000-01; Os12t0110000-01; Os12g0110000.
DR KEGG; osa:4351289; -.
DR eggNOG; KOG1517; Eukaryota.
DR HOGENOM; CLU_001136_3_0_1; -.
DR InParanoid; Q0IQN5; -.
DR OrthoDB; 97083at2759; -.
DR Proteomes; UP000000763; Chromosome 12.
DR Proteomes; UP000059680; Chromosome 12.
DR Genevisible; Q0IQN5; OS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031931; C:TORC1 complex; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0030307; P:positive regulation of cell growth; IBA:GO_Central.
DR GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0010506; P:regulation of autophagy; IBA:GO_Central.
DR GO; GO:0031929; P:TOR signaling; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12848; PTHR12848; 1.
DR Pfam; PF14538; Raptor_N; 1.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Growth regulation; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..1359
FT /note="Regulatory-associated protein of TOR 2"
FT /id="PRO_0000409334"
FT REPEAT 1041..1080
FT /note="WD 1"
FT REPEAT 1087..1127
FT /note="WD 2"
FT REPEAT 1139..1178
FT /note="WD 3"
FT REPEAT 1181..1221
FT /note="WD 4"
FT REPEAT 1228..1269
FT /note="WD 5"
FT REPEAT 1273..1312
FT /note="WD 6"
FT REPEAT 1321..1359
FT /note="WD 7"
FT REGION 17..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 163
FT /note="W -> C (in Ref. 5; AAR82959)"
FT /evidence="ECO:0000305"
FT CONFLICT 366
FT /note="Q -> L (in Ref. 5; AAR82959)"
FT /evidence="ECO:0000305"
FT CONFLICT 479
FT /note="R -> G (in Ref. 5; AAR82959)"
FT /evidence="ECO:0000305"
FT CONFLICT 977
FT /note="Y -> D (in Ref. 5; AAR82959)"
FT /evidence="ECO:0000305"
FT CONFLICT 1142
FT /note="G -> V (in Ref. 5; AAR82959)"
FT /evidence="ECO:0000305"
FT CONFLICT 1273
FT /note="A -> T (in Ref. 5; AAR82959)"
FT /evidence="ECO:0000305"
FT CONFLICT 1283
FT /note="V -> A (in Ref. 5; AAR82959)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1359 AA; 149808 MW; CD28077B7CF0AA08 CRC64;
MALGDLMASR LVHSSSSSAA PSAALPNHHT NHLVDDHLPV ENGPDPRRDV PDEEPPPPPP
PQVALLPQVV VLCEQRHEGF DEAAAAAAGP STSGPVSKWR PKDRMKTGCV ALVLCLNISV
DPPDVIKISP CARKECWIDP FSMAPPKALE TIGKTLHSQY ERWQPKARYK LQLDPTLEEV
KKLCNTCRKF ARTERVLFHY NGHGVPKPTA NGEIWVFNKS YTQYIPLPIT DLDSWLKTPS
IYVFDCSAAG MIVKAFLERL DWSSSSSASS SKDCILLAAC EAHQTLPQSA EFPADVFTAC
LTTPIKMALH WFCNRSLLRD SMEHNLIDQI PGRQNDRKTL LGELNWIFTA ITDTIAWNVL
PHDLFQRLFR QDLLVASLFR NFLLAERIMR SANCSPISYP LLPPTHQHHM WDAWDMAAEI
CLSKLPQLIA DPNAEFQPSP FFTEQLTAFE VWLDHGSEDK KPPEQLPIVL QVLLSQSHRF
RALVLLGRFL DMGPWAVDLA LSVGIFPYVL KLLQTSAMEL RQILVFIWTK ILSLDKSCQV
DLVKDGGHAY FIRFLDSLDA YPEQRAMAAF VLAVIVDGHR IGQEACANAG LIDVCLRHLQ
PENPNDAQTE PLLLQWLCLC LGKLWEDFPE AQLLGLQSNA PEIVICLLSE PQPEVRASAV
FALGNLVDIG SPSLNGADDD SDDDEKVRAE INVVRSLLQI SSDGSPLVRS EVAVALTRFA
MGHNKHIKSV AAEYWKPQTN SLLKSLPSLA NINSSNVYSP SSLIQGSSGL ASHIGPVLRV
GSDNSATARD GRISTSSPIA TNSIMHGSPQ SDDSSQHSDS GILLRENASN GGLNYSRSRP
IDNGIYSQFI ATMCNVAKDP YPRIASIGKR ALSLIGVEQV SMRNSRLSNG GAHPGETSVP
PSSNFGMARS SSWFDMNSGN FSVAFRTPPV SPPQHDYLTG LRRVCSMEFR PHVLNSPDGL
ADPLLSSSAA PSNMGLYILP QSLIYRWSCG HFSRPLLTGS DDNEEANARR EERERIAMDC
IAKCQRSSCK MTSQIASWDT RFELGTKASL LLPFSPIVVA ADENEQIRVW NYDDALPVNT
FENHKLSDRG LSKLLLINEL DDSLLLVGSS DGNVRIWRNY TQKGGQKLVT AFSSVQGYRS
AGRSIVFDWQ QQSGYLYASG DMSSILVWDL DKEQVNTIQS TADSGISALS ASQVRCGQFA
AGFLDASVRI FDVRTPDRLV YTARPHAPRS EKVVGIGFQP GFDPYKIVSA SQAGDIQFLD
VRRASEPYLT IEAHRGSLTA LAVHRHAPVI ASGSAKQMIK VFSLEGEQLT IIRYQPSFMG
QRIGSVNCLS FHRYKSLLAA GAGDNALVSI YAEDNYQVR
