RTP1_HUMAN
ID RTP1_HUMAN Reviewed; 263 AA.
AC P59025;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Receptor-transporting protein 1;
DE AltName: Full=3CxxC-type zinc finger protein 1;
GN Name=RTP1; Synonyms=Z3CXXC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 37-263.
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=16720576; DOI=10.1074/jbc.m513637200;
RA Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., Meyerhof W.;
RT "Members of RTP and REEP gene families influence functional bitter taste
RT receptor expression.";
RL J. Biol. Chem. 281:20650-20659(2006).
RN [4]
RP VARIANT [LARGE SCALE ANALYSIS] SER-124.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Specifically promotes functional cell surface expression of
CC olfactory receptors, but not of other GPCRs. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with olfactory receptors. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III
CC membrane protein {ECO:0000250}. Note=Effective cell surface expression
CC depends upon interaction with olfactory receptors. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:16720576}.
CC -!- SIMILARITY: Belongs to the TMEM7 family. {ECO:0000305}.
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DR EMBL; BC034744; AAH34744.4; -; mRNA.
DR EMBL; BC065202; AAH65202.2; -; mRNA.
DR EMBL; AY562235; AAT70680.1; -; mRNA.
DR CCDS; CCDS3287.2; -.
DR RefSeq; NP_714919.2; NM_153708.2.
DR AlphaFoldDB; P59025; -.
DR BioGRID; 126305; 1.
DR STRING; 9606.ENSP00000311712; -.
DR iPTMnet; P59025; -.
DR PhosphoSitePlus; P59025; -.
DR BioMuta; RTP1; -.
DR DMDM; 61252249; -.
DR MassIVE; P59025; -.
DR PaxDb; P59025; -.
DR PeptideAtlas; P59025; -.
DR PRIDE; P59025; -.
DR Antibodypedia; 46840; 94 antibodies from 19 providers.
DR DNASU; 132112; -.
DR Ensembl; ENST00000312295.5; ENSP00000311712.4; ENSG00000175077.6.
DR GeneID; 132112; -.
DR KEGG; hsa:132112; -.
DR MANE-Select; ENST00000312295.5; ENSP00000311712.4; NM_153708.3; NP_714919.2.
DR UCSC; uc003frg.3; human.
DR CTD; 132112; -.
DR DisGeNET; 132112; -.
DR GeneCards; RTP1; -.
DR HGNC; HGNC:28580; RTP1.
DR HPA; ENSG00000175077; Tissue enhanced (brain).
DR MIM; 609137; gene.
DR neXtProt; NX_P59025; -.
DR OpenTargets; ENSG00000175077; -.
DR PharmGKB; PA143485604; -.
DR VEuPathDB; HostDB:ENSG00000175077; -.
DR eggNOG; ENOG502S1UZ; Eukaryota.
DR GeneTree; ENSGT00940000161858; -.
DR HOGENOM; CLU_092465_0_0_1; -.
DR InParanoid; P59025; -.
DR OMA; WDFIIDP; -.
DR OrthoDB; 1504302at2759; -.
DR PhylomeDB; P59025; -.
DR TreeFam; TF333246; -.
DR PathwayCommons; P59025; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; P59025; -.
DR BioGRID-ORCS; 132112; 11 hits in 1060 CRISPR screens.
DR GenomeRNAi; 132112; -.
DR Pharos; P59025; Tbio.
DR PRO; PR:P59025; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P59025; protein.
DR Bgee; ENSG00000175077; Expressed in oocyte and 55 other tissues.
DR Genevisible; P59025; HS.
DR GO; GO:0009986; C:cell surface; IDA:HGNC-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031849; F:olfactory receptor binding; IMP:HGNC-UCL.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IDA:HGNC-UCL.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR026096; R-trans_p.
DR InterPro; IPR026692; RTP1.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR14402; PTHR14402; 1.
DR PANTHER; PTHR14402:SF19; PTHR14402:SF19; 1.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..263
FT /note="Receptor-transporting protein 1"
FT /id="PRO_0000181988"
FT TOPO_DOM 1..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT VARIANT 124
FT /note="R -> S (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036122"
FT VARIANT 212
FT /note="A -> G (in dbSNP:rs35053281)"
FT /id="VAR_053729"
FT VARIANT 229
FT /note="Q -> E (in dbSNP:rs6764714)"
FT /id="VAR_053730"
SQ SEQUENCE 263 AA; 30913 MW; 80B2F845DDC81F2B CRC64;
MRIFRPWRLR CPALHLPSLS VFSLRWKLPS LTTDETMCKS VTTDEWKKVF YEKMEEAKPA
DSWDLIIDPN LKHNVLSPGW KQYLELHASG RFHCSWCWHT WQSPYVVILF HMFLDRAQRA
GSVRMRVFKQ LCYECGTARL DESSMLEENI EGLVDNLITS LREQCYGERG GQYRIHVASR
QDNRRHRGEF CEACQEGIVH WKPSEKLLEE EATTYTFSRA PSPTKSQDQT GSGWNFCSIP
WCLFWATVLL LIIYLQFSFR SSV
