RTP1_MOUSE
ID RTP1_MOUSE Reviewed; 263 AA.
AC Q8C8C1;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Receptor-transporting protein 1;
GN Name=Rtp1; Synonyms=Gm604;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND INTERACTION WITH OLFACTORY RECEPTORS.
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Specifically promotes functional cell surface expression of
CC olfactory receptors, but not of other GPCRs.
CC {ECO:0000269|PubMed:15550249}.
CC -!- SUBUNIT: Interacts with olfactory receptors.
CC {ECO:0000269|PubMed:15550249}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15550249};
CC Single-pass type III membrane protein {ECO:0000269|PubMed:15550249}.
CC Note=Effective cell surface expression depends upon interaction with
CC olfactory receptors.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in olfactory and
CC vomeronasal organs, in mature olfactory sensory neurons.
CC {ECO:0000269|PubMed:15550249}.
CC -!- SIMILARITY: Belongs to the TMEM7 family. {ECO:0000305}.
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DR EMBL; AY562225; AAT70670.1; -; mRNA.
DR EMBL; AK047543; BAC33083.1; -; mRNA.
DR CCDS; CCDS28078.1; -.
DR RefSeq; NP_001004151.1; NM_001004151.2.
DR AlphaFoldDB; Q8C8C1; -.
DR CORUM; Q8C8C1; -.
DR STRING; 10090.ENSMUSP00000043416; -.
DR PhosphoSitePlus; Q8C8C1; -.
DR PaxDb; Q8C8C1; -.
DR PRIDE; Q8C8C1; -.
DR ProteomicsDB; 260742; -.
DR Antibodypedia; 46840; 94 antibodies from 19 providers.
DR DNASU; 239766; -.
DR Ensembl; ENSMUST00000038730; ENSMUSP00000043416; ENSMUSG00000033383.
DR GeneID; 239766; -.
DR KEGG; mmu:239766; -.
DR UCSC; uc007ytq.1; mouse.
DR CTD; 132112; -.
DR MGI; MGI:2685450; Rtp1.
DR VEuPathDB; HostDB:ENSMUSG00000033383; -.
DR eggNOG; ENOG502S1UZ; Eukaryota.
DR GeneTree; ENSGT00940000161858; -.
DR HOGENOM; CLU_092465_0_0_1; -.
DR InParanoid; Q8C8C1; -.
DR OMA; WDFIIDP; -.
DR OrthoDB; 1504302at2759; -.
DR PhylomeDB; Q8C8C1; -.
DR TreeFam; TF333246; -.
DR BioGRID-ORCS; 239766; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8C8C1; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8C8C1; protein.
DR Bgee; ENSMUSG00000033383; Expressed in primary visual cortex and 8 other tissues.
DR ExpressionAtlas; Q8C8C1; baseline and differential.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0031849; F:olfactory receptor binding; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; ISO:MGI.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR026096; R-trans_p.
DR InterPro; IPR026692; RTP1.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR14402; PTHR14402; 1.
DR PANTHER; PTHR14402:SF19; PTHR14402:SF19; 1.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..263
FT /note="Receptor-transporting protein 1"
FT /id="PRO_0000181990"
FT TOPO_DOM 1..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..263
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 263 AA; 30732 MW; BA12E392354F33D7 CRC64;
MRIFRPWRLR CPALHLPSFP TFSIKCSLPP LPTDEDMCKS VTTGEWKKVF YEKMEEVKPA
DSWDFIIDPN LKHNVLAPGW KQYLELHASG RFHCSWCWHT WQSPHVVILF HMYLDKAQRA
GSVRMRVFKQ LCYECGTARL DESSMLEENI ESLVDNLITS LREQCYGERG GHYRIHVASR
QDNRRHRGEF CEACQEGIVH WKPSEKLLEE EATTYTFSRA PSPTKPQAET GSGCNFCSIP
WCLFWATVLM LIIYLQFSFR TSV
