RTP1_SCHPO
ID RTP1_SCHPO Reviewed; 747 AA.
AC O42977;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=RNA polymerase II assembly factor rtp1 {ECO:0000250|UniProtKB:Q12751};
GN Name=rtp1 {ECO:0000250|UniProtKB:Q12751};
GN ORFNames=SPBC20F10.08c {ECO:0000312|PomBase:SPBC20F10.08c};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for the cytoplasmic assembly and the nuclear import
CC of RNA polymerase II. {ECO:0000250|UniProtKB:Q12751}.
CC -!- SUBUNIT: Interacts with RNA polymerase II subunits. Interacts with
CC nuclear pore complex subunits. {ECO:0000250|UniProtKB:Q12751}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the Tango6 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA16848.1; -; Genomic_DNA.
DR PIR; T39879; T39879.
DR RefSeq; NP_596372.1; NM_001022293.2.
DR AlphaFoldDB; O42977; -.
DR STRING; 4896.SPBC20F10.08c.1; -.
DR MaxQB; O42977; -.
DR PaxDb; O42977; -.
DR EnsemblFungi; SPBC20F10.08c.1; SPBC20F10.08c.1:pep; SPBC20F10.08c.
DR GeneID; 2540770; -.
DR KEGG; spo:SPBC20F10.08c; -.
DR PomBase; SPBC20F10.08c; rtp1.
DR VEuPathDB; FungiDB:SPBC20F10.08c; -.
DR eggNOG; KOG4653; Eukaryota.
DR HOGENOM; CLU_363756_0_0_1; -.
DR InParanoid; O42977; -.
DR OMA; YVHLNVI; -.
DR PRO; PR:O42977; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006606; P:protein import into nucleus; ISO:PomBase.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019451; Rtp1_C1.
DR InterPro; IPR039600; TANGO6/Rtp1.
DR PANTHER; PTHR20959; PTHR20959; 1.
DR Pfam; PF10363; RTP1_C1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..747
FT /note="RNA polymerase II assembly factor rtp1"
FT /id="PRO_0000372364"
FT REPEAT 37..75
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 103..141
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 320..358
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 381..418
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 459..485
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 486..523
FT /note="HEAT 6"
FT /evidence="ECO:0000255"
FT REPEAT 557..594
FT /note="HEAT 7"
FT /evidence="ECO:0000255"
SQ SEQUENCE 747 AA; 84837 MW; E63462342CC86DBA CRC64;
MDANQKLLDF AKLLNQKNDS RPVIEKLKDN ISGDLLNYFL NLLEEISKLD TDQPLSVTSL
RCLQLFVHLT FLLGVYTQLP KEMLSQAKIK ALPIYTPKKN LVQIYNILLP LLLTPSLLQG
PLNLHYADLL LLHLYLLNCH EQGSLIEEPR PLFLDPSWKE KVTSIMSPQM VDPSKMISSC
LSLLQPNVDN WLQDKLKHYL TTCLCRETGV QGFLKVYMQA QPNSIERARQ AAHLISSVPK
DISPQKYFSC ILPQVWSLFS TQPRLASQLI IAVTNTHCDI VTSFLLKKLQ ILEAPKVIDL
SPFENALDVL QVLVYIQNDD IIRICESCVP SLLHLQENTT LRSKVQDILL RIISVCGTKS
LLRNLTNAKH LRIFCERLTK SQLAMFLPNL LEIWVQQPPD KRLELLELVQ YALSNVDSDE
IPSNVMLSVC TNLINEVASQ NKYSSTEISQ ITTNREVEEE NEEILLVLLN IISSVIGRNA
ELDLENPISS LLPALEQLSN YSNREISDLA KDVYKTLIQS KDDYSLALSY TQSDLVPVRG
QGVYMLRKLI EKKDDRINPV RVLHVLINLL RDENSYVHLN VISAVVSLCD KYDDSLIRLL
KEYTNTNKFT VDETLLIGQA IYQTMERQGE LVAKFYGQIE QTCLSMLNNE NTDIKISSLN
IARLLCQMTS SDAFIESAKN ILILEMGSDK QFLRRAAVQL LDSCKHLPDS VITTLSYVGS
HDKDDFIKES CLNILANQAD AAKYYLQ
