RTP1_YEAST
ID RTP1_YEAST Reviewed; 981 AA.
AC Q12751; D6W009;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=RNA polymerase II assembly factor RTP1 {ECO:0000305|PubMed:23438601};
DE AltName: Full=Required for nuclear transport of RNA pol II protein 1 {ECO:0000303|PubMed:23438601};
DE AltName: Full=Transport and Golgi organization protein 6 homolog {ECO:0000250|UniProtKB:Q9VJ29};
GN Name=RTP1 {ECO:0000303|PubMed:23438601};
GN OrderedLocusNames=YMR185W {ECO:0000312|SGD:S000004797}; ORFNames=YM8010.15;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 650-981.
RX PubMed=7645348; DOI=10.1002/yea.320110607;
RA Erkine A.M., Szent-Gyorgyi C., Simmons S.F., Gross D.S.;
RT "The upstream sequences of the HSP82 and HSC82 genes of Saccharomyces
RT cerevisiae: regulatory elements and nucleosome positioning motifs.";
RL Yeast 11:573-580(1995).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 976-981.
RX PubMed=2674684; DOI=10.1128/mcb.9.9.3919-3930.1989;
RA Borkovich K.A., Farrelly F.W., Finkelstein D.B., Taulien J., Lindquist S.;
RT "hsp82 is an essential protein that is required in higher concentrations
RT for growth of cells at higher temperatures.";
RL Mol. Cell. Biol. 9:3919-3930(1989).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH NUP100; NUP116;
RP RPB2;RPB3 AND THE R2TP COMPLEX.
RX PubMed=23438601; DOI=10.1128/mcb.01449-12;
RA Gomez-Navarro N., Peiro-Chova L., Rodriguez-Navarro S., Polaina J.,
RA Estruch F.;
RT "Rtp1p is a karyopherin-like protein required for RNA polymerase II
RT biogenesis.";
RL Mol. Cell. Biol. 33:1756-1767(2013).
CC -!- FUNCTION: Required for the cytoplasmic assembly and the nuclear import
CC of RNA polymerase II. May facilitate the starting interaction between
CC RNA polymerase II subunits RPB2 and RPB3 and the subsequent interaction
CC of the resulting complex with subunit RPB1. May also participate in the
CC transport of RNA polymerase II through the nuclear pore complex.
CC {ECO:0000269|PubMed:23438601}.
CC -!- SUBUNIT: Interacts with RNA polymerase II subunits RPB2 and RPB3.
CC Interacts with the R2TP complex. Interacts with the nuclear pore
CC complex subunits NUP100 and NUP116. {ECO:0000269|PubMed:23438601}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23438601}.
CC -!- SIMILARITY: Belongs to the Tango6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA87904.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; Z49808; CAA89918.1; -; Genomic_DNA.
DR EMBL; U20349; AAA87904.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006946; DAA10083.1; -; Genomic_DNA.
DR PIR; S55132; S55132.
DR RefSeq; NP_013910.1; NM_001182691.1.
DR AlphaFoldDB; Q12751; -.
DR BioGRID; 35363; 20.
DR IntAct; Q12751; 1.
DR STRING; 4932.YMR185W; -.
DR MaxQB; Q12751; -.
DR PaxDb; Q12751; -.
DR PRIDE; Q12751; -.
DR EnsemblFungi; YMR185W_mRNA; YMR185W; YMR185W.
DR GeneID; 855223; -.
DR KEGG; sce:YMR185W; -.
DR SGD; S000004797; RTP1.
DR VEuPathDB; FungiDB:YMR185W; -.
DR eggNOG; KOG4653; Eukaryota.
DR GeneTree; ENSGT00390000010938; -.
DR HOGENOM; CLU_006300_1_0_1; -.
DR InParanoid; Q12751; -.
DR OMA; KRAYGAP; -.
DR BioCyc; YEAST:G3O-32873-MON; -.
DR PRO; PR:Q12751; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; Q12751; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0006606; P:protein import into nucleus; IMP:SGD.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019451; Rtp1_C1.
DR InterPro; IPR019414; Rtp1_C2.
DR InterPro; IPR039600; TANGO6/Rtp1.
DR PANTHER; PTHR20959; PTHR20959; 1.
DR Pfam; PF10363; RTP1_C1; 1.
DR Pfam; PF10304; RTP1_C2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Repeat.
FT CHAIN 1..981
FT /note="RNA polymerase II assembly factor RTP1"
FT /id="PRO_0000203322"
FT REPEAT 64..101
FT /note="HEAT 1"
FT /evidence="ECO:0000255"
FT REPEAT 161..199
FT /note="HEAT 2"
FT /evidence="ECO:0000255"
FT REPEAT 226..261
FT /note="HEAT 3"
FT /evidence="ECO:0000255"
FT REPEAT 366..403
FT /note="HEAT 4"
FT /evidence="ECO:0000255"
FT REPEAT 609..646
FT /note="HEAT 5"
FT /evidence="ECO:0000255"
FT REPEAT 655..692
FT /note="HEAT 6"
FT /evidence="ECO:0000255"
FT REPEAT 765..799
FT /note="HEAT 7"
FT /evidence="ECO:0000255"
FT REPEAT 800..836
FT /note="HEAT 8"
FT /evidence="ECO:0000255"
FT REPEAT 945..980
FT /note="HEAT 9"
FT /evidence="ECO:0000255"
FT REGION 630..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..650
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 113249 MW; 13F29F65C6D4E53B CRC64;
MNEDKEQKIN IHDILNTRPK LTKKTALDVF FEDLDDNVIT PINEYVLDSG SSSSSSIYQA
LKCSNNNEFV AVLLQKFQNL HIHVLEQQRR LIESKSDLLP ISLHDMKYVD ELINLLIIHG
IDANLSPTMK IPFDSKRINT FKKGQKSAEY ETPRWHTINN DTLSQVITVF YNVLTSERSS
DYLREIISKG SAYANILLGL IVLHLQLPNR YSSQMITNLE DTQETYTLFG VYTLLVETIQ
DEKVREPILS KLTTLTLRRP ENGLISLIDF VLGVRDAEDI DIEKFNRIYQ ILMSKPKTMT
NLQYLTELFK QIYDGLTFVN RPILVTCLNG LILKFYLRNK RIVNDFLFKK VRSIIFNSPL
TDHTAKELND VINVLISLSK NSSSDLLNDL VTSCPDEDGT TPGQFFLYVW IYALFLKKNQ
KLDPLEINKL SISDNKSTDS IHFPEQSSSK YYEVVLSLLK SLIVITENFQ YLNVLSLNLL
NFEHEKWKYL IDLDTQLPYI SVKNTDMAEL FFEKGSKNSQ ISEFLQDMDL SIELFMEFLV
LLNDEEQSKT LFLDILKRWV HHTKKSEKRS SDNHSGMPSV TDNALILMDL KLLECMNNRF
KTKIVNKPKD VLIVIDQLID VVQEKDETIQ EVEADSDDEV EEGEETEELD PNENSSYKII
LQLLSTVLSE SSSSILLQNS YILKSISRKL QSFNTNASEI DALLASIDNI LINGHTTERN
DNIEIEMDEE RLDKAITSLH DPLVPIKSYG LTELRHLAEK KSPVISLEKV LQIHLDYLKN
MDPFIYLNVI KGLTTLCELE PETILPLLAE FYANKKKKNR LDDVLKVGEV FINYIQRQNE
LFQGKLAYLI IDTCLSIVRP NDSKPLDNRW RMSSMSILGM CLQINARGVS DRIRDMLDCV
FGILQLEQPQ NHLKDKDDSF LMRRSAVHLI HDLLYSTGFD LLPFEYNYDK LKTLLSYVRD
QDEDYMVCEQ IDKLLTVLDS L
