RTP2_HUMAN
ID RTP2_HUMAN Reviewed; 225 AA.
AC Q5QGT7; Q6NVH4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Receptor-transporting protein 2;
DE AltName: Full=3CxxC-type zinc finger protein 2;
GN Name=RTP2; Synonyms=Z3CXXC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT "RTP family members induce functional expression of mammalian odorant
RT receptors.";
RL Cell 119:679-691(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-82.
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=16720576; DOI=10.1074/jbc.m513637200;
RA Behrens M., Bartelt J., Reichling C., Winnig M., Kuhn C., Meyerhof W.;
RT "Members of RTP and REEP gene families influence functional bitter taste
RT receptor expression.";
RL J. Biol. Chem. 281:20650-20659(2006).
CC -!- FUNCTION: Specifically promotes functional cell surface expression of
CC olfactory receptors, but not of other GPCRs. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with olfactory receptors. {ECO:0000250}.
CC -!- INTERACTION:
CC Q5QGT7; Q9BV23: ABHD6; NbExp=3; IntAct=EBI-10244780, EBI-3916106;
CC Q5QGT7; P16157-17: ANK1; NbExp=3; IntAct=EBI-10244780, EBI-941819;
CC Q5QGT7; Q68DC2: ANKS6; NbExp=3; IntAct=EBI-10244780, EBI-7054139;
CC Q5QGT7; P41181: AQP2; NbExp=3; IntAct=EBI-10244780, EBI-12701138;
CC Q5QGT7; Q13520: AQP6; NbExp=3; IntAct=EBI-10244780, EBI-13059134;
CC Q5QGT7; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-10244780, EBI-11343438;
CC Q5QGT7; P04233-2: CD74; NbExp=3; IntAct=EBI-10244780, EBI-12222807;
CC Q5QGT7; P11912: CD79A; NbExp=3; IntAct=EBI-10244780, EBI-7797864;
CC Q5QGT7; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-10244780, EBI-1045797;
CC Q5QGT7; O95471: CLDN7; NbExp=3; IntAct=EBI-10244780, EBI-740744;
CC Q5QGT7; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-10244780, EBI-18013275;
CC Q5QGT7; Q5JRM2: CXorf66; NbExp=3; IntAct=EBI-10244780, EBI-12823659;
CC Q5QGT7; Q15125: EBP; NbExp=3; IntAct=EBI-10244780, EBI-3915253;
CC Q5QGT7; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-10244780, EBI-18535450;
CC Q5QGT7; Q9H5J4: ELOVL6; NbExp=3; IntAct=EBI-10244780, EBI-12821617;
CC Q5QGT7; A1L3X0: ELOVL7; NbExp=3; IntAct=EBI-10244780, EBI-10285373;
CC Q5QGT7; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10244780, EBI-781551;
CC Q5QGT7; P22794: EVI2A; NbExp=3; IntAct=EBI-10244780, EBI-2870359;
CC Q5QGT7; P34910-2: EVI2B; NbExp=3; IntAct=EBI-10244780, EBI-17640610;
CC Q5QGT7; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-10244780, EBI-18636064;
CC Q5QGT7; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-10244780, EBI-18304435;
CC Q5QGT7; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-10244780, EBI-18938272;
CC Q5QGT7; Q969F0: FATE1; NbExp=3; IntAct=EBI-10244780, EBI-743099;
CC Q5QGT7; O15552: FFAR2; NbExp=3; IntAct=EBI-10244780, EBI-2833872;
CC Q5QGT7; O00258: GET1; NbExp=3; IntAct=EBI-10244780, EBI-18908258;
CC Q5QGT7; P08034: GJB1; NbExp=3; IntAct=EBI-10244780, EBI-17565645;
CC Q5QGT7; O95377: GJB5; NbExp=3; IntAct=EBI-10244780, EBI-3909454;
CC Q5QGT7; Q96P66: GPR101; NbExp=3; IntAct=EBI-10244780, EBI-17935713;
CC Q5QGT7; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-10244780, EBI-13345167;
CC Q5QGT7; O15529: GPR42; NbExp=3; IntAct=EBI-10244780, EBI-18076404;
CC Q5QGT7; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10244780, EBI-11721746;
CC Q5QGT7; P31937: HIBADH; NbExp=3; IntAct=EBI-10244780, EBI-11427100;
CC Q5QGT7; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-10244780, EBI-1052304;
CC Q5QGT7; P38484: IFNGR2; NbExp=3; IntAct=EBI-10244780, EBI-3905457;
CC Q5QGT7; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-10244780, EBI-10266796;
CC Q5QGT7; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-10244780, EBI-749265;
CC Q5QGT7; P48051: KCNJ6; NbExp=3; IntAct=EBI-10244780, EBI-12017638;
CC Q5QGT7; P43628: KIR2DL3; NbExp=3; IntAct=EBI-10244780, EBI-8632435;
CC Q5QGT7; Q16363-3: LAMA4; NbExp=3; IntAct=EBI-10244780, EBI-17719490;
CC Q5QGT7; Q13571: LAPTM5; NbExp=3; IntAct=EBI-10244780, EBI-2865663;
CC Q5QGT7; O95214: LEPROTL1; NbExp=3; IntAct=EBI-10244780, EBI-750776;
CC Q5QGT7; Q9H400: LIME1; NbExp=3; IntAct=EBI-10244780, EBI-2830566;
CC Q5QGT7; Q6N075: MFSD5; NbExp=3; IntAct=EBI-10244780, EBI-3920969;
CC Q5QGT7; O95182: NDUFA7; NbExp=3; IntAct=EBI-10244780, EBI-721471;
CC Q5QGT7; O14524-2: NEMP1; NbExp=3; IntAct=EBI-10244780, EBI-10969203;
CC Q5QGT7; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-10244780, EBI-716063;
CC Q5QGT7; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-10244780, EBI-7545592;
CC Q5QGT7; Q8NC24: RELL2; NbExp=3; IntAct=EBI-10244780, EBI-10269209;
CC Q5QGT7; Q6P5S7: RNASEK; NbExp=3; IntAct=EBI-10244780, EBI-18397230;
CC Q5QGT7; Q9BY50: SEC11C; NbExp=3; IntAct=EBI-10244780, EBI-2855401;
CC Q5QGT7; O95470: SGPL1; NbExp=3; IntAct=EBI-10244780, EBI-1046170;
CC Q5QGT7; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-10244780, EBI-18159983;
CC Q5QGT7; Q13336-2: SLC14A1; NbExp=3; IntAct=EBI-10244780, EBI-19141793;
CC Q5QGT7; O95436-2: SLC34A2; NbExp=3; IntAct=EBI-10244780, EBI-12811757;
CC Q5QGT7; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-10244780, EBI-2823239;
CC Q5QGT7; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-10244780, EBI-17280858;
CC Q5QGT7; P27105: STOM; NbExp=3; IntAct=EBI-10244780, EBI-1211440;
CC Q5QGT7; Q16623: STX1A; NbExp=3; IntAct=EBI-10244780, EBI-712466;
CC Q5QGT7; P32856-2: STX2; NbExp=3; IntAct=EBI-10244780, EBI-11956649;
CC Q5QGT7; Q9NYW4: TAS2R5; NbExp=3; IntAct=EBI-10244780, EBI-17933167;
CC Q5QGT7; Q8WY91: THAP4; NbExp=3; IntAct=EBI-10244780, EBI-726691;
CC Q5QGT7; Q0VDI3: TMEM267; NbExp=3; IntAct=EBI-10244780, EBI-17555467;
CC Q5QGT7; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-10244780, EBI-11722971;
CC Q5QGT7; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-10244780, EBI-726044;
CC Q5QGT7; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-10244780, EBI-18178701;
CC Q5QGT7; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-10244780, EBI-2548832;
CC Q5QGT7; Q6UXU6: TMEM92; NbExp=3; IntAct=EBI-10244780, EBI-10975829;
CC Q5QGT7; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-10244780, EBI-11724433;
CC Q5QGT7; Q9Y320: TMX2; NbExp=3; IntAct=EBI-10244780, EBI-6447886;
CC Q5QGT7; Q9BZF9: UACA; NbExp=3; IntAct=EBI-10244780, EBI-350510;
CC Q5QGT7; Q3ZAQ7: VMA21; NbExp=3; IntAct=EBI-10244780, EBI-1055364;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III
CC membrane protein {ECO:0000250}. Note=Effective cell surface expression
CC depends upon interaction with olfactory receptors. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in circumvallate papillae and testis.
CC {ECO:0000269|PubMed:16720576}.
CC -!- SIMILARITY: Belongs to the TMEM7 family. {ECO:0000305}.
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DR EMBL; AY562236; AAT70681.1; -; mRNA.
DR EMBL; BC068081; AAH68081.1; -; mRNA.
DR CCDS; CCDS33911.1; -.
DR RefSeq; NP_001004312.2; NM_001004312.2.
DR RefSeq; XP_016861790.1; XM_017006301.1.
DR RefSeq; XP_016861791.1; XM_017006302.1.
DR AlphaFoldDB; Q5QGT7; -.
DR BioGRID; 131331; 84.
DR IntAct; Q5QGT7; 72.
DR STRING; 9606.ENSP00000350976; -.
DR iPTMnet; Q5QGT7; -.
DR PhosphoSitePlus; Q5QGT7; -.
DR BioMuta; RTP2; -.
DR DMDM; 61216423; -.
DR jPOST; Q5QGT7; -.
DR MassIVE; Q5QGT7; -.
DR PaxDb; Q5QGT7; -.
DR PeptideAtlas; Q5QGT7; -.
DR PRIDE; Q5QGT7; -.
DR Antibodypedia; 19329; 94 antibodies from 17 providers.
DR DNASU; 344892; -.
DR Ensembl; ENST00000358241.1; ENSP00000350976.1; ENSG00000198471.1.
DR GeneID; 344892; -.
DR KEGG; hsa:344892; -.
DR MANE-Select; ENST00000358241.1; ENSP00000350976.1; NM_001004312.2; NP_001004312.2.
DR UCSC; uc003fro.1; human.
DR CTD; 344892; -.
DR DisGeNET; 344892; -.
DR GeneCards; RTP2; -.
DR HGNC; HGNC:32486; RTP2.
DR HPA; ENSG00000198471; Group enriched (skeletal muscle, testis).
DR MIM; 609138; gene.
DR neXtProt; NX_Q5QGT7; -.
DR OpenTargets; ENSG00000198471; -.
DR PharmGKB; PA143485605; -.
DR VEuPathDB; HostDB:ENSG00000198471; -.
DR eggNOG; ENOG502S1UZ; Eukaryota.
DR GeneTree; ENSGT00940000162172; -.
DR HOGENOM; CLU_092465_0_0_1; -.
DR InParanoid; Q5QGT7; -.
DR OMA; DSWELIM; -.
DR OrthoDB; 1504302at2759; -.
DR PhylomeDB; Q5QGT7; -.
DR TreeFam; TF333246; -.
DR PathwayCommons; Q5QGT7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q5QGT7; -.
DR BioGRID-ORCS; 344892; 8 hits in 1060 CRISPR screens.
DR GenomeRNAi; 344892; -.
DR Pharos; Q5QGT7; Tbio.
DR PRO; PR:Q5QGT7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q5QGT7; protein.
DR Bgee; ENSG00000198471; Expressed in gastrocnemius and 5 other tissues.
DR GO; GO:0009986; C:cell surface; IDA:HGNC-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031849; F:olfactory receptor binding; IMP:HGNC-UCL.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IDA:HGNC-UCL.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR026096; R-trans_p.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR14402; PTHR14402; 1.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..225
FT /note="Receptor-transporting protein 2"
FT /id="PRO_0000181991"
FT TOPO_DOM 1..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..225
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT VARIANT 82
FT /note="Q -> R (in dbSNP:rs11707167)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_021488"
SQ SEQUENCE 225 AA; 26068 MW; 62F8ADA80DC90A73 CRC64;
MCTSLTTCEW KKVFYEKMEV AKPADSWELI IDPNLKPSEL APGWKQYLEQ HASGRFHCSW
CWHTWQSAHV VILFHMFLDR AQRAGSVRMR VFKQLCYECG TARLDESSML EENIEGLVDN
LITSLREQCY EEDGGQYRIH VASRPDSGPH RAEFCEACQE GIVHWKPSEK LLEEEVTTYT
SEASKPRAQA GSGYNFLSLR WCLFWASLCL LVVYLQFSFL SPAFF
